dbPTM

GLYC_CAEEL - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GLYC_CAEEL
UniProt AC	P50432
Protein Name	Serine hydroxymethyltransferase
Gene Name	mel-32
Organism	Caenorhabditis elegans.
Sequence Length	507
Subcellular Localization
Protein Description	Interconversion of serine and glycine..
Protein Sequence	MFARIVSRRAATGLFAGASSQCKMADRQVHTPLAKVQRHKYTNNENILVDHVEKVDPEVFDIMKNEKKRQRRGLELIASENFTSKAVMDALGSAMCNKYSEGYPGARYYGGNEFIDQMELLCQKRALEVFGLDPAKWGVNVQPLSGSPANFAVYTAIVGSNGRIMGLDLPDGGHLTHGFFTPARKVSATSEFFQSLPYKVDPTTGLIDYDKLEQNAMLFRPKAIIAGVSCYARHLDYERFRKIATKAGAYLMSDMAHISGLVAAGLIPSPFEYSDVVTTTTHKSLRGPRGALIFYRKGVRSTNAKGVDTLYDLEEKINSAVFPGLQGGPHNHTIAGIAVALRQCLSEDFVQYGEQVLKNAKTLAERMKKHGYALATGGTDNHLLLVDLRPIGVEGARAEHVLDLAHIACNKNTCPGDVSALRPGGIRLGTPALTSRGFQEQDFEKVGDFIHEGVQIAKKYNAEAGKTLKDFKSFTETNEPFKKDVADLAKRVEEFSTKFEIPGNETF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Phosphorylation	MADRQVHTPLAKVQR CCCCCCCCCHHHHHH	22.57	30078680
176	Phosphorylation	LPDGGHLTHGFFTPA CCCCCCCCCCCCCCC	17.80	19530675
181	Phosphorylation	HLTHGFFTPARKVSA CCCCCCCCCCCCCCC	17.49	28854356
187	Phosphorylation	FTPARKVSATSEFFQ CCCCCCCCCCHHHHH	28.94	19060867
189	Phosphorylation	PARKVSATSEFFQSL CCCCCCCCHHHHHCC	22.68	19530675
190	Phosphorylation	ARKVSATSEFFQSLP CCCCCCCHHHHHCCC	31.93	19530675
283	N6-(pyridoxal phosphate)lysine	VVTTTTHKSLRGPRG CEEECCCHHHCCCCE	49.44	-
283	Other	VVTTTTHKSLRGPRG CEEECCCHHHCCCCE	49.44	-
506	Phosphorylation	FEIPGNETF------ CCCCCCCCC------	38.35	30078680

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of GLYC_CAEEL !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GLYC_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GLYC_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of GLYC_CAEEL !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GLYC_CAEEL

Related Literatures of Post-Translational Modification