H2B1_CHICK - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: H2B1_CHICK
• UniProt AC: P0C1H3
• Protein Name: Histone H2B 1/2/3/4/6
• Gene Name: H2B-I
• Organism: Gallus gallus (Chicken).
• Sequence Length: 126
• Subcellular Localization: Nucleus. Chromosome.
• Protein Description: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; Has broad-spectrum antibacterial activity. May be important in the antimicrobial defenses of chick reproductive system during follicle development in the ovary and egg formation in the oviduct..
• Protein Sequence: MPEPAKSAPAPKKGSKKAVTKTQKKGDKKRKKSRKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Acetylation	--MPEPAKSAPAPKK --CCCCCCCCCCCCC	58.84	12865423
13	Acetylation	KSAPAPKKGSKKAVT CCCCCCCCCCCCCCH	68.32	12865423
15	Phosphorylation	APAPKKGSKKAVTKT CCCCCCCCCCCCHHH	39.60	12757711
16	Acetylation	PAPKKGSKKAVTKTQ CCCCCCCCCCCHHHH	54.11	12865423
21	Acetylation	GSKKAVTKTQKKGDK CCCCCCHHHHHCCCH	42.22	12865423
121	Ubiquitination	EGTKAVTKYTSSK-- HHHHHHHHHCCCC--	39.67	2713375

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of H2B1_CHICK !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of H2B1_CHICK !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of H2B1_CHICK !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Acetylation of histone H2B mirrors that of H4 and H3 at the chickenbeta-globin locus but not at housekeeping genes.";
Myers F.A., Chong W., Evans D.R., Thorne A.W., Crane-Robinson C.;
J. Biol. Chem. 278:36315-36322(2003).
Cited for: ACETYLATION AT LYS-6; LYS-13; LYS-16 AND LYS-21.
PubMed: 12865423

Phosphorylation

"Apoptotic phosphorylation of histone H2B is mediated by mammaliansterile twenty kinase.";
Cheung W.L., Ajiro K., Samejima K., Kloc M., Cheung P., Mizzen C.A.,Beeser A., Etkin L.D., Chernoff J., Earnshaw W.C., Allis C.D.;
Cell 113:507-517(2003).
Cited for: PHOSPHORYLATION AT SER-15.
PubMed: 12757711