GNAS2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GNAS2_RAT
• UniProt AC: P63095
• Protein Name: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
• Gene Name: Gnas
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 394
• Subcellular Localization: Cell membrane ; Lipid-anchor .
• Protein Description: Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. Stimulates the Ras signaling pathway via RAPGEF2..
• Protein Sequence: MGCLGNSKTEDQRNEEKAQREANKKIEKQLQKDKQVYRATHRLLLLGAGESGKSTIVKQMRILHVNGFNGEGGEEDPQAARSNSDGEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVPNFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLDKIDVIKQADYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVASSSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYPHFTCAVDTENIRRVFNDCRDIIQRMHLRQYELL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	N-palmitoylation	------MGCLGNSKT ------CCCCCCCCC	18.50	-
3	S-palmitoylation	-----MGCLGNSKTE -----CCCCCCCCCH	4.20	8227063
53	Ubiquitination	LGAGESGKSTIVKQM HCCCCCCCCHHHEEE	54.42	-
58	Ubiquitination	SGKSTIVKQMRILHV CCCCHHHEEEEEEEE	34.23	-
177	Phosphorylation	QLIDCAQYFLDKIDV EEHHHHHHHHHHCHH	6.38	-
186	Ubiquitination	LDKIDVIKQADYVPS HHHCHHHHHCCCCCC	39.00	-
211	Acetylation	TSGIFETKFQVDKVN CCCCCEEEEEEEEEE	26.97	14496249
311	Phosphorylation	GKSKIEDYFPEFARY CCHHHHHHCHHHHCC	14.29	-
352	Phosphorylation	FLRISTASGDGRHYC HHEEEECCCCCCCCE	37.19	22673903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GNAS2_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GNAS2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GNAS2_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of GNAS2_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Palmitoylation

"The G protein alpha s subunit incorporates [3H]palmitic acid andmutation of cysteine-3 prevents this modification.";
Degtyarev M.Y., Spiegel A.M., Jones T.L.Z.;
Biochemistry 32:8057-8061(1993).
Cited for: PALMITOYLATION AT CYS-3, AND MUTAGENESIS OF CYS-3.
PubMed: 8347607