GSTO1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GSTO1_MOUSE
• UniProt AC: O09131
• Protein Name: Glutathione S-transferase omega-1
• Gene Name: Gsto1
• Organism: Mus musculus (Mouse).
• Sequence Length: 240
• Subcellular Localization: Cytoplasm, cytosol .
• Protein Description: Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid..
• Protein Sequence: MSGESSRSLGKGSAPPGPVPEGQIRVYSMRFCPFAQRTLMVLKAKGIRHEVININLKNKPEWFFEKNPLGLVPVLENSQGHLVTESVITCEYLDEAYPEKKLFPDDPYKKARQKMTLESFSKVPPLIASFVRSKRKEDSPNLREALENEFKKLEEGMDNYKSFLGGDSPSMVDYLTWPWFQRLEALELKECLAHTPKLKLWMAAMQQDPVASSHKIDAKTYREYLNLYLQDSPEACDYGL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSGESSRSL ------CCCCCCCCC	51.79	-
8	Phosphorylation	MSGESSRSLGKGSAP CCCCCCCCCCCCCCC	43.34	29514104
11	Ubiquitination	ESSRSLGKGSAPPGP CCCCCCCCCCCCCCC	55.79	27667366
11	Malonylation	ESSRSLGKGSAPPGP CCCCCCCCCCCCCCC	55.79	26320211
13	Phosphorylation	SRSLGKGSAPPGPVP CCCCCCCCCCCCCCC	40.88	27180971
32	S-nitrosocysteine	RVYSMRFCPFAQRTL EEEEEEECHHHHHHH	1.59	-
32	S-nitrosylation	RVYSMRFCPFAQRTL EEEEEEECHHHHHHH	1.59	21278135
32	Glutathionylation	RVYSMRFCPFAQRTL EEEEEEECHHHHHHH	1.59	24333276
43	Acetylation	QRTLMVLKAKGIRHE HHHHHHHHHCCCCEE	36.32	22826441
43	Ubiquitination	QRTLMVLKAKGIRHE HHHHHHHHHCCCCEE	36.32	27667366
57	Acetylation	EVININLKNKPEWFF EEEEEECCCCCHHHC	59.44	22826441
90	S-nitrosylation	VTESVITCEYLDEAY EEEEEEEHHHHCHHC	1.91	21278135
90	S-nitrosocysteine	VTESVITCEYLDEAY EEEEEEEHHHHCHHC	1.91	-
101	Ubiquitination	DEAYPEKKLFPDDPY CHHCCCCCCCCCCHH	54.41	22790023
109	Succinylation	LFPDDPYKKARQKMT CCCCCHHHHHHHHCC	45.40	23954790
109	Acetylation	LFPDDPYKKARQKMT CCCCCHHHHHHHHCC	45.40	23201123
119	Phosphorylation	RQKMTLESFSKVPPL HHHCCHHHHHCCHHH	37.62	22817900
121	Phosphorylation	KMTLESFSKVPPLIA HCCHHHHHCCHHHHH	41.86	22817900
122	Ubiquitination	MTLESFSKVPPLIAS CCHHHHHCCHHHHHH	57.67	22790023
129	Phosphorylation	KVPPLIASFVRSKRK CCHHHHHHHHHHCCC	19.79	26824392
139	Phosphorylation	RSKRKEDSPNLREAL HHCCCCCCCCHHHHH	19.44	29899451
151	Succinylation	EALENEFKKLEEGMD HHHHHHHHHHHHCHH	50.71	23954790
151	Acetylation	EALENEFKKLEEGMD HHHHHHHHHHHHCHH	50.71	23954790
152	Ubiquitination	ALENEFKKLEEGMDN HHHHHHHHHHHCHHH	67.46	22790023
152	Acetylation	ALENEFKKLEEGMDN HHHHHHHHHHHCHHH	67.46	-
160	Phosphorylation	LEEGMDNYKSFLGGD HHHCHHHHHHHHCCC	12.07	22817900
189	Malonylation	RLEALELKECLAHTP HHHHHCHHHHHHCCH	36.69	26320211
189	Ubiquitination	RLEALELKECLAHTP HHHHHCHHHHHHCCH	36.69	-
189	Acetylation	RLEALELKECLAHTP HHHHHCHHHHHHCCH	36.69	22733758
191	S-nitrosylation	EALELKECLAHTPKL HHHCHHHHHHCCHHH	3.78	20925432
191	S-palmitoylation	EALELKECLAHTPKL HHHCHHHHHHCCHHH	3.78	26165157
191	S-nitrosocysteine	EALELKECLAHTPKL HHHCHHHHHHCCHHH	3.78	-
219	Malonylation	SSHKIDAKTYREYLN CCCCCCHHHHHHHHH	42.20	26320211
228	Phosphorylation	YREYLNLYLQDSPEA HHHHHHHHHCCCHHH	10.97	-
236	S-nitrosocysteine	LQDSPEACDYGL--- HCCCHHHCCCCC---	3.84	-
236	S-nitrosylation	LQDSPEACDYGL--- HCCCHHHCCCCC---	3.84	21278135

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GSTO1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GSTO1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GSTO1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of GSTO1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.