GSTA1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GSTA1_MOUSE
• UniProt AC: P13745
• Protein Name: Glutathione S-transferase A1
• Gene Name: Gsta1
• Organism: Mus musculus (Mouse).
• Sequence Length: 223
• Protein Description: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles..
• Protein Sequence: MAGKPVLHYFNARGRMECIRWLLAAAGVEFEEKFIQSPEDLEKLKKDGNLMFDQVPMVEIDGMKLAQTRAILNYIATKYDLYGKDMKERALIDMYSEGILDLTEMIGQLVLCPPDQREAKTALAKDRTKNRYLPAFEKVLKSHGQDYLVGNRLTRVDIHLLEVLLYVEEFDASLLTPFPLLKAFKSRISSLPNVKKFLQPGSQRKPPMDAKQIQEARKAFKIQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MAGKPVLH -------CCCCCCHH	11.35	-
2	Acetylation	------MAGKPVLHY ------CCCCCCHHC	34.42	-
4	Acetylation	----MAGKPVLHYFN ----CCCCCCHHCCC	23.55	51082611
4	Succinylation	----MAGKPVLHYFN ----CCCCCCHHCCC	23.55	-
4	Succinylation	----MAGKPVLHYFN ----CCCCCCHHCCC	23.55	-
37	Phosphorylation	FEEKFIQSPEDLEKL HHHHHCCCHHHHHHH	25.99	22817900
43	Acetylation	QSPEDLEKLKKDGNL CCHHHHHHHHHHCCC	73.27	66691533
78	Acetylation	ILNYIATKYDLYGKD HHHHHHHHHHHCCCC	27.96	66695823
84	Acetylation	TKYDLYGKDMKERAL HHHHHCCCCHHHHHH	40.88	66698527
84	Ubiquitination	TKYDLYGKDMKERAL HHHHHCCCCHHHHHH	40.88	27667366
84	Malonylation	TKYDLYGKDMKERAL HHHHHCCCCHHHHHH	40.88	26073543
132	Phosphorylation	KDRTKNRYLPAFEKV HHHHHCCCHHHHHHH	26.82	25195567
138	Ubiquitination	RYLPAFEKVLKSHGQ CCHHHHHHHHHHCCC	46.55	-
141	Ubiquitination	PAFEKVLKSHGQDYL HHHHHHHHHCCCCCC	43.31	27667366
141	Acetylation	PAFEKVLKSHGQDYL HHHHHHHHHCCCCCC	43.31	38024089
142	Phosphorylation	AFEKVLKSHGQDYLV HHHHHHHHCCCCCCC	28.79	26239621
147	Phosphorylation	LKSHGQDYLVGNRLT HHHCCCCCCCCCCCC	8.73	26032504
186	Phosphorylation	PLLKAFKSRISSLPN HHHHHHHHHHHCCCC	28.52	25195567
190	Phosphorylation	AFKSRISSLPNVKKF HHHHHHHCCCCHHHH	45.54	25195567
195	Malonylation	ISSLPNVKKFLQPGS HHCCCCHHHHCCCCC	44.44	26073543
195	Acetylation	ISSLPNVKKFLQPGS HHCCCCHHHHCCCCC	44.44	15626895
195	Ubiquitination	ISSLPNVKKFLQPGS HHCCCCHHHHCCCCC	44.44	-
196	Ubiquitination	SSLPNVKKFLQPGSQ HCCCCHHHHCCCCCC	47.20	-
196	Malonylation	SSLPNVKKFLQPGSQ HCCCCHHHHCCCCCC	47.20	26320211
196	Acetylation	SSLPNVKKFLQPGSQ HCCCCHHHHCCCCCC	47.20	22733758
196	Glutarylation	SSLPNVKKFLQPGSQ HCCCCHHHHCCCCCC	47.20	24703693
202	Phosphorylation	KKFLQPGSQRKPPMD HHHCCCCCCCCCCCC	33.23	30352176

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GSTA1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GSTA1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GSTA1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of GSTA1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.