dbPTM

GOGC6_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GOGC6_ARATH
UniProt AC	B0F9L4
Protein Name	Golgin candidate 6
Gene Name	GC6
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	914
Subcellular Localization	Golgi apparatus . Golgi apparatus, Golgi stack . Concentrates only on one side of the Golgi bodies.
Protein Description	Golgi matrix protein playing a role in tethering of vesicles to Golgi membranes and in maintaining the overall structure of the Golgi apparatus. Functions in the anterograde transport of storage protein precursors from the endoplasmic reticulum (ER) to the Golgi complex..
Protein Sequence	MDLASRYKGVVGMVFGDNQSSNEDSYIQRLLDRISNGTLPDDRRTAIVELQSVVAESNAAQLAFGAAGFPVIVGILKDQRDDLEMVRGALETLLGALTPIDHARAQKTEVQAALMNSDLLSREAENITLLLSLLEEEDFYVRYYTLQILTALLMNSQNRLQEAILTTPRGITRLMDMLMDREVIRNEALLLLTHLTREAEEIQKIVVFEGAFEKIFSIIKEEGGSDGDVVVQDCLELLNNLLRSSSSNQILLRETMGFEPIISILKLRGITYKFTQQKTVNLLSALETINMLIMGRADTEPGKDSNKLANRTVLVQKKLLDYLLMLGVESQWAPVAVRCMTFKCIGDLIDGHPKNRDILASKVLGEDRQVEPALNSILRIILQTSSIQEFVAADYVFKTFCEKNTEGQTMLASTLIPQPHPTSRDHLEDDVHMSFGSMLLRGLCSGEADGDLETCCRAASILSHVVKDNLRCKEKALKIVLESPMPSMGTPEPLFQRIVRYLAVASSMKSKEKSSTLGKSYIQQIILKLLVTWTVDCPTAVQCFLDSRHHLTFLLELVTDPAATVCIRGLASILLGECVIYNKSIENGKDAFSVVDAVGQKMGLTSYFSKFEEMQNSFIFSPSKKPPQGYKPLTRTPTPSEAEINEVDEVDEMVKGNEDHPMLLSLFDASFIGLVKSLEGNIRERIVDVYSRPKSEVAVVPADLEQKSGENEKDYINRLKAFIEKQCSEIQNLLARNAALAEDVASSGRNEQSQGSEQRASTVMDKVQMESIRRELQETSQRLETVKAEKAKIESEASSNKNMAAKLEFDLKSLSDAYNSLEQANYHLEQEVKSLKGGESPMQFPDIEAIKEEVRKEAQKESEDELNDLLVCLGQEESKVEKLSAKLIELGVDVDKLLEDIGDESEAQAESEED

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
244	Phosphorylation	LLNNLLRSSSSNQIL HHHHHHCCCCCCCHH	34.24	28011693
245	Phosphorylation	LNNLLRSSSSNQILL HHHHHCCCCCCCHHH	31.21	28011693
246	Phosphorylation	NNLLRSSSSNQILLR HHHHCCCCCCCHHHH	34.26	28011693
247	Phosphorylation	NLLRSSSSNQILLRE HHHCCCCCCCHHHHH	34.40	28011693
405	Phosphorylation	KTFCEKNTEGQTMLA HHHHCCCCCCCEEEE	53.19	22074104
506	Phosphorylation	VRYLAVASSMKSKEK HHHHHHHHHCCCCHH	25.11	19880383
507	Phosphorylation	RYLAVASSMKSKEKS HHHHHHHHCCCCHHC	22.08	23820729
636	Phosphorylation	GYKPLTRTPTPSEAE CCCCCCCCCCCCHHH	26.69	23111157
638	Phosphorylation	KPLTRTPTPSEAEIN CCCCCCCCCCHHHCC	38.54	23660473
640	Phosphorylation	LTRTPTPSEAEINEV CCCCCCCCHHHCCCC	52.49	23660473
840	Phosphorylation	KSLKGGESPMQFPDI HHCCCCCCCCCCCCH	29.01	27288362
905	Phosphorylation	LEDIGDESEAQAESE HHHHCCHHHHHHHHC	42.86	23776212
911	Phosphorylation	ESEAQAESEED---- HHHHHHHHCCC----	49.67	30291188

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of GOGC6_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GOGC6_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GOGC6_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of GOGC6_ARATH !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GOGC6_ARATH

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks."; Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.; Plant Physiol. 150:889-903(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-911, AND MASSSPECTROMETRY.	19376835 [Abstract]
"Site-specific phosphorylation profiling of Arabidopsis proteins bymass spectrometry and peptide chip analysis."; de la Fuente van Bentem S., Anrather D., Dohnal I., Roitinger E.,Csaszar E., Joore J., Buijnink J., Carreri A., Forzani C.,Lorkovic Z.J., Barta A., Lecourieux D., Verhounig A., Jonak C.,Hirt H.; J. Proteome Res. 7:2458-2470(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-911, AND MASSSPECTROMETRY.	18433157 [Abstract]