dbPTM

H2AZL_XENLA - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	H2AZL_XENLA
UniProt AC	P70094
Protein Name	Histone H2A.Z-like
Gene Name	h2a.zl1
Organism	Xenopus laevis (African clawed frog).
Sequence Length	128
Subcellular Localization	Nucleus. Chromosome.
Protein Description	Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be required at gastrulation for correct mesoderm formation..
Protein Sequence	MAGGKAGKDTGKAKATSITRSSRAGLQFPVGRIHRLLKNRTTSHGRVGGTAAVYTAAILEYLTAEVLELAGNASKDLKVKRISPRHLQLAIRGDEELDALIKATIAGGGVIPHIHKSLIGKKGQQKTV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Acetylation	---MAGGKAGKDTGK ---CCCCCCCCCCCC	53.71	-
8	Acetylation	MAGGKAGKDTGKAKA CCCCCCCCCCCCCCC	57.91	-
12	Acetylation	KAGKDTGKAKATSIT CCCCCCCCCCCCCCC	49.13	-
12	Lactoylation	KAGKDTGKAKATSIT CCCCCCCCCCCCCCC	49.13	-
14	Lactoylation	GKDTGKAKATSITRS CCCCCCCCCCCCCHH	56.54	-
116	Lactoylation	GVIPHIHKSLIGKKG CCCHHHHHHHCCCCC	46.48	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of H2AZL_XENLA !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of H2AZL_XENLA !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of H2AZL_XENLA !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of H2AZL_XENLA !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of H2AZL_XENLA

Related Literatures of Post-Translational Modification