GRB14_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GRB14_RAT
• UniProt AC: O88900
• Protein Name: Growth factor receptor-bound protein 14
• Gene Name: Grb14
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 538
• Subcellular Localization: Cytoplasm . Endosome membrane ; Peripheral membrane protein . Upon insulin stimulation, translocates to the plasma membrane.
• Protein Description: Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal (By similarity)..
• Protein Sequence: MTTSLQDGQSAAGRAGAQDSPLAVQVCRVAQGKGDAQDPAQVPGLHALSPASDATRRGAMDRRKAKDLEVQETPSIPNPFPELCCSPLTSVLSAGLFPRSNSRKKQVIKVYSEDETSRALEVPSDVTARDVCQLLILKNHYVDDNSWTLFEHLSHTGVERTVEDHELLTEVLSHWVMEEDNKLYLRKNYAKYEFFKNPMYFFPEHMVSFATEMNGDRSLTQIPQVFLSSNTYPEIHGFLHAKEQGKKSWKKAYFFLRRSGLYFSTKGTSKEPRHLQFFSEFSTSNVYMSLAGKKKHGAPTPYGFCFKPTKAGGPRDLKMLCAEEDQSRMCWVTAIRLLKYGMQLYQNYMHPSQARSACSSQSVSPMRSVSENSLVAMDFSGQKTRVIDNPTEALSVAVEEGLAWRKKGCLRLGNHGSPTAPSQSSAVNMALHRSQPWFHHRISRDEAQQLITRQGPVDGVFLVRDSQSNPRTFVLSMSHGQKIKHFQIIPVEDDGEVFHTLDDGHTKFTDLIQLVEFYQLNKGVLPCKLKHYCARMAV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MTTSLQDGQ ------CCCCCCCCC	25.70	-
20	Phosphorylation	GRAGAQDSPLAVQVC CCCCCCCCCCHHHHH	15.10	23984901
49	Phosphorylation	VPGLHALSPASDATR CCCCEECCCCCHHHH	21.14	25575281
52	Phosphorylation	LHALSPASDATRRGA CEECCCCCHHHHCCC	31.03	25575281
55	Phosphorylation	LSPASDATRRGAMDR CCCCCHHHHCCCCHH	26.37	25575281
345	Phosphorylation	LKYGMQLYQNYMHPS HHHHHHHHHHCCCHH	4.28	21791607
360	Phosphorylation	QARSACSSQSVSPMR HHHHHHHCCCCCCCC	26.76	23984901
362	Phosphorylation	RSACSSQSVSPMRSV HHHHHCCCCCCCCCC	26.89	23984901
364	Phosphorylation	ACSSQSVSPMRSVSE HHHCCCCCCCCCCCC	20.44	23984901
368	Phosphorylation	QSVSPMRSVSENSLV CCCCCCCCCCCCCEE	24.60	21738781
370	Phosphorylation	VSPMRSVSENSLVAM CCCCCCCCCCCEEEE	32.10	29779826
373	Phosphorylation	MRSVSENSLVAMDFS CCCCCCCCEEEEECC	21.85	29779826
380	Phosphorylation	SLVAMDFSGQKTRVI CEEEEECCCCEEEEE	35.73	28689409
417	Phosphorylation	LRLGNHGSPTAPSQS EECCCCCCCCCCCHH	16.13	21738781
419	Phosphorylation	LGNHGSPTAPSQSSA CCCCCCCCCCCHHHH	53.55	21738781
422	Phosphorylation	HGSPTAPSQSSAVNM CCCCCCCCHHHHHHH	39.98	23984901
424	Phosphorylation	SPTAPSQSSAVNMAL CCCCCCHHHHHHHHH	25.30	23984901
425	Phosphorylation	PTAPSQSSAVNMALH CCCCCHHHHHHHHHH	28.71	23984901

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GRB14_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GRB14_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GRB14_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of GRB14_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.