GRM4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GRM4_MOUSE
• UniProt AC: Q68EF4
• Protein Name: Metabotropic glutamate receptor 4
• Gene Name: Grm4
• Organism: Mus musculus (Mouse).
• Sequence Length: 912
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity (By similarity)..
• Protein Sequence: MSGKGGWAWWWARLPLCLLLSLYGSWVPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGRGSEGKACGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSLTFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTLASEGSYGESGVEAFIQKSRENGGVCIAQSVKIPREPKTGEFDKIIKRLLETSNARAIIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKSAPVLRLEEVAEGAVTILPKRTSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKLSRHALKKGSHIKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQRRNGSAEYKVIGSWTDHLHLRIERMQWPGSGQQLPRSICSLPCQPGERKKTVKGMACCWHCEPCTGYQYQVDRYTCKTCPYDMRPTENRTSCQPIPIVKLEWDSPWAVLPLFLAVVGIAATLFVVVTFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFVLISLQLLCICVWFVVDPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLEAPALATKQTYVTYTNHAI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
98	N-linked_Glycosylation	NDPDLLPNITLGARI CCCCCCCCCCHHHHH	39.59	-
220	Phosphorylation	VRALKWNYVSTLASE HHHHCCCCHHCCCCC	8.48	21082442
229	Phosphorylation	STLASEGSYGESGVE HCCCCCCCCCCHHHH	26.39	21082442
230	Phosphorylation	TLASEGSYGESGVEA CCCCCCCCCCHHHHH	35.45	21082442
301	N-linked_Glycosylation	LEAARRANQTGHFFW HHHHHHHHCCCCEEE	37.83	-
347	Phosphorylation	SVRGFDRYFSSRTLD CCCCCCCEEECCCCC	15.06	29895711
349	Phosphorylation	RGFDRYFSSRTLDNN CCCCCEEECCCCCCC	15.24	29895711
414	Phosphorylation	QFVIDAVYAMGHALH CHHHHHHHHHHHHHH	7.81	29899451
615	Phosphorylation	TFVRYNDTPIVKASG HHHCCCCCCCEECCC	15.98	28059163
689	Phosphorylation	EQGKRSVSAPRFISP HCCCCCCCCCCCCCH	33.53	22942356
770	Phosphorylation	LMVTCTVYAIKTRGV HHHHHHHHHHHCCCC	5.62	25177544
870	Phosphorylation	VVTAATMSNKFTQKG HHHHHHHCCCCCCCC	32.30	29899451
872	Ubiquitination	TAATMSNKFTQKGNF HHHHHCCCCCCCCCC	42.34	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GRM4_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GRM4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GRM4_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.