GSTM2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GSTM2_MOUSE
• UniProt AC: P15626
• Protein Name: Glutathione S-transferase Mu 2
• Gene Name: Gstm2
• Organism: Mus musculus (Mouse).
• Sequence Length: 218
• Subcellular Localization: Cytoplasm.
• Protein Description: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles..
• Protein Sequence: MPMTLGYWDIRGLAHAIRLLLEYTDTSYEDKKYTMGDAPDYDRSQWLSEKFKLGLDFPNLPYLIDGSHKITQSNAILRYLARKHNLCGETEEERIRVDILENQAMDTRIQLAMVCYSPDFEKKKPEYLEGLPEKMKLYSEFLGKQPWFAGNKVTYVDFLVYDVLDQHRIFEPKCLDAFPNLKDFMGRFEGLKKISDYMKSSRFLSKPIFAKMAFWNPK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Phosphorylation	LLEYTDTSYEDKKYT HHHCCCCCHHCCCCC	29.36	-
31	Acetylation	TDTSYEDKKYTMGDA CCCCHHCCCCCCCCC	35.42	19864859
31	Ubiquitination	TDTSYEDKKYTMGDA CCCCHHCCCCCCCCC	35.42	22790023
32	Acetylation	DTSYEDKKYTMGDAP CCCHHCCCCCCCCCC	59.27	22826441
34	Phosphorylation	SYEDKKYTMGDAPDY CHHCCCCCCCCCCCC	24.45	20139300
44	Phosphorylation	DAPDYDRSQWLSEKF CCCCCCHHHHHHHHH	23.86	-
50	Ubiquitination	RSQWLSEKFKLGLDF HHHHHHHHHCCCCCC	44.41	22790023
52	Acetylation	QWLSEKFKLGLDFPN HHHHHHHCCCCCCCC	53.35	7872623
52	Ubiquitination	QWLSEKFKLGLDFPN HHHHHHHCCCCCCCC	53.35	22790023
62	Phosphorylation	LDFPNLPYLIDGSHK CCCCCCCEEECCCCC	21.32	23984901
67	Phosphorylation	LPYLIDGSHKITQSN CCEEECCCCCCCCHH	20.19	21082442
69	Acetylation	YLIDGSHKITQSNAI EEECCCCCCCCHHHH	49.50	7872633
69	Ubiquitination	YLIDGSHKITQSNAI EEECCCCCCCCHHHH	49.50	-
71	Phosphorylation	IDGSHKITQSNAILR ECCCCCCCCHHHHHH	30.65	23984901
73	Phosphorylation	GSHKITQSNAILRYL CCCCCCCHHHHHHHH	21.41	23984901
83	Ubiquitination	ILRYLARKHNLCGET HHHHHHHHCCCCCCC	31.10	22790023
87	S-nitrosylation	LARKHNLCGETEEER HHHHCCCCCCCHHHH	5.85	21278135
87	S-nitrosocysteine	LARKHNLCGETEEER HHHHCCCCCCCHHHH	5.85	-
115	S-nitrosylation	RIQLAMVCYSPDFEK HHHHHHHHHCCCHHH	1.46	21278135
115	S-nitrosocysteine	RIQLAMVCYSPDFEK HHHHHHHHHCCCHHH	1.46	-
117	Phosphorylation	QLAMVCYSPDFEKKK HHHHHHHCCCHHHCC	16.93	26643407
136	Malonylation	EGLPEKMKLYSEFLG CCCCHHHHHHHHHHC	56.17	26320211
136	Acetylation	EGLPEKMKLYSEFLG CCCCHHHHHHHHHHC	56.17	22733758
136	Ubiquitination	EGLPEKMKLYSEFLG CCCCHHHHHHHHHHC	56.17	-
139	Phosphorylation	PEKMKLYSEFLGKQP CHHHHHHHHHHCCCC	32.10	26643407
144	Acetylation	LYSEFLGKQPWFAGN HHHHHHCCCCCCCCC	56.16	23954790
144	Ubiquitination	LYSEFLGKQPWFAGN HHHHHHCCCCCCCCC	56.16	22790023
173	Acetylation	QHRIFEPKCLDAFPN HCCCCCHHHHHHCCC	39.99	22733758
174	S-nitrosylation	HRIFEPKCLDAFPNL CCCCCHHHHHHCCCH	6.43	21278135
174	S-nitrosocysteine	HRIFEPKCLDAFPNL CCCCCHHHHHHCCCH	6.43	-
192	Acetylation	MGRFEGLKKISDYMK HHHHHHHHHHHHHHH	59.94	2372787
199	Malonylation	KKISDYMKSSRFLSK HHHHHHHHHHCCCCC	38.76	26320211
199	Acetylation	KKISDYMKSSRFLSK HHHHHHHHHHCCCCC	38.76	23954790
205	Phosphorylation	MKSSRFLSKPIFAKM HHHHCCCCCCHHHHH	33.40	-
206	Ubiquitination	KSSRFLSKPIFAKMA HHHCCCCCCHHHHHH	44.26	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GSTM2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GSTM2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GSTM2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of GSTM2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.