GRAP1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GRAP1_RAT
• UniProt AC: Q9JHZ4
• Protein Name: GRIP1-associated protein 1
• Gene Name: Gripap1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 837
• Subcellular Localization: Early endosome membrane ; Peripheral membrane protein . Recycling endosome membrane ; Peripheral membrane protein . Cell projection, axon . Cell projection, dendrite . Cell junction, synapse . Localizes to recycling endosomal tubules that are emanati
• Protein Description: Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity-induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity.; GRASP-1 C-terminal chain: Functions as a scaffold protein in neurons to facilitate MAP3K1/MEKK1-mediated activation of the JNK1 kinase by phosphorylation, possibly by bringing MAP3K1/MEKK1 and JNK1 in close proximity..
• Protein Sequence: MAQALSEEEFQRMQTQLLELRTNNYQLSDELRKNGVELSSLRQKVAYLDKEFSKAQKALSKSKKAQEVEVLLSEKEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQLEQLELENRQLKEGVPGAAGPHVDGELLRLQAENTALQKNMAALQERYGKEAVRPSAVSEGQGDPPGDVLPISLSPMPLAEVELKWEMEREEKKLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADLKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSSQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQNTELAAELKHRQADYEELMGQKDDLNSQLQESLRANSRLLEQLQEMGQEKEQLIQDLQEARKSAEKRKVMLDELAMETLQEKSQHKEELGAVRLRHEKEMLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELENLQHTVEELQAQVHSMDGAKGWFERRLKEAEESLLQQEQEQEETLKQCREQHAAELKGKEEELQNVRDQLQQAQEERDGHVKTISNLKQEVKDTVDGQRILEKKGSAVLKDLKRQLHLERKRADKLQERLQEILTNSKSRTGLEELVLSEMNSPSRTQTGDSSSVSSFSYREILKEKESSAIPARSLSSSPQAQPPRPAELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSSASMAEDLCRKSAIIETYVMDSRIDVSVAAGHTDRSGLGSVLRDLVKPGDENLREMNKKLQNMLEEQLTKNMHLHKDMEVLSQEIVRLSKECVGSPDPDLEPGEAN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAQALSEEE ------CCCCCCHHH	11.89	-
40	Phosphorylation	KNGVELSSLRQKVAY HCCCCHHHHHHHHHH	39.95	21630457
179	Phosphorylation	PGDVLPISLSPMPLA CCCEEEEECCCCCCH	22.36	28432305
181	Phosphorylation	DVLPISLSPMPLAEV CEEEEECCCCCCHHC	16.62	22108457
228	Phosphorylation	QEELAKLSEKLKKKQ HHHHHHHHHHHHHHH	31.79	30181290
367	Ubiquitination	TELAAELKHRQADYE HHHHHHHHHHHHCHH	28.39	-
647	Phosphorylation	GLEELVLSEMNSPSR CHHHHHHHCCCCCCC	27.59	28551015
651	Phosphorylation	LVLSEMNSPSRTQTG HHHHCCCCCCCCCCC	23.96	27097102
653	Phosphorylation	LSEMNSPSRTQTGDS HHCCCCCCCCCCCCC	48.02	27097102
655	Phosphorylation	EMNSPSRTQTGDSSS CCCCCCCCCCCCCCC	34.52	22673903
657	Phosphorylation	NSPSRTQTGDSSSVS CCCCCCCCCCCCCCC	42.20	28432305
660	Phosphorylation	SRTQTGDSSSVSSFS CCCCCCCCCCCCCCC	26.34	28432305
661	Phosphorylation	RTQTGDSSSVSSFSY CCCCCCCCCCCCCCH	39.23	28432305
662	Phosphorylation	TQTGDSSSVSSFSYR CCCCCCCCCCCCCHH	29.94	28432305
664	Phosphorylation	TGDSSSVSSFSYREI CCCCCCCCCCCHHHH	27.84	28432305
665	Phosphorylation	GDSSSVSSFSYREIL CCCCCCCCCCHHHHH	18.96	28432305
667	Phosphorylation	SSSVSSFSYREILKE CCCCCCCCHHHHHHH	25.81	28432305
668	Phosphorylation	SSVSSFSYREILKEK CCCCCCCHHHHHHHH	15.39	25575281
675	Ubiquitination	YREILKEKESSAIPA HHHHHHHHHCCCCCC	62.40	-
677	Phosphorylation	EILKEKESSAIPARS HHHHHHHCCCCCCCC	35.82	28689409
684	Phosphorylation	SSAIPARSLSSSPQA CCCCCCCCCCCCCCC	34.41	27097102
686	Phosphorylation	AIPARSLSSSPQAQP CCCCCCCCCCCCCCC	29.98	27097102
687	Phosphorylation	IPARSLSSSPQAQPP CCCCCCCCCCCCCCC	51.86	27097102
688	Phosphorylation	PARSLSSSPQAQPPR CCCCCCCCCCCCCCC	20.04	23712012
700	Phosphorylation	PPRPAELSDEEVAEL CCCCCCCCHHHHHHH	34.19	27097102
742	Ubiquitination	MAEDLCRKSAIIETY HHHHHHHCCHHHHHH	43.15	-
813	Phosphorylation	HKDMEVLSQEIVRLS HHCHHHHHHHHHHHH	30.83	-
826	Phosphorylation	LSKECVGSPDPDLEP HHHHHHCCCCCCCCC	13.01	28551015

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GRAP1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GRAP1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GRAP1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of GRAP1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.