GLTL5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GLTL5_HUMAN
• UniProt AC: Q7Z4T8
• Protein Name: Inactive polypeptide N-acetylgalactosaminyltransferase-like protein 5
• Gene Name: GALNTL5
• Organism: Homo sapiens (Human).
• Sequence Length: 443
• Subcellular Localization: Late endosome membrane ; Single-pass type II membrane protein . Localizes to the juxtanuclear region, possibly the late endosome. Not localized in the Golgi apparatus in round spermatids (By similarity)..
• Protein Description: Probable inactive glycosyltransferase required during spermatid development. May participate in protein loading into the acrosomes and accumulation of ubiquitin-proteasome systems around the head-tail coupling apparatus region..
• Protein Sequence: MRNAIIQGLFYGSLTFGIWTALLFIYLHHNHVSSWQKKSQEPLSAWSPGKKVHQQIIYGSEQIPKPHVIVKRTDEDKAKSMLGTDFNHTNPELHKELLKYGFNVIISRSLGIEREVPDTRSKMCLQKHYPARLPTASIVICFYNEECNALFQTMSSVTNLTPHYFLEEIILVDDMSKVDDLKEKLDYHLETFRGKVKIIRNKKREGLIRARLIGASHASGDVLVFLDSHCEVNRVWLEPLLHAIAKDPKMVVCPLIDVIDDRTLEYKPSPLVRGTFDWNLQFKWDNVFSYEMDGPEGSTKPIRSPAMSGGIFAIRRHYFNEIGQYDKDMDFWGRENLELSLRIWMCGGQLFIIPCSRVGHISKKQTGKPSTIISAMTHNYLRLVHVWLDEYKEQFFLRKPGLKYVTYGNIRERVELRKRLGCKSFQWYLDNVFPELEASVNSL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
87	N-linked_Glycosylation	SMLGTDFNHTNPELH HHHCCCCCCCCHHHH	43.83	UniProtKB CARBOHYD
100	Phosphorylation	LHKELLKYGFNVIIS HHHHHHHHCCEEEEE	27.24	22210691
122	Ubiquitination	EVPDTRSKMCLQKHY CCCCCCHHHHHHHHC	30.27	-
123	Sulfoxidation	VPDTRSKMCLQKHYP CCCCCHHHHHHHHCC	2.65	30846556
191	Phosphorylation	KLDYHLETFRGKVKI HHHHHHHHHHCCEEE	25.62	24719451
340	Phosphorylation	GRENLELSLRIWMCG CHHCHHHHEEEEEEC	13.26	24719451
362	Phosphorylation	CSRVGHISKKQTGKP CCCCCCCCCCCCCCC	28.29	-
366	Phosphorylation	GHISKKQTGKPSTII CCCCCCCCCCCCHHH	56.93	-
370	Phosphorylation	KKQTGKPSTIISAMT CCCCCCCCHHHHHHC	35.41	26270265
371	Phosphorylation	KQTGKPSTIISAMTH CCCCCCCHHHHHHCC	30.75	26270265
374	Phosphorylation	GKPSTIISAMTHNYL CCCCHHHHHHCCCHH	14.24	26270265
377	Phosphorylation	STIISAMTHNYLRLV CHHHHHHCCCHHHHH	13.49	26270265
380	Phosphorylation	ISAMTHNYLRLVHVW HHHHCCCHHHHHHHH	5.89	26270265
404	Phosphorylation	LRKPGLKYVTYGNIR CCCCCCEEEEECCHH	11.76	25884760
407	Phosphorylation	PGLKYVTYGNIRERV CCCEEEEECCHHHHH	9.72	25884760

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GLTL5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GLTL5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GLTL5_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of GLTL5_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.