| UniProt ID | GPC4_MOUSE | |
|---|---|---|
| UniProt AC | P51655 | |
| Protein Name | Glypican-4 | |
| Gene Name | Gpc4 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 557 | |
| Subcellular Localization |
Cell membrane Lipid-anchor, GPI-anchor Extracellular side. Secreted glypican-4: Secreted, extracellular space. |
|
| Protein Description | Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system.. | |
| Protein Sequence | MARLGLLALLCTLAALSASLLAAELKSKSCSEVRRLYVSKGFNKNDAPLYEINGDHLKICPQDYTCCSQEMEEKYSLQSKDDFKTVVSEQCNHLQAIFASRYKKFDEFFKELLENAEKSLNDMFVKTYGHLYMQNSELFKDLFVELKRYYVAGNVNLEEMLNDFWARLLERMFRLVNSQYHFTDEYLECVSKYTEQLKPFGDVPRKLKLQVTRAFVAARTFAQGLAVARDVVSKVSVVNPTAQCTHALLKMIYCSHCRGLVTVKPCYNYCSNIMRGCLANQGDLDFEWNNFIDAMLMVAERLEGPFNIESVMDPIDVKISDAIMNMQDNSVQVSQKVFQGCGPPKPLPAGRISRSISESAFSARFRPYHPEQRPTTAAGTSLDRLVTDVKEKLKQAKKFWSSLPSTVCNDERMAAGNENEDDCWNGKGKSRYLFAVTGNGLANQGNNPEVQVDTSKPDILILRQIMALRVMTSKMKNAYNGNDVDFFDISDESSGEGSGSGCEYQQCPSEFEYNATDHSGKSANEKADSAGGAHAEAKPYLLAALCILFLAVQGEWR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 64 | Phosphorylation | LKICPQDYTCCSQEM EEECCCCCCCCCHHH | 9.09 | 20139300 | |
| 65 | Phosphorylation | KICPQDYTCCSQEME EECCCCCCCCCHHHH | 18.48 | 20139300 | |
| 68 | Phosphorylation | PQDYTCCSQEMEEKY CCCCCCCCHHHHHHH | 31.18 | 20139300 | |
| 220 | Phosphorylation | RAFVAARTFAQGLAV HHHHHHHHHHHHHHH | 20.70 | 21454597 | |
| 341 | S-palmitoylation | SQKVFQGCGPPKPLP HHHHHCCCCCCCCCC | 5.27 | 26165157 | |
| 357 | Phosphorylation | GRISRSISESAFSAR CHHCCHHCHHHHHCC | 27.09 | 29514104 | |
| 359 | Phosphorylation | ISRSISESAFSARFR HCCHHCHHHHHCCCC | 28.02 | 27357545 | |
| 398 | Acetylation | EKLKQAKKFWSSLPS HHHHHHHHHHHCCCH | 55.89 | 22826441 | |
| 494 | O-linked_Glycosylation | FDISDESSGEGSGSG EECCCCCCCCCCCCC | 38.52 | - | |
| 498 | O-linked_Glycosylation | DESSGEGSGSGCEYQ CCCCCCCCCCCCCCC | 26.03 | - | |
| 500 | O-linked_Glycosylation | SSGEGSGSGCEYQQC CCCCCCCCCCCCCCC | 41.80 | - | |
| 514 | N-linked_Glycosylation | CPSEFEYNATDHSGK CCCCEEECCCCCCCC | 29.21 | - | |
| 529 | GPI-anchor | SANEKADSAGGAHAE CHHHCCCCCCCCCCC | 33.40 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GPC4_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GPC4_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GPC4_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of GPC4_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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