GSDMC_HUMAN - dbPTM
GSDMC_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GSDMC_HUMAN
UniProt AC Q9BYG8
Protein Name Gasdermin-C
Gene Name GSDMC
Organism Homo sapiens (Human).
Sequence Length 508
Subcellular Localization Cytoplasm, cytosol . Cell membrane .
Protein Description The N-terminal moiety promotes pyroptosis. May be acting by homooligomerizing within the membrane and forming pores. [PubMed: 27281216 The physiological relevance of this observation is unknown (Probable]
Protein Sequence MPSMLERISKNLVKEIGSKDLTPVKYLLSATKLRQFVILRKKKDSRSSFWEQSDYVPVEFSLNDILEPSSSVLETVVTGPFHFSDIMIQKHKADMGVNVGIEVSVSGEASVDHGCSLEFQIVTIPSPNLEDFQKRKLLDPEPSFLKECRRRGDNLYVVTEAVELINNTVLYDSSSVNILGKIALWITYGKGQGQGESLRVKKKALTLQKGMVMAYKRKQLVIKEKAILISDDDEQRTFQDEYEISEMVGYCAARSEGLLPSFHTISPTLFNASSNDMKLKPELFLTQQFLSGHLPKYEQVHILPVGRIEEPFWQNFKHLQEEVFQKIKTLAQLSKDVQDVMFYSILAMLRDRGALQDLMNMLELDSSGHLDGPGGAILKKLQQDSNHAWFNPKDPILYLLEAIMVLSDFQHDLLACSMEKRILLQQQELVRSILEPNFRYPWSIPFTLKPELLAPLQSEGLAITYGLLEECGLRMELDNPRSTWDVEAKMPLSALYGTLSLLQQLAEA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MPSMLERISK
-----CCCHHHHHHH		34.4029978859
26PhosphorylationKDLTPVKYLLSATKL
CCCCCHHHHHHHHCC		17.0720393185
47PhosphorylationRKKKDSRSSFWEQSD
EECCCCCCCCCCCCC		33.5622468782
53PhosphorylationRSSFWEQSDYVPVEF
CCCCCCCCCCCEEEE		21.2822468782
55PhosphorylationSFWEQSDYVPVEFSL
CCCCCCCCCEEEEEH		16.3522468782
61PhosphorylationDYVPVEFSLNDILEP
CCCEEEEEHHHHCCC		16.8622468782
70PhosphorylationNDILEPSSSVLETVV
HHHCCCCCCHHHHHH		34.8722468782
143PhosphorylationKLLDPEPSFLKECRR
CCCCCCCHHHHHHHH		41.3624719451
197PhosphorylationKGQGQGESLRVKKKA
CCCCCCCCHHHHHHH		28.4425056879
230PhosphorylationKEKAILISDDDEQRT
EEEEEEECCCCHHCC		31.3824043423
237PhosphorylationSDDDEQRTFQDEYEI
CCCCHHCCCCCHHHH		25.9124043423
242PhosphorylationQRTFQDEYEISEMVG
HCCCCCHHHHHHHHH		27.1824043423
245PhosphorylationFQDEYEISEMVGYCA
CCCHHHHHHHHHHHH		14.0124043423
250PhosphorylationEISEMVGYCAARSEG
HHHHHHHHHHHHCCC		2.7824043423
268PhosphorylationSFHTISPTLFNASSN
CCCCCCCCCCCCCCC		36.8724719451
297PhosphorylationLSGHLPKYEQVHILP
HCCCCCCCCEEEEEC		15.0627642862
343PhosphorylationDVQDVMFYSILAMLR
HHHHHHHHHHHHHHH		4.08-
344PhosphorylationVQDVMFYSILAMLRD
HHHHHHHHHHHHHHH		10.40-
407PhosphorylationLEAIMVLSDFQHDLL
HHHHHHHCHHCHHHH		25.6023403867
417PhosphorylationQHDLLACSMEKRILL
CHHHHHHCHHHHHHH		25.1123403867
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GSDMC_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GSDMC_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GSDMC_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of GSDMC_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GSDMC_HUMAN

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Related Literatures of Post-Translational Modification

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