GLRX5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GLRX5_MOUSE
• UniProt AC: Q80Y14
• Protein Name: Glutaredoxin-related protein 5, mitochondrial
• Gene Name: Glrx5
• Organism: Mus musculus (Mouse).
• Sequence Length: 152
• Subcellular Localization: Mitochondrion matrix .
• Protein Description: Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters (By similarity). Involved in protein lipoylation, acting in the pathway that provides an iron-sulfur cluster to lipoate synthase (By similarity). Required for normal iron homeostasis (By similarity). Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1 (By similarity). May protect cells against apoptosis due to reactive oxygen species and oxidative stress. [PubMed: 19442627]
• Protein Sequence: MSASLSRAAAALLRWGRSAGGGGLPGAGVRAASSGGQAEQLDALVKKDKVVVFLKGTPEQPQCGFSNAVVQILRLHGVRDYAAYNVLDDPELRQGIKDYSNWPTIPQVYLNGEFVGGCDILLQMHQNGDLVEELKKLGIRSALVDEKDQDSK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
49	Acetylation	DALVKKDKVVVFLKG HHHHCCCEEEEEECC	45.89	23864654
55	Succinylation	DKVVVFLKGTPEQPQ CEEEEEECCCCCCCC	49.64	-
55	Acetylation	DKVVVFLKGTPEQPQ CEEEEEECCCCCCCC	49.64	23806337
55	Succinylation	DKVVVFLKGTPEQPQ CEEEEEECCCCCCCC	49.64	23806337
63	S-nitrosocysteine	GTPEQPQCGFSNAVV CCCCCCCCCCCHHHH	8.27	-
63	Glutathionylation	GTPEQPQCGFSNAVV CCCCCCCCCCCHHHH	8.27	24333276
63	S-nitrosylation	GTPEQPQCGFSNAVV CCCCCCCCCCCHHHH	8.27	22588120
63	S-palmitoylation	GTPEQPQCGFSNAVV CCCCCCCCCCCHHHH	8.27	28526873
147	Acetylation	RSALVDEKDQDSK-- HHHHCCCCCCCCC--	57.11	23201123
147	Succinylation	RSALVDEKDQDSK-- HHHHCCCCCCCCC--	57.11	26388266
151	Phosphorylation	VDEKDQDSK------ CCCCCCCCC------	34.33	19060867
152	Acetylation	DEKDQDSK------- CCCCCCCC-------	73.06	2373511
152	Succinylation	DEKDQDSK------- CCCCCCCC-------	73.06	26388266

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GLRX5_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GLRX5_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GLRX5_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of GLRX5_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.