| UniProt ID | GLR_MOUSE | |
|---|---|---|
| UniProt AC | Q61606 | |
| Protein Name | Glucagon receptor | |
| Gene Name | Gcgr | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 485 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein . Is rapidly internalized after ligand-binding. |
|
| Protein Description | G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system.. | |
| Protein Sequence | MPLTQLHCPHLLLLLLVLSCLPEAPSAQVMDFLFEKWKLYSDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPPNTTANISCPWYLPWYHKVQHRLVFKRCGPDGQWVRGPRGQPWRNASQCQLDDEEIEVQKGVAKMYSSQQVMYTVGYSLSLGALLLALVILLGLRKLHCTRNYIHGNLFASFVLKAGSVLVIDWLLKTRYSQKIGDDLSVSVWLSDGAMAGCRVATVIMQYGIIANYCWLLVEGVYLYSLLSLATFSERSFFSLYLGIGWGAPLLFVIPWVVVKCLFENVQCWTSNDNMGFWWILRIPVFLALLINFFIFVHIIHLLVAKLRAHQMHYADYKFRLARSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSTKLFFDLFLSSFQGLLVAVLYCFLNKEVQAELMRRWRQWQEGKALQEERLASSHGSHMAPAGPCHGDPCEKLQLMSAGSSSGTGCVPSMETSLASSLPRLADSPT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 47 | N-linked_Glycosylation | YSDQCHHNLSLLPPP CCCCCCCCCCCCCCC | 13.99 | - | |
| 60 | N-linked_Glycosylation | PPTELVCNRTFDKYS CCCEEEECCCCCCCC | 38.25 | - | |
| 75 | N-linked_Glycosylation | CWPDTPPNTTANISC CCCCCCCCCCCCCCC | 51.79 | - | |
| 79 | N-linked_Glycosylation | TPPNTTANISCPWYL CCCCCCCCCCCCCCC | 25.31 | - | |
| 118 | N-linked_Glycosylation | PRGQPWRNASQCQLD CCCCCCCCHHHCCCC | 39.82 | - | |
| 150 | Phosphorylation | QVMYTVGYSLSLGAL CCCHHHHHHHHHHHH | 11.34 | 28059163 | |
| 151 | Phosphorylation | VMYTVGYSLSLGALL CCHHHHHHHHHHHHH | 12.93 | 28059163 | |
| 432 | Phosphorylation | LQEERLASSHGSHMA HHHHHHHHCCCCCCC | 27.71 | 29472430 | |
| 433 | Phosphorylation | QEERLASSHGSHMAP HHHHHHHCCCCCCCC | 26.68 | 29472430 | |
| 436 | Phosphorylation | RLASSHGSHMAPAGP HHHHCCCCCCCCCCC | 12.50 | 29472430 | |
| 460 | Phosphorylation | QLMSAGSSSGTGCVP CEECCCCCCCCCCCC | 31.69 | - | |
| 475 | Phosphorylation | SMETSLASSLPRLAD CHHHHHHHHCCHHHC | 37.39 | 23140645 | |
| 476 | Phosphorylation | METSLASSLPRLADS HHHHHHHHCCHHHCC | 36.46 | 25521595 | |
| 483 | Phosphorylation | SLPRLADSPT----- HCCHHHCCCC----- | 25.49 | 25521595 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GLR_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GLR_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GLR_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of GLR_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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