H1T_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: H1T_MOUSE
• UniProt AC: Q07133
• Protein Name: Histone H1t
• Gene Name: Hist1h1t
• Organism: Mus musculus (Mouse).
• Sequence Length: 208
• Subcellular Localization: Nucleus . Chromosome .
• Protein Description: Testis-specific histone H1 that forms less compacted chromatin compared to other H1 histone subtypes. Formation of more relaxed chromatin may be required to promote chromatin architecture required for proper chromosome regulation during meiosis, such as homologous recombination. Histones H1 act as linkers that bind to nucleosomes and compact polynucleosomes into a higher-order chromatin configuration..
• Protein Sequence: MSETAPAASSTLVPAPVEKPSSKRRGKKPGLAPARKPRGFSVSKLIPEALSTSQERAGMSLAALKKALAAAGYDVEKNNSRIKLALKRLVNKGVLVQTKGTGASGSFKLSKKAASGNDKGKGKKSASAKAKKMGLPRASRSPKSSKTKAVKKPKATPTKASGSGRKTKGAKGVQQRKSPAKARAANPNSGKAKMVMQKTDLRKAAGRK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	SETAPAASSTLVPAP CCCCCCCCCCCCCCC	26.43	22817900
28	Acetylation	SSKRRGKKPGLAPAR CCCCCCCCCCCCCCC	47.33	17043054
56	Citrullination	ALSTSQERAGMSLAA HHCCCHHHHCCCHHH	28.89	-
56	Citrullination	ALSTSQERAGMSLAA HHCCCHHHHCCCHHH	28.89	-
60	Phosphorylation	SQERAGMSLAALKKA CHHHHCCCHHHHHHH	17.59	29899451
66	Succinylation	MSLAALKKALAAAGY CCHHHHHHHHHHCCC	49.86	23806337
66	Acetylation	MSLAALKKALAAAGY CCHHHHHHHHHHCCC	49.86	23806337
66	Ubiquitination	MSLAALKKALAAAGY CCHHHHHHHHHHCCC	49.86	-
73	Phosphorylation	KALAAAGYDVEKNNS HHHHHCCCCCHHCCH	16.46	26026062
77	Acetylation	AAGYDVEKNNSRIKL HCCCCCHHCCHHHHH	62.37	158565
77	Ubiquitination	AAGYDVEKNNSRIKL HCCCCCHHCCHHHHH	62.37	-
80	Phosphorylation	YDVEKNNSRIKLALK CCCHHCCHHHHHHHH	44.79	29176673
98	Phosphorylation	NKGVLVQTKGTGASG HCCCEEEECCCCCCC	24.78	-
101	Phosphorylation	VLVQTKGTGASGSFK CEEEECCCCCCCCEE	31.00	29899451
104	Phosphorylation	QTKGTGASGSFKLSK EECCCCCCCCEEECC	35.99	28542873
106	Phosphorylation	KGTGASGSFKLSKKA CCCCCCCCEEECCCC	19.40	23684622
111	Methylation	SGSFKLSKKAASGND CCCEEECCCCCCCCC	57.79	-
111	"N6,N6-dimethyllysine"	SGSFKLSKKAASGND CCCEEECCCCCCCCC	57.79	-
127	Phosphorylation	GKGKKSASAKAKKMG CCCCHHHHHHHHHCC	37.08	22802335
141	Phosphorylation	GLPRASRSPKSSKTK CCCCCCCCCCCCCCC	33.90	18698803
156	Phosphorylation	AVKKPKATPTKASGS CCCCCCCCCCCCCCC	37.30	18698803
163	Phosphorylation	TPTKASGSGRKTKGA CCCCCCCCCCCCCCC	32.69	18698803
167	Phosphorylation	ASGSGRKTKGAKGVQ CCCCCCCCCCCCCCC	33.09	19854140
178	Phosphorylation	KGVQQRKSPAKARAA CCCCCCCCHHHHHHC	32.07	18698803
199	Phosphorylation	AKMVMQKTDLRKAAG HCHHCCHHHHHHHHC	24.31	28576409

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of H1T_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
56	R	Citrullination	Citrullination at Arg-56 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of H1T_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of H1T_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.