dbPTM

GP180_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GP180_HUMAN
UniProt AC	Q86V85
Protein Name	Integral membrane protein GPR180
Gene Name	GPR180
Organism	Homo sapiens (Human).
Sequence Length	440
Subcellular Localization	Membrane Multi-pass membrane protein .
Protein Description
Protein Sequence	MGGLRLLAVALTCCWWPQGSQGKTLRGSFSSTAAQDAQGQRIGHFEFHGDHALLCVRINNIAVAVGKEAKLYLFQAQEWLKLQQSSHGYSCSEKLSKAQLTMTMNQTEHNLTVSQIPSPQTWHVFYADKYTCQDDKENSQVEDIPFEMVLLNPDAEGNPFDHFSAGESGLHEFFFLLVLVYFVIACIYAQSLWQAIKKGGPMHMILKVLTTALLLQAGSALANYIHFSSYSKDGIGVPFMGSLAEFFDIASQIQMLYLLLSLCMGWTIVRMKKSQSRPLQWDSTPASTGIAVFIVMTQSVLLLWEQFEDISHHSYHSHHNLAGILLIVLRICLALSLGCGLYQIITVERSTLKREFYITFAKGCILWFLCHPVLACISVIFSDYQRDKVITIGVILCQSVSMVILYRLFLSHSLYWEVSSLSSVTLPLTISSGHKSRPHF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
26	Methylation	GSQGKTLRGSFSSTA CCCCCEEEECEECCC	43.89	-
67	Ubiquitination	NIAVAVGKEAKLYLF CEEEEECCCEEEEEE	48.15	-
94	Ubiquitination	HGYSCSEKLSKAQLT CCCCHHHHHHHHHEE	41.59	29967540
94	Acetylation	HGYSCSEKLSKAQLT CCCCHHHHHHHHHEE	41.59	26051181
105	N-linked_Glycosylation	AQLTMTMNQTEHNLT HHEEEEECCCCCCEE	36.13	UniProtKB CARBOHYD
110	N-linked_Glycosylation	TMNQTEHNLTVSQIP EECCCCCCEEEECCC	31.04	UniProtKB CARBOHYD
420	Phosphorylation	SLYWEVSSLSSVTLP CCEEEHHCCCCCEEE	37.13	22468782
429	Phosphorylation	SSVTLPLTISSGHKS CCCEEEEEEECCCCC	19.51	22468782

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of GP180_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GP180_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GP180_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
CLUS_HUMAN	CLU	physical	26186194

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GP180_HUMAN

Related Literatures of Post-Translational Modification