GLPK_RAT - dbPTM
GLPK_RAT - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GLPK_RAT
UniProt AC Q63060
Protein Name Glycerol kinase
Gene Name Gk
Organism Rattus norvegicus (Rat).
Sequence Length 524
Subcellular Localization Mitochondrion outer membrane
Peripheral membrane protein
Cytoplasmic side. Cytoplasm. Bound to the mitochondrial surface or cytoplasmic..
Protein Description Key enzyme in the regulation of glycerol uptake and metabolism (By similarity). Increases the binding of activated glucocorticoid-receptor to nuclei in the presence of ATP..
Protein Sequence MAAAKKAVLGPLVGAVDQGTSSTRFLVFNSKTAELLSHHQVEIKQEFPREGWVEQDPKEILQSVYECIEKTCEKLGQLNIDISNIKAIGVSNQRETTVVWDKLTGEPLYNAVVWLDLRTQSTVEKLSKRIPGNNNFVKSKTGLPLSTYFSAVKLRWLLDNVKKVQEAVEENRALFGTIDSWLIWSLTGGINGGVHCTDVTNASRTMLFNIHSLEWDKELCEFFGIPMEILPNVRSSSEIYGLMKAGALEGVPISGCLGDQSAALVGQMCFQDGQAKNTYGTGCFLLCNTGHKCVFSEHGLLTTVAYKLGRDKPVYYALEGSVAIAGAVIRWLRDNLGIIKSSEEIEKLAKEVGTSYGCYFVPAFSALYAPYWEPSARGIICGLTQFTNKCHIAFAALEAVCFQTREILDAMNRDCGIPLSHLQVDGGMTSNKILMQLQADILYIPVVKPSMPETTALGAAMAAGAAEGVGVWSLEPEDLSAVTMERFEPQINAEESEIRYSTWKKAVMKSIGWVTTQSPESGIP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
20PhosphorylationVGAVDQGTSSTRFLV
CCCCCCCCCCCEEEE		17.5522673903
21PhosphorylationGAVDQGTSSTRFLVF
CCCCCCCCCCEEEEE		36.2122673903
22PhosphorylationAVDQGTSSTRFLVFN
CCCCCCCCCEEEEEC		24.3622673903
23PhosphorylationVDQGTSSTRFLVFNS
CCCCCCCCEEEEECH		25.8022673903
31AcetylationRFLVFNSKTAELLSH
EEEEECHHHHHHHHC		53.5122902405
83PhosphorylationGQLNIDISNIKAIGV
CCCEEEHHCEEEEEE		28.8422673903
125AcetylationRTQSTVEKLSKRIPG
CCHHHHHHHHHCCCC		54.4422902405
125UbiquitinationRTQSTVEKLSKRIPG
CCHHHHHHHHHCCCC		54.44-
162AcetylationRWLLDNVKKVQEAVE
HHHHHHHHHHHHHHH		54.1822902405
163SuccinylationWLLDNVKKVQEAVEE
HHHHHHHHHHHHHHH		44.8826843850
340UbiquitinationRDNLGIIKSSEEIEK
HHHCCCCCCHHHHHH		46.11-
340AcetylationRDNLGIIKSSEEIEK
HHHCCCCCCHHHHHH		46.1122902405
341PhosphorylationDNLGIIKSSEEIEKL
HHCCCCCCHHHHHHH		32.3523991683
342PhosphorylationNLGIIKSSEEIEKLA
HCCCCCCHHHHHHHH		33.9628689409
347AcetylationKSSEEIEKLAKEVGT
CCHHHHHHHHHHHCC		60.4522902405
510PhosphorylationWKKAVMKSIGWVTTQ
HHHHHHHHHCCEECC		14.2925575281
515PhosphorylationMKSIGWVTTQSPESG
HHHHCCEECCCCCCC		16.7725575281
516PhosphorylationKSIGWVTTQSPESGI
HHHCCEECCCCCCCC		19.8925575281
518PhosphorylationIGWVTTQSPESGIP-
HCCEECCCCCCCCC-		28.6625575281
521PhosphorylationVTTQSPESGIP----
EECCCCCCCCC----		45.4625575281
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GLPK_RAT !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GLPK_RAT !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GLPK_RAT !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of GLPK_RAT !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GLPK_RAT

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Related Literatures of Post-Translational Modification

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