dbPTM

GLR1_CAEEL - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GLR1_CAEEL
UniProt AC	P34299
Protein Name	Glutamate receptor 1 {ECO:0000312\|WormBase:C06E1.4}
Gene Name	glr-1 {ECO:0000312\|WormBase:C06E1.4}
Organism	Caenorhabditis elegans.
Sequence Length	962
Subcellular Localization	Cell junction, synapse, postsynaptic cell membrane Multi-pass membrane protein . Endoplasmic reticulum . Cell junction, synapse . Cell membrane . Recycling endosome . Partially co-localizes with lin-10 at synapses (PubMed:17671168). Trafficking bet
Protein Description	Non-NMDA (N-methyl-D-aspartate) ionotropic glutamate receptor. [PubMed: 7477293 L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system]
Protein Sequence	MFSSFSFLNMFGVLFTVFNLTVVQPYPSHIIIKSFGNNEEVSRVALKAMEYTSDHINSRDDVPFKLAFDHRVVEEGAAVSWNMVNAVCDELKEGAMALLSSVDGKGREGIRGVSDALEMPLVSLTALSNDDHQQQQFGNLFEVSVRPPISELLADFIVHKGWGEVLVLIDPVHASLHLPSLWRHLRTRTNTSVKASMFDLPADEKQFEAYLMQFNMMRNNETNRILIDCASPKRLKKLLINIRSAQFNQANYHYVLANYDFLPYDQEMFQNGNINISGFNIINKDGREYWSLKKHLKTSSSLGGGDDVSVEAAVGHDAMLVTWHGFAKCLQANDSLFHGTFRHRRFFNRGFPGIYCDPLSDRSHPNRPFSSFEHGKTIGVAFRNMKIGHKEGTLTGNIEFDRFGNRKNFDVSIVDLVSNTKATFNSKEVLAWRQGVGFFSNRTVAQHSRKSQNDHKDNQVIVLTNLVAPFVMIKRECLEMANLTECQGNNKFEGFCIDLLKLLADKIEEFNYEIKLGTKAGSKQADGSWDGMIGELLSGRAHAVVASLTINQERERVVDFSKPFMTTGISIMIKKPDKQEFSVFSFMQPLSTEIWMYIIFAYIGVSVVIFLVSRFSPYEWRVEETSRGGFTISNDFSVYNCLWFTLAAFMQQGTDILPRSISGRIASSAWWFFTMIIVSSYTANLAAFLTLEKMQAPIESVEDLAKQSKIKYGIQGGGSTASFFKYSSVQIYQRMWRYMESQVPPVFVASYAEGIERVRSHKGRYAFLLEATANEYENTRKPCDTMKVGANLNSIGYGIATPFGSDWKDHINLAILALQERGELKKLENKWWYDRGQCDAGITVDGSSASLNLSKVAGIFYILMGGMVISMLAALGEFLYRSRIEARKSNSNSMVANFAKNLKSALSSQLRLSVEGGAVAQPGSQSHNAIRRQQVAAFLPANEKEAFNNVDRPANTLYNTAV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
190	N-linked_Glycosylation	RHLRTRTNTSVKASM HHHHHCCCCCCEEHH	27.37	-
220	N-linked_Glycosylation	QFNMMRNNETNRILI HHHHHHCCCCCCEEE	47.29	-
275	N-linked_Glycosylation	MFQNGNINISGFNII HHHCCCEEEECEEEE	26.77	-
333	N-linked_Glycosylation	FAKCLQANDSLFHGT HHHHHHCCCCCCCCH	26.83	-
441	N-linked_Glycosylation	QGVGFFSNRTVAQHS CCCCCCCCHHHHHHC	38.19	-
482	N-linked_Glycosylation	RECLEMANLTECQGN HHHHHHCCCCCCCCC	46.30	-
852	N-linked_Glycosylation	DGSSASLNLSKVAGI CCCCCCCCHHHHHHH	39.51	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of GLR1_CAEEL !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GLR1_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GLR1_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GLR1_CAEEL

Related Literatures of Post-Translational Modification