GNDS_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GNDS_MOUSE
• UniProt AC: Q03385
• Protein Name: Ral guanine nucleotide dissociation stimulator
• Gene Name: Ralgds
• Organism: Mus musculus (Mouse).
• Sequence Length: 852
• Subcellular Localization: Cytoplasm . Nucleus . Localizes mainly in the peripheral region of the cytoplasmic membrane in oocytes and in preimplantation embryos until the 8-cell stage. Between the late 1-cell and the early 2-cell stages, nuclear localization becomes stronger.
• Protein Description: Stimulates the dissociation of GDP from the Ras-related RalA and RalB GTPases which allows GTP binding and activation of the GTPases. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap..
• Protein Sequence: MMVDCQSSTQEIGEELINGVIYSISLRKVQLHQGATKGQRWLGCENESALNLYETCKVRTVKAGTLEKLVEHLVPAFQGSDLSYVTVFLCTYRAFTTTQQVLDLLFKRYGRCDALTASSRYGCILPYSSEDGGPQDQLKNAISSILGTWLDQYSEDFCQPPDFPCLKQLVAYVQLNMPGSDLERRAHLLLAQLEDLEPSEAESEALSPAPVLSLKPASQLEPALLLTPSQVVTSTPVREPAAAPVPVLASSPVVAPAPELEPVPEPPQEPEPSLALAPELEPAVSQSLELESAPVPTPALEPSWSLPEATENGLTEKPHLLLFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVAQFNNVANCVITTCLGDQSMKAPDRARVVEHWIEVARECRALKNFSSLYAILSALQSNAIHRLKKTWEEVSRDSFRVFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPRRAQRRQKETGVIQGTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNYSIAPEEHFGTWFRAMERLSEAESYTLSCELEPPSESASNTLRSKKSTAIVKRWSDRQAPSTELSTSSSAHSKSCDQLRCSPYLGSGDITDALSVHSAGSSSSDVEEINMSFVPESPDGQEKKFWESASQSSPETSGISSASSSTSSSSASTTPVSTTRTHKRSVSGVCSYSSSLPLYNQQVGDCCIIRVSLDVDNGNMYKSILVTSQDKAPTVIRKAMDKHNLDEDEPEDYELVQIISEDHKLKIPENANVFYAMNSTANYDFILKKRTFTKGAKVKHGASSTLPRMKQKGLRIAKGIF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
53	Phosphorylation	NESALNLYETCKVRT CHHHHHHHHHCCEEE	14.23	-
213	Phosphorylation	LSPAPVLSLKPASQL CCCCCCCCCCCHHHC	34.28	30387612
458	Phosphorylation	QKLSEIFSDENNYSL HHHHHHHCCCCCCCC	50.07	29899451
463	Phosphorylation	IFSDENNYSLSRELL HHCCCCCCCCCHHHH	23.67	-
480	Phosphorylation	EGTSKFATLEMNPRR CCCCCCEEEECCHHH	26.78	29514104
607	Phosphorylation	TAIVKRWSDRQAPST HHHHHCCCCCCCCCC	27.27	26643407
613	Phosphorylation	WSDRQAPSTELSTSS CCCCCCCCCCCCCCC	37.21	26060331
619	Phosphorylation	PSTELSTSSSAHSKS CCCCCCCCCCCCCCC	20.94	26060331
626	Phosphorylation	SSSAHSKSCDQLRCS CCCCCCCCCCCCCCC	26.41	29514104
692	Phosphorylation	PETSGISSASSSTSS CCCCCCCCCCCCCCC	30.19	-
697	Phosphorylation	ISSASSSTSSSSAST CCCCCCCCCCCCCCC	34.28	-
701	Phosphorylation	SSSTSSSSASTTPVS CCCCCCCCCCCCCCC	28.34	-
710	Phosphorylation	STTPVSTTRTHKRSV CCCCCCCCCCCCCCC	26.51	-
752	Phosphorylation	DVDNGNMYKSILVTS ECCCCCEEEEEEEEC	12.94	-
784	Phosphorylation	DEDEPEDYELVQIIS CCCCCCHHHHHEEEC	14.97	-
806	Phosphorylation	PENANVFYAMNSTAN CCCCCEEEEEECCCC	10.72	22324799
810	Phosphorylation	NVFYAMNSTANYDFI CEEEEEECCCCCCEE	18.80	22324799
811	Phosphorylation	VFYAMNSTANYDFIL EEEEEECCCCCCEEE	17.58	22324799
814	Phosphorylation	AMNSTANYDFILKKR EEECCCCCCEEECCC	15.12	22324799
834	Phosphorylation	AKVKHGASSTLPRMK CCCCCCCCCCHHHHH	28.57	29550500
835	Phosphorylation	KVKHGASSTLPRMKQ CCCCCCCCCHHHHHH	33.17	29550500
836	Phosphorylation	VKHGASSTLPRMKQK CCCCCCCCHHHHHHH	37.98	29550500

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
752	Y	Phosphorylation	Kinase	MET	P16056	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GNDS_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GNDS_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of GNDS_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.