GTR1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GTR1_RAT
• UniProt AC: P11167
• Protein Name: Solute carrier family 2, facilitated glucose transporter member 1
• Gene Name: Slc2a1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 492
• Subcellular Localization: Cell membrane; Multi-pass membrane protein. Melanosome. Localizes primarily at the cell surface..
• Protein Description: Facilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses (By similarity)..
• Protein Sequence: MEPSSKKVTGRLMLAVGGAVLGSLQFGYNTGVINAPQKVIEEFYNQTWNHRYGESIPSTTLTTLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLMMNLLAFVSAVLMGFSKLGKSFEMLILGRFIIGVYCGLTTGFVPMYVGEVSPTALRGALGTLHQLGIVVGILIAQVFGLDSIMGNADLWPLLLSVIFIPALLQCILLPFCPESPRFLLINRNEENRAKSVLKKLRGTADVTRDLQEMKEEGRQMMREKKVTILELFRSPAYRQPILIAVVLQLSQQLSGINAVFYYSTSIFEKAGVQQPVYATIGSGIVNTAFTVVSLFVVERAGRRTLHLIGLAGMAGCAVLMTIALALLEQLPWMSYLSIVAIFGFVAFFEVGPGPIPWFIVAELFSQGPRPAAVAVAGFSNWTSNFIVGMCFQYVEQLCGPYVFIIFTVLLVLFFIFTYFKVPETKGRTFDEIASGFRQGGASQSDKTPEELFHPLGADSQV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEPSSKKV -------CCCCCHHC	18.03	-
45	N-linked_Glycosylation	KVIEEFYNQTWNHRY HHHHHHHHHHCCCCC	37.82	-
226	Phosphorylation	NEENRAKSVLKKLRG CHHHHHHHHHHHHHC	31.53	-
245	Ubiquitination	TRDLQEMKEEGRQMM HHHHHHHHHHHHHHH	52.43	-
465	Phosphorylation	RTFDEIASGFRQGGA CCHHHHHHHHHCCCC	44.09	-
473	Phosphorylation	GFRQGGASQSDKTPE HHHCCCCCCCCCCHH	33.23	22673903
475	Phosphorylation	RQGGASQSDKTPEEL HCCCCCCCCCCHHHH	38.28	22673903
477	Ubiquitination	GGASQSDKTPEELFH CCCCCCCCCHHHHCC	71.83	-
478	Phosphorylation	GASQSDKTPEELFHP CCCCCCCCHHHHCCC	40.71	30240740
490	Phosphorylation	FHPLGADSQV----- CCCCCCCCCC-----	32.10	23984901

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
226	S	Phosphorylation	Kinase	PRKCB	P05771	GPS
226	S	Phosphorylation	Kinase	PKCB	P68403	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
226	S	Phosphorylation	Phosphorylation at Ser-226 by PKC promotes glucose uptake by increasing cell membrane localization.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GTR1_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBC_RAT	Ubc	physical	15359219

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.