GSLG1_CAEEL - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GSLG1_CAEEL
• UniProt AC: Q19459
• Protein Name: Golgi apparatus protein 1 homolog
• Gene Name: F14E5.2
• Organism: Caenorhabditis elegans.
• Sequence Length: 1149
• Subcellular Localization: Membrane ; Single-pass type I membrane protein .
• Protein Sequence: MWRFPLILASVCWLTTAQQQNVANDPDKKLASFDACKADIHKHCSRPDVDLTSDMSILECLQDAGFSETATLSEQCEQLVWDFKVKITQDERFVSAAKQYCEEELKGNAAMNLCTSQTQPGFALSCLMEFTKNVTETGKCHAFLARTERLAFSDFRLVGPFVTKCRAILDKFKCNVLTPDPAHKGVRVAHTQGMALECILDKVVKNAKTQADALQILGDDCKHEVLRLAEMQADDFHLDRPLFFACRLDRERYCKDVPSGEGKVFECLMMNRNDKFMDPECGNLLAERAYLMGRDYRMAHPLTKACQPELTRYKCEPQNQIESAAHFHLAWILLCLENGANQPEHKEVQPSKECAHEMITHRQMMMQHFRMAPELVLNCAQEIDKWCSPRGDIEAEGRTLHCLMEHAESRNETLKLGAQCLQAVQQVVKVADIGRNYKVDKVLYGSCRSLIDGPCAQDAVSETATLTCLMRNVDSPDMVPECEKRLLEVQYFMARDWTMDPQLYEACHQEAVSRCSALDNWHQQHNSDNTVDRGPQVLACLYRSAYDEQNPLSVKCGTQVRQLLHVRAVRVNLIPEIEDSCREALSEFCSHNVKPSEEMMCLQQNFETDNFKRKHPQCFAELTKFTEMEAKDTKLNRALSKACKPVISTHCAQFANEEIDHGDVLECLVNNKDAKEMNNKCRSYVNHFELISLRDYHFSYKFQKACASDIEQSCKGHNNDKGEIIRCLSEVRFEHKVLGSPKDLTDDCKKQLKVAYLQQEQVEFDDKEHMADADPKLSQKCEQEIKMYKCNQADTFEDTIECLRLNFEHLGPECKSMIFYREKIEAVDNSMDDELQKKCRYDIGKFCANSDSENVLECLTNTKIVRLLQRECKAIVKERMQESARDVRLRPQLLTSCRKEAEQYCPEDMKKINMPQYSQTVLDGVVVSCLRDKFRQSISDQNHIDFSPRCSAEVSRAIVEAEFDPQLDPPLYNACKSTINDHCSATIMESGGHFDNVMECLKNDFNKGLIRDKQCSEQVARRLQESLVDIHLDPVLHEACAMDIQRYCRDVPPGHSRIVMCLMDSADKQELSKECSTKLSDRNKLWMKAHSEFQMALPDSWHAFANLVMEHPERNSILGYLAGFIVFILLIGCCCGRVSKKQYIEMKNR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
133	N-linked_Glycosylation	CLMEFTKNVTETGKC HHHHHHCCCCCCCCC	42.77	-
411	N-linked_Glycosylation	MEHAESRNETLKLGA HHHHHHHHHHHHHHH	56.75	17761667
830	Phosphorylation	KIEAVDNSMDDELQK HHHHHCCCCCHHHHH	21.08	28854356
850	Phosphorylation	IGKFCANSDSENVLE HHHHHCCCCCCCHHH	24.80	30078680
1072	Phosphorylation	SADKQELSKECSTKL CCCHHHHHHHHHHHH	26.17	19530675
1076	Phosphorylation	QELSKECSTKLSDRN HHHHHHHHHHHHHHH	29.66	19530675
1077	Phosphorylation	ELSKECSTKLSDRNK HHHHHHHHHHHHHHC	47.89	19530675

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GSLG1_CAEEL !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GSLG1_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GSLG1_CAEEL !!

Protein-Protein Interaction

Oops, there are no PPI records of GSLG1_CAEEL !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Proteomics reveals N-linked glycoprotein diversity in Caenorhabditiselegans and suggests an atypical translocation mechanism for integralmembrane proteins.";
Kaji H., Kamiie J., Kawakami H., Kido K., Yamauchi Y., Shinkawa T.,Taoka M., Takahashi N., Isobe T.;
Mol. Cell. Proteomics 6:2100-2109(2007).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-411, AND MASSSPECTROMETRY.
PubMed: 17761667

"Lectin affinity capture, isotope-coded tagging and mass spectrometryto identify N-linked glycoproteins.";
Kaji H., Saito H., Yamauchi Y., Shinkawa T., Taoka M., Hirabayashi J.,Kasai K., Takahashi N., Isobe T.;
Nat. Biotechnol. 21:667-672(2003).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-411, AND MASSSPECTROMETRY.
PubMed: 12754521