GRM4_HUMAN - dbPTM
GRM4_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GRM4_HUMAN
UniProt AC Q14833
Protein Name Metabotropic glutamate receptor 4
Gene Name GRM4
Organism Homo sapiens (Human).
Sequence Length 912
Subcellular Localization Cell membrane
Multi-pass membrane protein .
Protein Description G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity..
Protein Sequence MPGKRGLGWWWARLPLCLLLSLYGPWMPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGRGSEGKPCGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSLTFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLETSNARAVIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKIAPVLHLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKLSRHALKKGSHVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNDSAEYKVIGSWTDHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCWHCEPCTGYQYQVDRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIAATLFVVITFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQLLGICVWFVVDPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLEAPALATKQTYVTYTNHAI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
98N-linked_GlycosylationNDPDLLPNITLGARI
CCCCCCCCCCHHHHH		39.59UniProtKB CARBOHYD
138PhosphorylationGTEVRCGSGGPPIIT
CCEEECCCCCCCCCC		44.1730576142
145PhosphorylationSGGPPIITKPERVVG
CCCCCCCCCCCEEEE		41.0730576142
301N-linked_GlycosylationLEAARRANQTGHFFW
HHHHHHHHCCCCEEE		37.83UniProtKB CARBOHYD
311PhosphorylationGHFFWMGSDSWGSKI
CCEEEECCCCCCCCE		16.6222210691
333PhosphorylationEVAEGAVTILPKRMS
HHHCCCEEEECCCCC		19.0922210691
414PhosphorylationQFVIDAVYAMGHALH
CHHHHHHHHHHHHHH		7.81-
454N-linked_GlycosylationLKYIRNVNFSGIAGN
HHHHHCCCCCCCCCC		28.99UniProtKB CARBOHYD
484N-linked_GlycosylationIYQYQLRNDSAEYKV
EEEEEECCCCCCEEE		57.06UniProtKB CARBOHYD
555PhosphorylationYQYQVDRYTCKTCPY
CEEEEEEEECCCCCC		16.42-
562PhosphorylationYTCKTCPYDMRPTEN
EECCCCCCCCCCCCC		25.23-
569N-linked_GlycosylationYDMRPTENRTGCRPI
CCCCCCCCCCCCEEE		49.66UniProtKB CARBOHYD
612PhosphorylationVVITFVRYNDTPIVK
HHHHHHCCCCCCCEE		16.4623312004
615PhosphorylationTFVRYNDTPIVKASG
HHHCCCCCCCEECCC		15.9823312004
672PhosphorylationISYAALLTKTNRIYR
HHHHHHHHHCCHHHH		36.3518491316
674PhosphorylationYAALLTKTNRIYRIF
HHHHHHHCCHHHHHH		25.2118491316
678PhosphorylationLTKTNRIYRIFEQGK
HHHCCHHHHHHHCCC		8.40-
695PhosphorylationVSAPRFISPASQLAI
CCCCCCCCHHHHHHH		16.2324043423
698PhosphorylationPRFISPASQLAITFS
CCCCCHHHHHHHHHH		29.1624043423
703PhosphorylationPASQLAITFSLISLQ
HHHHHHHHHHHHHHH		11.1024043423
705PhosphorylationSQLAITFSLISLQLL
HHHHHHHHHHHHHHH		19.0224043423
708PhosphorylationAITFSLISLQLLGIC
HHHHHHHHHHHHCCE		18.5024043423
723PhosphorylationVWFVVDPSHSVVDFQ
EEEECCCCCCCCCCC		24.7524043423
725PhosphorylationFVVDPSHSVVDFQDQ
EECCCCCCCCCCCCC		28.3324043423
816PhosphorylationSQSADKLYIQTTTLT
CCCCCEEEEEEEEEE		9.2024043423
819PhosphorylationADKLYIQTTTLTVSV
CCEEEEEEEEEEEEE		16.5224043423
820PhosphorylationDKLYIQTTTLTVSVS
CEEEEEEEEEEEEEE		11.9324043423
821PhosphorylationKLYIQTTTLTVSVSL
EEEEEEEEEEEEEEE		24.6624043423
823PhosphorylationYIQTTTLTVSVSLSA
EEEEEEEEEEEEECE		14.5124043423
825PhosphorylationQTTTLTVSVSLSASV
EEEEEEEEEEECEEE		10.7624043423
827PhosphorylationTTLTVSVSLSASVSL
EEEEEEEEECEEEEC		14.7524043423
829PhosphorylationLTVSVSLSASVSLGM
EEEEEEECEEEECCC		15.8124043423
831PhosphorylationVSVSLSASVSLGMLY
EEEEECEEEECCCEE		14.6324043423
833PhosphorylationVSLSASVSLGMLYMP
EEECEEEECCCEECC		19.4024043423
838PhosphorylationSVSLGMLYMPKVYII
EEECCCEECCEEEEE		11.5024043423
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GRM4_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GRM4_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GRM4_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of GRM4_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GRM4_HUMAN

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Related Literatures of Post-Translational Modification

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