H11_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: H11_RAT
• UniProt AC: D4A3K5
• Protein Name: Histone H1.1
• Gene Name: Hist1h1a
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 214
• Subcellular Localization: Nucleus . Chromosome . Mainly localizes in euchromatin..
• Protein Description: H1 histones bind to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. H1 histones are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling (By similarity)..
• Protein Sequence: MSETAPVPQPASVAPEKPAATKKTRKPAKAAVPRKKPAGPSVSELIVQAVSSSKERSGVSLAALKKSLAAAGYDVEKNNSRIKLGLKSLVNKGTLVQTKGTGAAGSFKLNKKAESKASTTKVTVKAKASGAAKKPKKTAGAAAKKTVKTPKKPKKPAVSKKTSSKSPKKPKVVKAKKVAKSPAKAKAVKPKAAKVKVTKPKTPAKPKKAAPKKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSETAPVPQ ------CCCCCCCCC		-
2	Phosphorylation	------MSETAPVPQ ------CCCCCCCCC		27097102
4	Phosphorylation	----MSETAPVPQPA ----CCCCCCCCCCC		27097102
12	Phosphorylation	APVPQPASVAPEKPA CCCCCCCCCCCCCCC		27097102
17	Acetylation	PASVAPEKPAATKKT CCCCCCCCCCCCCCC		22902405
22	Acetylation	PEKPAATKKTRKPAK CCCCCCCCCCCCCCH		22902405
36	Other	KAAVPRKKPAGPSVS HHCCCCCCCCCCCHH		-
41	Phosphorylation	RKKPAGPSVSELIVQ CCCCCCCCHHHHHHH		28432305
43	Phosphorylation	KPAGPSVSELIVQAV CCCCCCHHHHHHHHH		28432305
54	Other	VQAVSSSKERSGVSL HHHHHCCCCCCCCCH		-
56	Citrullination	AVSSSKERSGVSLAA HHHCCCCCCCCCHHH		-
56	Citrullination	AVSSSKERSGVSLAA HHHCCCCCCCCCHHH		-
57	Phosphorylation	VSSSKERSGVSLAAL HHCCCCCCCCCHHHH		27097102
60	Phosphorylation	SKERSGVSLAALKKS CCCCCCCCHHHHHHH		28432305
65	Acetylation	GVSLAALKKSLAAAG CCCHHHHHHHHHHCC		22902405
66	Other	VSLAALKKSLAAAGY CCHHHHHHHHHHCCC		-
67	Phosphorylation	SLAALKKSLAAAGYD CHHHHHHHHHHCCCC		22673903
77	Acetylation	AAGYDVEKNNSRIKL HCCCCCCCCCCEEEE		-
80	Phosphorylation	YDVEKNNSRIKLGLK CCCCCCCCEEEECHH		23800682
87	Other	SRIKLGLKSLVNKGT CEEEECHHHHHHCCC		-
87	Acetylation	SRIKLGLKSLVNKGT CEEEECHHHHHHCCC		22902405
92	Other	GLKSLVNKGTLVQTK CHHHHHHCCCEEEEC		-
92	Acetylation	GLKSLVNKGTLVQTK CHHHHHHCCCEEEEC		-
106	Phosphorylation	KGTGAAGSFKLNKKA CCCCCCCCEECCHHH		28432305
108	Other	TGAAGSFKLNKKAES CCCCCCEECCHHHCC		-
108	Acetylation	TGAAGSFKLNKKAES CCCCCCEECCHHHCC		22902405
121	Acetylation	ESKASTTKVTVKAKA CCCCCCCEEEEEEEC		-
202	Phosphorylation	VKVTKPKTPAKPKKA CEECCCCCCCCCCCC		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of H11_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
56	R	Citrullination	Citrullination at Arg-56 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of H11_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of H11_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.