H1T_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: H1T_RAT
• UniProt AC: P06349
• Protein Name: Histone H1t
• Gene Name: Hist1h1t
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 208
• Subcellular Localization: Nucleus . Chromosome .
• Protein Description: Testis-specific histone H1 that forms less compacted chromatin compared to other H1 histone subtypes. Formation of more relaxed chromatin may be required to promote chromatin architecture required for proper chromosome regulation during meiosis, such as homologous recombination. Histones H1 act as linkers that bind to nucleosomes and compact polynucleosomes into a higher-order chromatin configuration..
• Protein Sequence: MSETAPAASSTLVPAPVEKPATKRRGKKPGMATARKPRGFSVSKLIPEALSMSQERAGMSLAALKKALAAAGYDVEKNNSRIKLALKRLVNKGVLVQTKGTGASGSFKLSKKAASGNDKGKGKKSASAKAKKLGLSRASRSPKSSKTKVVKKPKATPTKGSGSRRKTKGAKGLQQRKSPAKARATNSNSGKSKMVMQKTDLRKAAGRK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSETAPAAS ------CCCCCCCCC	43.59	22673903
4	Phosphorylation	----MSETAPAASST ----CCCCCCCCCCC	30.54	22673903
9	Phosphorylation	SETAPAASSTLVPAP CCCCCCCCCCCCCCC	26.43	22673903
10	Phosphorylation	ETAPAASSTLVPAPV CCCCCCCCCCCCCCC	22.49	22673903
11	Phosphorylation	TAPAASSTLVPAPVE CCCCCCCCCCCCCCC	29.31	22673903
19	Acetylation	LVPAPVEKPATKRRG CCCCCCCCCCCCCCC	39.94	22902405
28	Acetylation	ATKRRGKKPGMATAR CCCCCCCCCCCCCCC	50.02	22902405
56	Citrullination	ALSMSQERAGMSLAA HHHCCHHHHCCCHHH	28.89	-
56	Citrullination	ALSMSQERAGMSLAA HHHCCHHHHCCCHHH	28.89	-
66	Ubiquitination	MSLAALKKALAAAGY CCHHHHHHHHHHCCC	49.86	-
77	Ubiquitination	AAGYDVEKNNSRIKL HCCCCCHHCCHHHHH	62.37	-
77	Acetylation	AAGYDVEKNNSRIKL HCCCCCHHCCHHHHH	62.37	25786129
80	Phosphorylation	YDVEKNNSRIKLALK CCCHHCCHHHHHHHH	44.79	23800682
92	Acetylation	ALKRLVNKGVLVQTK HHHHHHHCCCEEEEC	42.80	22902405
101	Phosphorylation	VLVQTKGTGASGSFK CEEEECCCCCCCCEE	31.00	30181290
104	Phosphorylation	QTKGTGASGSFKLSK EECCCCCCCCEEECC	35.99	28432305
106	Phosphorylation	KGTGASGSFKLSKKA CCCCCCCCEEECCCC	19.40	28432305
141	Phosphorylation	GLSRASRSPKSSKTK CCCCCCCCCCCCCCC	33.90	19043117
156	Phosphorylation	VVKKPKATPTKGSGS EECCCCCCCCCCCCC	37.30	19043117
163	Phosphorylation	TPTKGSGSRRKTKGA CCCCCCCCCCCCCCC	30.52	-
178	Phosphorylation	KGLQQRKSPAKARAT HHHHHCCCCHHHHCC	32.07	19043117
187	Phosphorylation	AKARATNSNSGKSKM HHHHCCCCCCCCCCE	28.19	17052712
198	Acetylation	KSKMVMQKTDLRKAA CCCEEEEHHHHHHHH	26.38	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of H1T_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
56	R	Citrullination	Citrullination at Arg-56 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of H1T_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of H1T_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.