dbPTM

GPX1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GPX1_MOUSE
UniProt AC	P11352
Protein Name	Glutathione peroxidase 1
Gene Name	Gpx1
Organism	Mus musculus (Mouse).
Sequence Length	201
Subcellular Localization	Cytoplasm.
Protein Description	Protects the hemoglobin in erythrocytes from oxidative breakdown..
Protein Sequence	MCAARLSAAAQSTVYAFSARPLTGGEPVSLGSLRGKVLLIENVASLUGTTIRDYTEMNDLQKRLGPRGLVVLGFPCNQFGHQENGKNEEILNSLKYVRPGGGFEPNFTLFEKCEVNGEKAHPLFTFLRNALPTPSDDPTALMTDPKYIIWSPVCRNDIAWNFEKFLVGPDGVPVRRYSRRFRTIDIEPDIETLLSQQSGNS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MCAARLSAAAQSTV -CCHHHHHHHHHCCE	15.42	26824392
12	Phosphorylation	RLSAAAQSTVYAFSA HHHHHHHCCEEEEEC	18.34	-
23	Phosphorylation	AFSARPLTGGEPVSL EEECCCCCCCCCCCC	45.91	21082442
29	Phosphorylation	LTGGEPVSLGSLRGK CCCCCCCCCCHHCCE	37.41	22817900
32	Phosphorylation	GEPVSLGSLRGKVLL CCCCCCCHHCCEEEE	21.86	22324799
62	Malonylation	TEMNDLQKRLGPRGL HHHHHHHHHHCCCCE	57.81	26320211
62	Succinylation	TEMNDLQKRLGPRGL HHHHHHHHHHCCCCE	57.81	23806337
62	Glutarylation	TEMNDLQKRLGPRGL HHHHHHHHHHCCCCE	57.81	24703693
62	Acetylation	TEMNDLQKRLGPRGL HHHHHHHHHHCCCCE	57.81	23576753
62	Succinylation	TEMNDLQKRLGPRGL HHHHHHHHHHCCCCE	57.81	-
62	Ubiquitination	TEMNDLQKRLGPRGL HHHHHHHHHHCCCCE	57.81	-
76	S-palmitoylation	LVVLGFPCNQFGHQE EEEEECCHHHCCCCC	6.12	28526873
86	Ubiquitination	FGHQENGKNEEILNS CCCCCCCCCHHHHHH	73.16	-
86	Succinylation	FGHQENGKNEEILNS CCCCCCCCCHHHHHH	73.16	23806337
86	Malonylation	FGHQENGKNEEILNS CCCCCCCCCHHHHHH	73.16	26320211
86	Acetylation	FGHQENGKNEEILNS CCCCCCCCCHHHHHH	73.16	23576753
86	Succinylation	FGHQENGKNEEILNS CCCCCCCCCHHHHHH	73.16	-
93	Phosphorylation	KNEEILNSLKYVRPG CCHHHHHHCCEECCC	23.85	20469934
95	Succinylation	EEILNSLKYVRPGGG HHHHHHCCEECCCCC	41.33	23806337
95	Acetylation	EEILNSLKYVRPGGG HHHHHHCCEECCCCC	41.33	23864654
96	Phosphorylation	EILNSLKYVRPGGGF HHHHHCCEECCCCCC	13.64	23984901
112	Succinylation	PNFTLFEKCEVNGEK CCEEEEEEEEECCEE	28.50	-
112	Acetylation	PNFTLFEKCEVNGEK CCEEEEEEEEECCEE	28.50	23576753
112	Succinylation	PNFTLFEKCEVNGEK CCEEEEEEEEECCEE	28.50	23806337
112	Malonylation	PNFTLFEKCEVNGEK CCEEEEEEEEECCEE	28.50	26320211
119	Acetylation	KCEVNGEKAHPLFTF EEEECCEECCHHHHH	54.09	23576753
119	Ubiquitination	KCEVNGEKAHPLFTF EEEECCEECCHHHHH	54.09	-
119	Malonylation	KCEVNGEKAHPLFTF EEEECCEECCHHHHH	54.09	26320211
135	Phosphorylation	RNALPTPSDDPTALM HHCCCCCCCCCCCCC	58.06	23984901
139	Phosphorylation	PTPSDDPTALMTDPK CCCCCCCCCCCCCCC	39.14	29472430
143	Phosphorylation	DDPTALMTDPKYIIW CCCCCCCCCCCEEEE	50.42	25195567
146	Succinylation	TALMTDPKYIIWSPV CCCCCCCCEEEECCC	52.47	-
146	Malonylation	TALMTDPKYIIWSPV CCCCCCCCEEEECCC	52.47	26073543
146	Succinylation	TALMTDPKYIIWSPV CCCCCCCCEEEECCC	52.47	23806337
146	Ubiquitination	TALMTDPKYIIWSPV CCCCCCCCEEEECCC	52.47	-
146	Acetylation	TALMTDPKYIIWSPV CCCCCCCCEEEECCC	52.47	23576753
147	Phosphorylation	ALMTDPKYIIWSPVC CCCCCCCEEEECCCC	11.74	25521595
151	Phosphorylation	DPKYIIWSPVCRNDI CCCEEEECCCCCCCC	9.31	22942356
154	S-palmitoylation	YIIWSPVCRNDIAWN EEEECCCCCCCCCCC	3.70	28526873
164	Acetylation	DIAWNFEKFLVGPDG CCCCCHHHHCCCCCC	39.60	23954790
195	Phosphorylation	PDIETLLSQQSGNS- CCHHHHHHHCCCCC-	29.32	23984901
198	Phosphorylation	ETLLSQQSGNS---- HHHHHHCCCCC----	32.10	22324799
201	Phosphorylation	LSQQSGNS------- HHHCCCCC-------	45.16	17203969

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of GPX1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GPX1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GPX1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of GPX1_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GPX1_MOUSE

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Substrate and functional diversity of lysine acetylation revealed bya proteomics survey."; Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T.,Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y.; Mol. Cell 23:607-618(2006). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-146, AND MASS SPECTROMETRY.	16916647 [Abstract]
Phosphorylation
Reference	PubMed
"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry."; Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.; J. Proteome Res. 6:250-262(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-201, AND MASSSPECTROMETRY.	17203969 [Abstract]