dbPTM

GRCR1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GRCR1_HUMAN
UniProt AC	A8MXD5
Protein Name	Glutaredoxin domain-containing cysteine-rich protein 1
Gene Name	GRXCR1
Organism	Homo sapiens (Human).
Sequence Length	290
Subcellular Localization	Cell projection, stereocilium. Cell projection, microvillus. Cell projection, kinocilium. In the inner ear, localized to stereocilia, apical microvilli of sensory cells and kinocilia..
Protein Description	May play a role in actin filament architecture in developing stereocilia of sensory cells..
Protein Sequence	MLKREMKPESDRPRKVRFRIASSHSGRVLKEVYEDGQPSGSLDSECASICGIDGLGDSDGQQNGHIESEGDENENDQDSLLVLARAASEKGFGTRRVNILSKNGTVRGVKYKVSAGQALFNNLTKVLQQPSTDLEFDRVVIYTTCLRVVRTTFERCELVRKIFQNHRVKFEEKNIALNGEYGKELDERCRRVSEAPSLPVVFIDGHYLGGAEKILSMNESGELQDILTKIERVQHPHECPSCGGFGFLPCSVCHGSKMSMFRNCFTDSFKALKCTACNENGLQRCKNCAG

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	Phosphorylation	KVRFRIASSHSGRVL CEEEEEEECCCCCEE	26.64	18785766
111	Phosphorylation	GTVRGVKYKVSAGQA CCCCCEEEEEEHHHH	17.76	-
125	Ubiquitination	ALFNNLTKVLQQPST HHHHHHHHHHHCCCC	44.08	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of GRCR1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GRCR1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GRCR1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of GRCR1_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
613285	Deafness, autosomal recessive, 25 (DFNB25)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GRCR1_HUMAN

Related Literatures of Post-Translational Modification