GLYM1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GLYM1_ARATH
• UniProt AC: Q9SZJ5
• Protein Name: Serine hydroxymethyltransferase 1, mitochondrial
• Gene Name: SHM1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 517
• Subcellular Localization: Mitochondrion . Cytoplasm.
• Protein Description: Functions in the photorespiratory pathway in catalyzing the interconversion of serine and glycine. Involved in controlling cell damage caused by abiotic stress, such as high light and salt and the hypersensitive defense response of plants..
• Protein Sequence: MAMAMALRRLSSSIDKPIRPLIRSTSCYMSSLPSEAVDEKERSRVTWPKQLNAPLEEVDPEIADIIEHEKARQWKGLELIPSENFTSVSVMQAVGSVMTNKYSEGYPGARYYGGNEYIDMAETLCQKRALEAFRLDPEKWGVNVQPLSGSPANFHVYTALLKPHERIMALDLPHGGHLSHGYQTDTKKISAVSIFFETMPYRLDESTGYIDYDQMEKSATLFRPKLIVAGASAYARLYDYARIRKVCNKQKAVMLADMAHISGLVAANVIPSPFDYADVVTTTTHKSLRGPRGAMIFFRKGVKEINKQGKEVLYDFEDKINQAVFPGLQGGPHNHTITGLAVALKQATTSEYKAYQEQVLSNSAKFAQTLMERGYELVSGGTDNHLVLVNLKPKGIDGSRVEKVLEAVHIASNKNTVPGDVSAMVPGGIRMGTPALTSRGFVEEDFAKVAEYFDKAVTIALKVKSEAQGTKLKDFVSAMESSSTIQSEIAKLRHEVEEFAKQFPTIGFEKETMKYKN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	AMALRRLSSSIDKPI HHHHHHHHHCCCCCC		25561503
12	Phosphorylation	MALRRLSSSIDKPIR HHHHHHHHCCCCCCH		25561503
13	Phosphorylation	ALRRLSSSIDKPIRP HHHHHHHCCCCCCHH		25561503
25	Phosphorylation	IRPLIRSTSCYMSSL CHHHHHCCCCCCCCC		28011693
26	Phosphorylation	RPLIRSTSCYMSSLP HHHHHCCCCCCCCCC		19880383
28	Phosphorylation	LIRSTSCYMSSLPSE HHHCCCCCCCCCCHH		28011693
30	Phosphorylation	RSTSCYMSSLPSEAV HCCCCCCCCCCHHHC		28011693
31	Phosphorylation	STSCYMSSLPSEAVD CCCCCCCCCCHHHCC		19376835
46	Phosphorylation	EKERSRVTWPKQLNA HHHHHCCCCCHHHCC		19880383
70	Acetylation	ADIIEHEKARQWKGL HHHHHHHHHHHCCCC		24727099
87	Phosphorylation	IPSENFTSVSVMQAV CCCCCCCCHHHHHHH		28011693
89	Phosphorylation	SENFTSVSVMQAVGS CCCCCCHHHHHHHHH		28011693
286	N6-(pyridoxal phosphate)lysine	VVTTTTHKSLRGPRG EEEECCCHHHCCCCC		-
286	Other	VVTTTTHKSLRGPRG EEEECCCHHHCCCCC		-
303	Acetylation	IFFRKGVKEINKQGK EEEECCHHHHHHCCC		24727099
310	Acetylation	KEINKQGKEVLYDFE HHHHHCCCEEEEEHH		24727099
392	Acetylation	HLVLVNLKPKGIDGS EEEEEECCCCCCCCH		24727099
403	Acetylation	IDGSRVEKVLEAVHI CCCHHHHHHHHHHHH		24727099
416	Phosphorylation	HIASNKNTVPGDVSA HHHCCCCCCCCCHHH		22092075
455	Acetylation	KVAEYFDKAVTIALK HHHHHHHHHHHHEHH		24727099
470	Phosphorylation	VKSEAQGTKLKDFVS HCCCCCCCCHHHHHH		25561503
471	Acetylation	KSEAQGTKLKDFVSA CCCCCCCCHHHHHHH		24727099
473	Acetylation	EAQGTKLKDFVSAME CCCCCCHHHHHHHHH		24727099
510	Acetylation	FPTIGFEKETMKYKN CCCCCCCCCCCCCCC		24727099

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GLYM1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GLYM1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GLYM1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBP16_ARATH	UBP16	physical	23232097
UBP16_ARATH	UBP16	physical	23857362
GLTB1_ARATH	GLU1	genetic	19223513
GLTB1_ARATH	GLU1	physical	19223513

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.