GPR39_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GPR39_HUMAN
• UniProt AC: O43194
• Protein Name: G-protein coupled receptor 39
• Gene Name: GPR39
• Organism: Homo sapiens (Human).
• Sequence Length: 453
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: Zn(2+) acts as an agonist. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated mainly through G(q)-alpha and G(12)/G(13) proteins. Involved in regulation of body weight, gastrointestinal mobility, hormone secretion and cell death (By similarity)..
• Protein Sequence: MASPSLPGSDCSQIIDHSHVPEFEVATWIKITLILVYLIIFVMGLLGNSATIRVTQVLQKKGYLQKEVTDHMVSLACSDILVFLIGMPMEFYSIIWNPLTTSSYTLSCKLHTFLFEACSYATLLHVLTLSFERYIAICHPFRYKAVSGPCQVKLLIGFVWVTSALVALPLLFAMGTEYPLVNVPSHRGLTCNRSSTRHHEQPETSNMSICTNLSSRWTVFQSSIFGAFVVYLVVLLSVAFMCWNMMQVLMKSQKGSLAGGTRPPQLRKSESEESRTARRQTIIFLRLIVVTLAVCWMPNQIRRIMAAAKPKHDWTRSYFRAYMILLPFSETFFYLSSVINPLLYTVSSQQFRRVFVQVLCCRLSLQHANHEKRLRVHAHSTTDSARFVQRPLLFASRRQSSARRTEKIFLSTFQSEAEPQSKSQSLSLESLEPNSGAKPANSAAENGFQEHEV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
32	Phosphorylation	VATWIKITLILVYLI HHHHHHHHHHHHHHH	11.62	24043423
37	Phosphorylation	KITLILVYLIIFVMG HHHHHHHHHHHHHHH	6.69	24043423
49	Phosphorylation	VMGLLGNSATIRVTQ HHHHHCCCHHHHHHH	25.62	24043423
51	Phosphorylation	GLLGNSATIRVTQVL HHHCCCHHHHHHHHH	14.77	24043423
147	Phosphorylation	PFRYKAVSGPCQVKL CCCCCCCCCCCCCHH	41.71	23532336
192	N-linked_Glycosylation	SHRGLTCNRSSTRHH CCCCCCCCCCCCCCC	41.45	UniProtKB CARBOHYD
206	N-linked_Glycosylation	HEQPETSNMSICTNL CCCCCCCCCEEECCH	35.32	UniProtKB CARBOHYD
212	N-linked_Glycosylation	SNMSICTNLSSRWTV CCCEEECCHHHCCHH	33.25	UniProtKB CARBOHYD
218	Phosphorylation	TNLSSRWTVFQSSIF CCHHHCCHHHHHHHH	15.44	24043423
222	Phosphorylation	SRWTVFQSSIFGAFV HCCHHHHHHHHHHHH	17.59	24043423
223	Phosphorylation	RWTVFQSSIFGAFVV CCHHHHHHHHHHHHH	15.91	24043423
231	Phosphorylation	IFGAFVVYLVVLLSV HHHHHHHHHHHHHHH	6.62	24043423
237	Phosphorylation	VYLVVLLSVAFMCWN HHHHHHHHHHHHHHH	13.77	24043423
256	Phosphorylation	LMKSQKGSLAGGTRP HHHHCCCCCCCCCCC	23.29	30266825
281	Phosphorylation	SRTARRQTIIFLRLI HHHHHHHHHHHHHHH	17.77	-
315	Phosphorylation	AKPKHDWTRSYFRAY HCCCCHHCHHHHHHH	18.78	24719451
380	Phosphorylation	RLRVHAHSTTDSARF CEEEEEECCCCHHHH	33.51	20639409
381	Phosphorylation	LRVHAHSTTDSARFV EEEEEECCCCHHHHH	25.42	20639409
382	Phosphorylation	RVHAHSTTDSARFVQ EEEEECCCCHHHHHH	30.85	20639409
384	Phosphorylation	HAHSTTDSARFVQRP EEECCCCHHHHHHHH	21.17	20639409
396	Phosphorylation	QRPLLFASRRQSSAR HHHHHHHHCCHHHHH	22.21	30266825
411	Phosphorylation	RTEKIFLSTFQSEAE HHHHHHHHHHCCCCC	19.20	28857561
412	Phosphorylation	TEKIFLSTFQSEAEP HHHHHHHHHCCCCCC	28.04	28857561
415	Phosphorylation	IFLSTFQSEAEPQSK HHHHHHCCCCCCCCC	34.28	28857561
421	Phosphorylation	QSEAEPQSKSQSLSL CCCCCCCCCCCCCCH	45.02	20639409
423	Phosphorylation	EAEPQSKSQSLSLES CCCCCCCCCCCCHHH	30.19	22199227
425	Phosphorylation	EPQSKSQSLSLESLE CCCCCCCCCCHHHCC	27.32	33259812
427	Phosphorylation	QSKSQSLSLESLEPN CCCCCCCCHHHCCCC	35.02	25849741
430	Phosphorylation	SQSLSLESLEPNSGA CCCCCHHHCCCCCCC	43.24	28355574
435	Phosphorylation	LESLEPNSGAKPANS HHHCCCCCCCCCCCH	51.33	20639409
442	Phosphorylation	SGAKPANSAAENGFQ CCCCCCCHHHHCCCC	30.84	20639409

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GPR39_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GPR39_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GPR39_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of GPR39_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.