GPTC8_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GPTC8_MOUSE
• UniProt AC: A2A6A1
• Protein Name: G patch domain-containing protein 8
• Gene Name: Gpatch8
• Organism: Mus musculus (Mouse).
• Sequence Length: 1505
• Protein Sequence: MADRFSRFNEDRDFQGNHFDQYEEGHLEIEQASLDKPIESDNIGHRLLQKHGWKLGQGLGKSLQGRTDPIPIVVKYDVMGMGRMEMELDYAEDATERRRVLEVEKEDTEELRQKYKDYVDKEKAIAKALEDLRANFYCELCDKQYQKHQEFDNHINSYDHAHKQRLKDLKQREFARNVSSRSRKDEKKQEKALRRLHELAEQRKQAECAPGSGPMFRPTTVAVDEDGGEEDKDESSTNSGASAVSSCGFGADFSTDKGGSFTSVQITNTTGLSQAPGLASQGISFGIKNNLGPPLQKLGVSFSFAKKAPVKLESIASVFKDHAEEGSSEDGTKADEKSSDQGVQKVGDTDGTGNLDGKKEDEDPQDGGSLASTLSKLKRMKREEGTGATEPEYYHYIPPAHCKVKPNFPFLLFMRASEQMEGDHSAHSKSAPENRKSSSPKPQGCSKTAASPGAERTVSEASELQKEAAVAGPSEPGGKTETKKGSGGGEDEQSVESRETSESPMCESNPKDISQATPATKAGQGPKHPTGPFFPVLSKDESTALQWPSELLIFTKAEPSISYSCNPLYFDFKLSRNKDAKAKGTEKPKDVAGSSKDHLQSLDPREPNKSQEEEQDVVLSSEGRVDEPASGAACSSLNKQEPGGSHMSETEDTGRSHPSKKEPSGKSHRHKKKKKHKKSSKHKRKHKADTEEKSSKAESGEKSKKRKKRKRKKNKSSAAADSERGPKSEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGNSGKKDDGGGGSSCQDHSGRKHKGEPPTSSCQRRANTKHSSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEEEEEEEEEDEDSGSEHSRSRSRSGHRHSSHRSSRRSYSSSSDASSDQSCYSRQHSYSDDSYSDYSDRSRRHSKRSHDSDDSDYTSSKHRSKRHKYSSSDDDYSLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSRSTRSPSQRSGSRKGSWGHESPEERRSGRRDFIRSKIYRSQSPHYFQSGRGEGPGKKEDGRGDDSKGAGLPSQNSNTGTGRGSESDCSPEDKNSVTARLLLEKIQSRKVERKPNVCEEVLATPNKAGLKYKNPPQGYFGPKLPPSLGNKPVLPMIGKLPATRKSNKKCEESGLERGEEQEHSEPEEGSPRSSDAPFGHQFSEEAAGPLSDPPPEEPKSEEATADHSVAPLGTPAHTDCYPGDPAISHNYLPDPSDGDTLESLDSGSQPGPVESSLLPIAPDLEHFPNYAPPSGEPSIESTDGTEDASLAPLESQPITFTPEEMEKYSKLQQAAQQHIQQQLLAKQVKAFPASTALAPATPALQPIHIQQPATASATSITTVQHAILQHHAAAAAAAIGIHPHPHPQPLAQVHHIPQPHLTPISLSHLTHSIIPGHPATFLASHPIHIIPASAIHPGPFTFHPVPHAALYPTLLAPRPAAAAATALHLHPLLHPIFSGQDLQHPPSHGT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
262	Phosphorylation	TDKGGSFTSVQITNT CCCCCCEEEEEEECC	29.68	-
263	Phosphorylation	DKGGSFTSVQITNTT CCCCCEEEEEEECCC	15.26	-
301	Phosphorylation	PLQKLGVSFSFAKKA CHHHHCCEEEHHHCC	17.24	27600695
303	Phosphorylation	QKLGVSFSFAKKAPV HHHCCEEEHHHCCCC	19.45	27600695
307	Acetylation	VSFSFAKKAPVKLES CEEEHHHCCCCCHHH	55.27	22826441
311	Acetylation	FAKKAPVKLESIASV HHHCCCCCHHHHHHH	45.54	22826441
327	Phosphorylation	KDHAEEGSSEDGTKA HHHHHCCCCCCCCCC	33.56	23684622
328	Phosphorylation	DHAEEGSSEDGTKAD HHHHCCCCCCCCCCC	51.03	23684622
376	Malonylation	SLASTLSKLKRMKRE HHHHHHHHHHHHHHH	62.23	26320211
378	Malonylation	ASTLSKLKRMKREEG HHHHHHHHHHHHHCC	54.93	26320211
437	Phosphorylation	SAPENRKSSSPKPQG CCCCCCCCCCCCCCC	32.58	25266776
438	Phosphorylation	APENRKSSSPKPQGC CCCCCCCCCCCCCCC	54.41	25266776
439	Phosphorylation	PENRKSSSPKPQGCS CCCCCCCCCCCCCCC	43.99	25266776
448	Phosphorylation	KPQGCSKTAASPGAE CCCCCCCCCCCCCCC	15.91	27087446
451	Phosphorylation	GCSKTAASPGAERTV CCCCCCCCCCCCCCH	22.77	27087446
457	Phosphorylation	ASPGAERTVSEASEL CCCCCCCCHHHHHHH	21.64	23984901
459	Phosphorylation	PGAERTVSEASELQK CCCCCCHHHHHHHHH	27.17	23984901
462	Phosphorylation	ERTVSEASELQKEAA CCCHHHHHHHHHHHH	34.48	23984901
474	Phosphorylation	EAAVAGPSEPGGKTE HHHHCCCCCCCCCCC	56.35	27841257
479	Acetylation	GPSEPGGKTETKKGS CCCCCCCCCCCCCCC	49.45	23806337
486	Phosphorylation	KTETKKGSGGGEDEQ CCCCCCCCCCCCCHH	43.05	27149854
494	Phosphorylation	GGGEDEQSVESRETS CCCCCHHHHHCCCCC	26.29	27149854
500	Phosphorylation	QSVESRETSESPMCE HHHHCCCCCCCCCCC	36.36	25777480
501	Phosphorylation	SVESRETSESPMCES HHHCCCCCCCCCCCC	31.18	25521595
503	Phosphorylation	ESRETSESPMCESNP HCCCCCCCCCCCCCH	20.08	25521595
508	Phosphorylation	SESPMCESNPKDISQ CCCCCCCCCHHCHHH	54.21	25777480
514	Phosphorylation	ESNPKDISQATPATK CCCHHCHHHCCCCCC	24.72	19854140
562	Phosphorylation	TKAEPSISYSCNPLY ECCCCCCEEECCCEE	18.48	-
610	Phosphorylation	DPREPNKSQEEEQDV CCCCCCCCHHHHHCE	49.84	26370283
645	Phosphorylation	NKQEPGGSHMSETED CCCCCCCCCCCCCCC	23.18	23684622
648	Phosphorylation	EPGGSHMSETEDTGR CCCCCCCCCCCCCCC	35.62	25521595
650	Phosphorylation	GGSHMSETEDTGRSH CCCCCCCCCCCCCCC	31.67	25521595
653	Phosphorylation	HMSETEDTGRSHPSK CCCCCCCCCCCCCCC	28.41	25159016
680	Phosphorylation	KKKHKKSSKHKRKHK HHHHHCCHHHHHHHH	47.89	30387612
722	Phosphorylation	KSSAAADSERGPKSE HHHHHHHCCCCCCCC	25.19	27149854
728	Phosphorylation	DSERGPKSEPPGSGS HCCCCCCCCCCCCCC	59.47	28833060
733	Phosphorylation	PKSEPPGSGSPAPPR CCCCCCCCCCCCCCH	41.70	26824392
735	Phosphorylation	SEPPGSGSPAPPRRR CCCCCCCCCCCCHHH	21.42	25521595
753	Phosphorylation	QDDSQRRSLPAEEGN CCHHHHCCCCHHHCC	40.68	26824392
761	Phosphorylation	LPAEEGNSGKKDDGG CCHHHCCCCCCCCCC	63.95	-
806	Phosphorylation	SSRSSHRSQPSSGDE CCCCCCCCCCCCCCC	40.81	21183079
809	Phosphorylation	SSHRSQPSSGDEDSD CCCCCCCCCCCCCCC	39.04	19060867
810	Phosphorylation	SHRSQPSSGDEDSDD CCCCCCCCCCCCCCC	57.87	19060867
815	Phosphorylation	PSSGDEDSDDASSHR CCCCCCCCCCHHHHH	35.03	19060867
819	Phosphorylation	DEDSDDASSHRLHQK CCCCCCHHHHHHHHC	33.40	29550500
820	Phosphorylation	EDSDDASSHRLHQKS CCCCCHHHHHHHHCC	17.85	29550500
909	Phosphorylation	SDRSRRHSKRSHDSD CHHHHHHCCCCCCCC	28.14	29899451
912	Phosphorylation	SRRHSKRSHDSDDSD HHHHCCCCCCCCCCC	35.07	25521595
915	Phosphorylation	HSKRSHDSDDSDYTS HCCCCCCCCCCCCCC	37.58	25521595
918	Phosphorylation	RSHDSDDSDYTSSKH CCCCCCCCCCCCHHH	37.19	27087446
920	Phosphorylation	HDSDDSDYTSSKHRS CCCCCCCCCCHHHHH	16.69	25521595
921	Phosphorylation	DSDDSDYTSSKHRSK CCCCCCCCCHHHHHH	31.36	23684622
922	Phosphorylation	SDDSDYTSSKHRSKR CCCCCCCCHHHHHHC	31.03	23684622
923	Phosphorylation	DDSDYTSSKHRSKRH CCCCCCCHHHHHHCC	25.36	27149854
973	Methylation	SSSCSRSRSKRRSRS CHHHCCCHHHCCCCC	45.12	-
978	Phosphorylation	RSRSKRRSRSTTAHS CCHHHCCCCCCCHHH	34.32	23684622
980	Phosphorylation	RSKRRSRSTTAHSWQ HHHCCCCCCCHHHHH	31.21	25521595
981	Phosphorylation	SKRRSRSTTAHSWQR HHCCCCCCCHHHHHH	27.22	26643407
982	Phosphorylation	KRRSRSTTAHSWQRS HCCCCCCCHHHHHHH	24.50	25266776
985	Phosphorylation	SRSTTAHSWQRSRSY CCCCCHHHHHHHHCC	23.57	23684622
989	Phosphorylation	TAHSWQRSRSYSRDR CHHHHHHHHCCCCCC	15.52	23737553
991	Phosphorylation	HSWQRSRSYSRDRSR HHHHHHHCCCCCCCC	28.80	23737553
992	Phosphorylation	SWQRSRSYSRDRSRS HHHHHHCCCCCCCCC	13.45	20531401
993	Phosphorylation	WQRSRSYSRDRSRST HHHHHCCCCCCCCCC	29.02	27681418
997	Phosphorylation	RSYSRDRSRSTRSPS HCCCCCCCCCCCCCC	34.57	22802335
1002	Phosphorylation	DRSRSTRSPSQRSGS CCCCCCCCCCCCCCC	29.05	23140645
1004	Phosphorylation	SRSTRSPSQRSGSRK CCCCCCCCCCCCCCC	39.20	23140645
1013	Phosphorylation	RSGSRKGSWGHESPE CCCCCCCCCCCCCHH	32.68	23684622
1018	Phosphorylation	KGSWGHESPEERRSG CCCCCCCCHHHHHCC	31.75	23684622
1035	Phosphorylation	DFIRSKIYRSQSPHY HHHHHHHHHCCCCCC	14.14	25168779
1037	Phosphorylation	IRSKIYRSQSPHYFQ HHHHHHHCCCCCCCC	20.31	27742792
1039	Phosphorylation	SKIYRSQSPHYFQSG HHHHHCCCCCCCCCC	18.19	25521595
1042	Phosphorylation	YRSQSPHYFQSGRGE HHCCCCCCCCCCCCC	13.49	28833060
1045	Phosphorylation	QSPHYFQSGRGEGPG CCCCCCCCCCCCCCC	22.13	28833060
1069	Phosphorylation	SKGAGLPSQNSNTGT CCCCCCCCCCCCCCC	47.22	25159016
1072	Phosphorylation	AGLPSQNSNTGTGRG CCCCCCCCCCCCCCC	28.29	25159016
1074	Phosphorylation	LPSQNSNTGTGRGSE CCCCCCCCCCCCCCC	35.62	25159016
1076	Phosphorylation	SQNSNTGTGRGSESD CCCCCCCCCCCCCCC	22.97	25159016
1080	Phosphorylation	NTGTGRGSESDCSPE CCCCCCCCCCCCCHH	32.35	30635358
1082	Phosphorylation	GTGRGSESDCSPEDK CCCCCCCCCCCHHHH	45.69	25159016
1085	Phosphorylation	RGSESDCSPEDKNSV CCCCCCCCHHHHCHH	35.99	30635358
1100	Acetylation	TARLLLEKIQSRKVE HHHHHHHHHHHCCCC	46.12	23806337
1119	Phosphorylation	VCEEVLATPNKAGLK CCHHHHCCCCCCCCC	24.19	30482847
1146	Acetylation	LPPSLGNKPVLPMIG CCHHHCCCCCHHHCC	34.40	23806337
1168	Phosphorylation	SNKKCEESGLERGEE HCCHHHHHCCCCCCC	26.78	25168779
1179	Phosphorylation	RGEEQEHSEPEEGSP CCCCCCCCCCCCCCC	54.84	25521595
1185	Phosphorylation	HSEPEEGSPRSSDAP CCCCCCCCCCCCCCC	22.03	25521595
1188	Phosphorylation	PEEGSPRSSDAPFGH CCCCCCCCCCCCCCC	35.63	25619855
1189	Phosphorylation	EEGSPRSSDAPFGHQ CCCCCCCCCCCCCCC	38.79	25619855
1198	Phosphorylation	APFGHQFSEEAAGPL CCCCCCCCHHHCCCC	28.14	25619855
1206	Phosphorylation	EEAAGPLSDPPPEEP HHHCCCCCCCCCCCC	51.72	27818261
1341	Ubiquitination	IQQQLLAKQVKAFPA HHHHHHHHHHHCCCC	56.44	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GPTC8_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GPTC8_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GPTC8_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of GPTC8_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.