GNAQ_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GNAQ_RAT
• UniProt AC: P82471
• Protein Name: Guanine nucleotide-binding protein G(q) subunit alpha
• Gene Name: Gnaq
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 359
• Subcellular Localization: Nucleus. Membrane. Nucleus membrane. Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes..
• Protein Description: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems..
• Protein Sequence: MTLESIMACCLSEEAKEARRINDEIERQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSDEDKRGFTKLVYQNIFTAMQAMVRAMDTLKIPYKYEHNKAHAQLVREVDVEKVSAFENPYVDAIKSLWNDPGIQECYDRRREYQLSDSTKYYLNDLDRVADPSYLPTQQDVLRVRVPTTGIIEYPFDLQSVIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEEKIMYSHLVDYFPEYDGPQRDAQAAREFILKMFVDLNPDSDKIIYSHFTCATDTENIRFVFAAVKDTILQLNLKEYNLV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	S-palmitoylation	TLESIMACCLSEEAK CHHHHHHHHCCHHHH	1.01	-
10	S-palmitoylation	LESIMACCLSEEAKE HHHHHHHHCCHHHHH	3.21	-
47	Phosphorylation	LKLLLLGTGESGKST HHHHHHHCCCCCCHH	37.43	22673903
50	Phosphorylation	LLLGTGESGKSTFIK HHHHCCCCCCHHHHE	53.52	22673903
53	Phosphorylation	GTGESGKSTFIKQMR HCCCCCCHHHHEEEE	31.88	22673903
54	Phosphorylation	TGESGKSTFIKQMRI CCCCCCHHHHEEEEE	32.63	22673903
102	Acetylation	DTLKIPYKYEHNKAH HHCCCCCCCCCCHHH	38.52	22902405
102	Ubiquitination	DTLKIPYKYEHNKAH HHCCCCCCCCCCHHH	38.52	-
120	Acetylation	VREVDVEKVSAFENP HHCCCHHHHHCCCCH	41.14	22902405
158	Ubiquitination	YQLSDSTKYYLNDLD EECCCCCCCCCCCHH	35.53	-
209	Formation of an isopeptide bond	RMVDVGGQRSERRKW EEECCCCCCCHHHHH	39.54	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GNAQ_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GNAQ_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GNAQ_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of GNAQ_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.