GRPE1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GRPE1_RAT
• UniProt AC: P97576
• Protein Name: GrpE protein homolog 1, mitochondrial
• Gene Name: Grpel1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 217
• Subcellular Localization: Mitochondrion matrix.
• Protein Description: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins..
• Protein Sequence: MAARCVRLARRSLPALALSFRPSPRLLCTATKQKNNGQNLEEDLGHCEPKTDPSSADKTLLEEKVKLEEQLKETMEKYKRALADTENLRQRSQKLVEEAKLYGIQGFCKDLLEVADILEKATQSVPKEEVSNNNPHLKSLYEGLVMTEVQIQKVFTKHGLLRLDPIGAKFDPYEHEALFHTPVEGKEPGTVALVSKVGYKLHGRTLRPALVGVVKDA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
64	Acetylation	DKTLLEEKVKLEEQL CHHHHHHHHHHHHHH	34.98	22902405
66	Acetylation	TLLEEKVKLEEQLKE HHHHHHHHHHHHHHH	62.34	22902405
72	Acetylation	VKLEEQLKETMEKYK HHHHHHHHHHHHHHH	51.32	22902405
77	Acetylation	QLKETMEKYKRALAD HHHHHHHHHHHHHHC	45.29	22902405
94	Acetylation	NLRQRSQKLVEEAKL HHHHHHHHHHHHHHH	56.60	22902405
94	Succinylation	NLRQRSQKLVEEAKL HHHHHHHHHHHHHHH	56.60	-
94	Succinylation	NLRQRSQKLVEEAKL HHHHHHHHHHHHHHH	56.60	-
100	Acetylation	QKLVEEAKLYGIQGF HHHHHHHHHHCCHHH	45.59	-
120	Succinylation	EVADILEKATQSVPK HHHHHHHHHHCCCCH	53.97	-
120	Succinylation	EVADILEKATQSVPK HHHHHHHHHHCCCCH	53.97	-
157	Acetylation	QIQKVFTKHGLLRLD HHHHHHHHCCCEEEC	24.98	22902405
186	Acetylation	FHTPVEGKEPGTVAL CCCCCCCCCCCCEEE	47.43	22902405
215	Acetylation	PALVGVVKDA----- HHHHEEECCC-----	45.60	22902405
215	Succinylation	PALVGVVKDA----- HHHHEEECCC-----	45.60	-
215	Succinylation	PALVGVVKDA----- HHHHEEECCC-----	45.60	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GRPE1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GRPE1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GRPE1_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.