GP119_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GP119_HUMAN
• UniProt AC: Q8TDV5
• Protein Name: Glucose-dependent insulinotropic receptor
• Gene Name: GPR119
• Organism: Homo sapiens (Human).
• Sequence Length: 335
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway..
• Protein Sequence: MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
67	Phosphorylation	GLLTDQLSSPSRPTQ HHHHCCCCCCCCCCH	34.27	24719451
201	Ubiquitination	MHSQQIRKMEHAGAM HHHHHHHHHHHHCCC	50.71	22817900
226	Phosphorylation	SDFKALRTVSVLIGS HHHHHHHHHHHHHHH	20.27	22210691
244	Phosphorylation	SWTPFLITGIVQVAC CCCHHHHHHHHHHHH	24.01	22210691
257	Phosphorylation	ACQECHLYLVLERYL HHHHHHHHHHHHHHH	3.23	22210691
302	Phosphorylation	LGVKKVLTSFLLFLS HHHHHHHHHHHHHHH	22.03	-
303	Phosphorylation	GVKKVLTSFLLFLSA HHHHHHHHHHHHHHH	15.10	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GP119_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GP119_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GP119_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of GP119_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.