GRM6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GRM6_HUMAN
• UniProt AC: O15303
• Protein Name: Metabotropic glutamate receptor 6
• Gene Name: GRM6
• Organism: Homo sapiens (Human).
• Sequence Length: 877
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein . Cell projection, dendrite. Subject to trafficking from the endoplasmic reticulum to
• Protein Description: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision..
• Protein Sequence: MARPRRAREPLLVALLPLAWLAQAGLARAAGSVRLAGGLTLGGLFPVHARGAAGRACGQLKKEQGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGRGDGDEVGVRCPGGVPPLRPAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSIKIPREPKPGEFSKVIRRLMETPNARGIIIFANEDDIRRVLEAARQANLTGHFLWVGSDSWGAKTSPILSLEDVAVGAITILPKRASIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCKLTSSGTQSDDSTRKCTGEERIGRDSTYEQEGKVQFVIDAVYAIAHALHSMHQALCPGHTGLCPAMEPTDGRMLLQYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNGSASSGGYQAVGQWAETLRLDVEALQWSGDPHEVPSSLCSLPCGPGERKKMVKGVPCCWHCEACDGYRFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLSWSSPWAAPPLLLAVLGIVATTTVVATFVRYNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPGAAVCAARRLFLGLGTTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFSLTSLQVVGMIAWLGARPPHSVIDYEEQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQNVQKRKRSLKATSTVAAPPKGEDAEAHK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
32	Phosphorylation	GLARAAGSVRLAGGL HHHHHCCCEEECCCE	10.19	-
40	Phosphorylation	VRLAGGLTLGGLFPV EEECCCEEECCCCCH	26.99	-
296	N-linked_Glycosylation	LEAARQANLTGHFLW HHHHHHCCCCCCEEE	29.78	UniProtKB CARBOHYD
371	Phosphorylation	NFNCKLTSSGTQSDD HCCCEEECCCCCCCC	36.89	-
451	N-linked_Glycosylation	YIRAVRFNGSAGTPV HHHHHEECCCCCCCE	32.71	UniProtKB CARBOHYD
479	N-linked_Glycosylation	IFQYQATNGSASSGG EEEEEECCCCCCCCC	45.50	UniProtKB CARBOHYD
567	N-linked_Glycosylation	GDMRPTPNHTGCRPT CCCCCCCCCCCCCCC	48.07	UniProtKB CARBOHYD
582	Phosphorylation	PVVRLSWSSPWAAPP CEEEEECCCCCCCHH	24.13	24248375
583	Phosphorylation	VVRLSWSSPWAAPPL EEEEECCCCCCCHHH	20.43	24248375
600	Phosphorylation	AVLGIVATTTVVATF HHHHHHHHHHHHHHH	16.47	24248375
601	Phosphorylation	VLGIVATTTVVATFV HHHHHHHHHHHHHHH	14.09	24248375
602	Phosphorylation	LGIVATTTVVATFVR HHHHHHHHHHHHHHC	14.50	24248375
610	Phosphorylation	VVATFVRYNNTPIVR HHHHHHCCCCCCEEE	13.89	24248375
664	Phosphorylation	LGLGTTLSYSALLTK HCCCCCCCHHHHHHH	18.23	24719451
670	Phosphorylation	LSYSALLTKTNRIYR CCHHHHHHHCCHHHH	36.35	-
672	Phosphorylation	YSALLTKTNRIYRIF HHHHHHHCCHHHHHH	25.21	-
676	Phosphorylation	LTKTNRIYRIFEQGK HHHCCHHHHHHHCCC	8.40	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GRM6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GRM6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GRM6_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of GRM6_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.