GRIK4_HUMAN - dbPTM
GRIK4_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GRIK4_HUMAN
UniProt AC Q16099
Protein Name Glutamate receptor ionotropic, kainate 4
Gene Name GRIK4
Organism Homo sapiens (Human).
Sequence Length 956
Subcellular Localization Cell membrane
Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane
Multi-pass membrane protein.
Protein Description Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists..
Protein Sequence MPRVSAPLVLLPAWLVMVACSPHSLRIAAILDDPMECSRGERLSITLAKNRINRAPERLGKAKVEVDIFELLRDSEYETAETMCQILPKGVVAVLGPSSSPASSSIISNICGEKEVPHFKVAPEEFVKFQFQRFTTLNLHPSNTDISVAVAGILNFFNCTTACLICAKAECLLNLEKLLRQFLISKDTLSVRMLDDTRDPTPLLKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAYYTYIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHAFFQEFAQSLNQSWQENCDHVPFTGPALSSALLFDAVYAVVTAVQELNRSQEIGVKPLSCGSAQIWQHGTSLMNYLRMVELEGLTGHIEFNSKGQRSNYALKILQFTRNGFRQIGQWHVAEGLSMDSHLYASNISDTLFNTTLVVTTILENPYLMLKGNHQEMEGNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYGVPEANGTWTGMVGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLADQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNSNYAFLLESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILKRKWWEGGKCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFLWTLRHSEATEVSVCQEMVTELRSIILCQDSIHPRRRRAAVPPPRPPIPEERRPRGTATLSNGKLCGAGEPDQLAQRLAQEAALVARGCTHIRVCPECRRFQGLRARPSPARSEESLEWEKTTNSSEPE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
158N-linked_GlycosylationAGILNFFNCTTACLI
HHHHHHCCCHHHHHH		20.35UniProtKB CARBOHYD
177SumoylationECLLNLEKLLRQFLI
HHHHCHHHHHHHHHH		56.86-
177SumoylationECLLNLEKLLRQFLI
HHHHCHHHHHHHHHH		56.86-
201PhosphorylationLDDTRDPTPLLKEIR
CCCCCCCCHHHHHHC		30.7524719451
220N-linked_GlycosylationATIIIHANASMSHTI
EEEEEECCCCCCHHH		20.56UniProtKB CARBOHYD
272N-linked_GlycosylationILGFSIFNQSHAFFQ
ECCHHHCCCHHHHHH		40.55UniProtKB CARBOHYD
286N-linked_GlycosylationQEFAQSLNQSWQENC
HHHHHHHHHHHHHCC		38.80UniProtKB CARBOHYD
323N-linked_GlycosylationVTAVQELNRSQEIGV
HHHHHHHHHCCCCCC		40.58UniProtKB CARBOHYD
325PhosphorylationAVQELNRSQEIGVKP
HHHHHHHCCCCCCEE		30.96-
334PhosphorylationEIGVKPLSCGSAQIW
CCCCEECCCCCHHHH		25.5920363803
346PhosphorylationQIWQHGTSLMNYLRM
HHHHCHHHHHHHHHH		30.1620363803
350PhosphorylationHGTSLMNYLRMVELE
CHHHHHHHHHHHHHC		5.0220363803
360PhosphorylationMVELEGLTGHIEFNS
HHHHCCCCEEEEECC		37.2630257219
367PhosphorylationTGHIEFNSKGQRSNY
CEEEEECCCCCCCCH		43.4130257219
408N-linked_GlycosylationDSHLYASNISDTLFN
CCCEECCCCCHHHCC		29.61UniProtKB CARBOHYD
415N-linked_GlycosylationNISDTLFNTTLVVTT
CCCHHHCCCEEEEEE		34.95UniProtKB CARBOHYD
479N-linked_GlycosylationVYGVPEANGTWTGMV
CCCCCCCCCCEEHHH		46.92UniProtKB CARBOHYD
609PhosphorylationGGFMQQGSTIAPRAL
CHHHCCCCCCCCHHH		16.59-
610PhosphorylationGFMQQGSTIAPRALS
HHHCCCCCCCCHHHH		28.16-
645PhosphorylationANLAAFLTVQRMDVP
CHHHHHHHHHCCCCC		14.2424719451
696PhosphorylationRMWNYMYSKQPSVFV
HHHHHHHCCCCCEEE		14.3224719451
736N-linked_GlycosylationYYRQRNCNLTQIGGL
HHHHCCCCCCCCCCC		50.07-
757PhosphorylationGIGMPVGSVFRDEFD
CCCCCCCHHHHCCHH		20.5122210691
858PhosphorylationSIILCQDSIHPRRRR
HHHHCCCCCCCCHHC		9.2724732914
936PhosphorylationQGLRARPSPARSEES
CCCCCCCCCCCCHHH		26.1618510355
943PhosphorylationSPARSEESLEWEKTT
CCCCCHHHHCCHHCC		27.7718510355
949PhosphorylationESLEWEKTTNSSEPE
HHHCCHHCCCCCCCC		21.5016674116
953PhosphorylationWEKTTNSSEPE----
CHHCCCCCCCC----		60.2816674116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GRIK4_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GRIK4_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GRIK4_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of GRIK4_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D00537 Topiramate (JAN/USAN/INN); Topamax (TN); Trokendi xr (TN)
D02546 Kainic acid hydrate (JP16); Digenin (TN)
D06656 Tezampanel (USAN); Tezampanel hydrate
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GRIK4_HUMAN

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Related Literatures of Post-Translational Modification

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