H12_BOVIN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: H12_BOVIN
• UniProt AC: P02253
• Protein Name: Histone H1.2
• Gene Name: HIST1H1C
• Organism: Bos taurus (Bovine).
• Sequence Length: 213
• Subcellular Localization: Nucleus. Chromosome. Mainly localizes in euchromatin..
• Protein Description: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity)..
• Protein Sequence: MSETAPAAPAAAPPAEKTPVKKKAAKKPAGARRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAATGEAKPKAKKAGAAKPKKAAGAAKKTKKATGAATPKKTAKKTPKKAKKPAAAAVTKKVAKSPKKAKAAKPKKAAKSAAKAVKPKAAKPKVAKPKKAAPKKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSETAPAAP ------CCCCCCCCC		-
2	Phosphorylation	------MSETAPAAP ------CCCCCCCCC		-
17	Acetylation	AAAPPAEKTPVKKKA CCCCCHHHCCCCHHH		-
18	Phosphorylation	AAPPAEKTPVKKKAA CCCCHHHCCCCHHHC		-
23	Other	EKTPVKKKAAKKPAG HHCCCCHHHCCCCCC		-
26	Methylation	PVKKKAAKKPAGARR CCCHHHCCCCCCCCC		-
26	Acetylation	PVKKKAAKKPAGARR CCCHHHCCCCCCCCC		-
26	Other	PVKKKAAKKPAGARR CCCHHHCCCCCCCCC		-
27	Other	VKKKAAKKPAGARRK CCHHHCCCCCCCCCC		-
34	Crotonylation	KPAGARRKASGPPVS CCCCCCCCCCCCCHH		-
34	Other	KPAGARRKASGPPVS CCCCCCCCCCCCCHH		-
34	N6-crotonyl-L-lysine	KPAGARRKASGPPVS CCCCCCCCCCCCCHH		-
34	Methylation	KPAGARRKASGPPVS CCCCCCCCCCCCCHH		-
35	Phosphorylation	PAGARRKASGPPVSE CCCCCCCCCCCCHHH		1137958
36	Phosphorylation	AGARRKASGPPVSEL CCCCCCCCCCCHHHH		1137958
41	Phosphorylation	KASGPPVSELITKAV CCCCCCHHHHHHHHH		-
46	Acetylation	PVSELITKAVAASKE CHHHHHHHHHHHCHH		-
46	Other	PVSELITKAVAASKE CHHHHHHHHHHHCHH		-
52	Other	TKAVAASKERSGVSL HHHHHHCHHCCCCCH		-
54	Citrullination	AVAASKERSGVSLAA HHHHCHHCCCCCHHH		-
54	Citrullination	AVAASKERSGVSLAA HHHHCHHCCCCCHHH		-
63	Other	GVSLAALKKALAAAG CCCHHHHHHHHHHCC		-
64	N6-crotonyl-L-lysine	VSLAALKKALAAAGY CCHHHHHHHHHHCCC		-
64	Other	VSLAALKKALAAAGY CCHHHHHHHHHHCCC		-
64	Crotonylation	VSLAALKKALAAAGY CCHHHHHHHHHHCCC		-
75	Other	AAGYDVEKNNSRIKL HCCCCCHHCCCCCCC		-
75	Acetylation	AAGYDVEKNNSRIKL HCCCCCHHCCCCCCC		-
81	Other	EKNNSRIKLGLKSLV HHCCCCCCCCHHHHH		-
85	Crotonylation	SRIKLGLKSLVSKGT CCCCCCHHHHHHCCC		-
85	Other	SRIKLGLKSLVSKGT CCCCCCHHHHHHCCC		-
85	N6-crotonyl-L-lysine	SRIKLGLKSLVSKGT CCCCCCHHHHHHCCC		-
90	Crotonylation	GLKSLVSKGTLVQTK CHHHHHHCCCEEEEC		-
90	Other	GLKSLVSKGTLVQTK CHHHHHHCCCEEEEC		-
90	Acetylation	GLKSLVSKGTLVQTK CHHHHHHCCCEEEEC		-
90	N6-crotonyl-L-lysine	GLKSLVSKGTLVQTK CHHHHHHCCCEEEEC		-
97	Succinylation	KGTLVQTKGTGASGS CCCEEEECCCCCCCC		-
97	N6-crotonyl-L-lysine	KGTLVQTKGTGASGS CCCEEEECCCCCCCC		-
97	Crotonylation	KGTLVQTKGTGASGS CCCEEEECCCCCCCC		-
97	Other	KGTLVQTKGTGASGS CCCEEEECCCCCCCC		-
103	Phosphorylation	TKGTGASGSFKLNKK ECCCCCCCCEEECCC		3134256
104	Phosphorylation	KGTGASGSFKLNKKA CCCCCCCCEEECCCC		3134256
106	Other	TGASGSFKLNKKAAT CCCCCCEEECCCCCC		-
110	Other	GSFKLNKKAATGEAK CCEEECCCCCCCCCC		-
117	Other	KAATGEAKPKAKKAG CCCCCCCCHHHHHCC		-
121	Other	GEAKPKAKKAGAAKP CCCCHHHHHCCCCCC		-
129	Other	KAGAAKPKKAAGAAK HCCCCCCCHHHCCCH		-
136	Other	KKAAGAAKKTKKATG CHHHCCCHHCCCCCC		-
146	Phosphorylation	KKATGAATPKKTAKK CCCCCCCCCCCCCCC		-
148	Other	ATGAATPKKTAKKTP CCCCCCCCCCCCCCC		-
154	Phosphorylation	PKKTAKKTPKKAKKP CCCCCCCCCCCCCCH		-
159	Crotonylation	KKTPKKAKKPAAAAV CCCCCCCCCHHHHHH		-
159	N6-crotonyl-L-lysine	KKTPKKAKKPAAAAV CCCCCCCCCHHHHHH		-
159	Other	KKTPKKAKKPAAAAV CCCCCCCCCHHHHHH		-
168	Crotonylation	PAAAAVTKKVAKSPK HHHHHHHHHHHCCHH		-
168	Acetylation	PAAAAVTKKVAKSPK HHHHHHHHHHHCCHH		-
168	N6-crotonyl-L-lysine	PAAAAVTKKVAKSPK HHHHHHHHHHHCCHH		-
168	Other	PAAAAVTKKVAKSPK HHHHHHHHHHHCCHH		-
173	Phosphorylation	VTKKVAKSPKKAKAA HHHHHHCCHHHHHHC		-
187	Methylation	AKPKKAAKSAAKAVK CCHHHHHHHHHHHHC		-
188	ADP-ribosylation	KPKKAAKSAAKAVKP CHHHHHHHHHHHHCC		-
188	Phosphorylation	KPKKAAKSAAKAVKP CHHHHHHHHHHHHCC		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
35	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
35	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM
36	S	Phosphorylation	Kinase	PRKACA	P00517	GPS
36	S	Phosphorylation	Kinase	PRKG1	P00516	GPS
36	S	Phosphorylation	Kinase	PKG1	Q13976	PSP
36	S	Phosphorylation	Kinase	PRKCA	P04409	GPS
103	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
103	S	Phosphorylation	Kinase	PKC_GROUP	-	PhosphoELM
104	S	Phosphorylation	Kinase	PRKCA	P05696	GPS
104	S	Phosphorylation	Kinase	PKC	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of H12_BOVIN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of H12_BOVIN !!

Protein-Protein Interaction

Oops, there are no PPI records of H12_BOVIN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.