GPM6A_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GPM6A_RAT
• UniProt AC: Q812E9
• Protein Name: Neuronal membrane glycoprotein M6-a
• Gene Name: Gpm6a
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 278
• Subcellular Localization: Cell membrane; Multi-pass membrane protein. Cell projection, axon. Cell projection, dendritic spine. Cell projection, filopodium. Localizes to cholesterol-rich lipid rafts of the plasma membrane of hippocampal neurons. Localized to plasma membrane of
• Protein Description: Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells (By similarity). Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. Gpm6a-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor..
• Protein Sequence: MEENMEEGQTQKGCFECCIKCLGGIPYASLIATILLYAGVALFCGCGHEALSGTVNILQTYFEMARTAGDTLDVFTMIDIFKYVIYGIAAAFFVYGILLMVEGFFTTGAIKDLYGDFKITTCGRCVSAWFIMLTYLFMLAWLGVTAFTSLPVYMYFNVWTICRNTTLVEGANLCLDLRQFGIVTIGEEKKICTVSENFLRMCESTELNMTFHLFIVALAGAGAAVIAMVHYLMVLSANWAYVKDACRMQKYEDIKSKEEQELHDIHSTRSKERLNAYT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEENMEEG -------CCCCCCCC	15.27	-
10	Phosphorylation	ENMEEGQTQKGCFEC CCCCCCCCCCCHHHH	43.00	12359212
164	N-linked_Glycosylation	NVWTICRNTTLVEGA CHHHHCCCCCCCCCC	32.76	-
208	N-linked_Glycosylation	MCESTELNMTFHLFI HHHCCCCHHHHHHHH	22.63	-
250	Acetylation	KDACRMQKYEDIKSK HHHHHCCCHHHHCCH	41.06	22902405
250	Ubiquitination	KDACRMQKYEDIKSK HHHHHCCCHHHHCCH	41.06	-
255	Ubiquitination	MQKYEDIKSKEEQEL CCCHHHHCCHHHHHH	68.73	-
256	Phosphorylation	QKYEDIKSKEEQELH CCHHHHCCHHHHHHH	45.71	30411139
257	Acetylation	KYEDIKSKEEQELHD CHHHHCCHHHHHHHH	61.34	22902405
257	Ubiquitination	KYEDIKSKEEQELHD CHHHHCCHHHHHHHH	61.34	-
267	Phosphorylation	QELHDIHSTRSKERL HHHHHHHHCCCHHHH	26.33	30411139
268	Phosphorylation	ELHDIHSTRSKERLN HHHHHHHCCCHHHHH	25.46	30411139
270	Phosphorylation	HDIHSTRSKERLNAY HHHHHCCCHHHHHCC	38.67	30411139
278	Phosphorylation	KERLNAYT------- HHHHHCCC-------	29.71	22673903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
10	T	Phosphorylation	Kinase	PRKCA	P05696	GPS
267	S	Phosphorylation	Kinase	PRKCA	P05696	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GPM6A_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GPM6A_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of GPM6A_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.