GLPK_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GLPK_MOUSE
• UniProt AC: Q64516
• Protein Name: Glycerol kinase
• Gene Name: Gk
• Organism: Mus musculus (Mouse).
• Sequence Length: 559
• Subcellular Localization: Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Bound to the mitochondrial surface or cytoplasmic..
• Protein Description: Key enzyme in the regulation of glycerol uptake and metabolism..
• Protein Sequence: MAAAKKAVLGPLVGAVDQGTSSTRFLVFNSKTAELLSHHQVEIKQEFPREGWVEQDPKEILQSVYECIEKTCEKLGQLNIDISNIKAIGVSNQRETTVVWDKVTGEPLYNAVVWLDLRTQSTVENLSKRIPGNNNFVKSKTGLPLSTYFSAVKLRWLLDNVKKVQEAVEENRALFGTIDSWLIWSLTGGIHGGVHCTDVTNASRTMLFNIHSLEWDKELCEFFGIPMEILPNVRSSSEIYGLMKISHSLKAGALEGVPISGCLGDQSAALVGQMCFQDGQAKNTYGTGCFLLCNTGHKCVFSEHGLLTTVAYKLGRDKPVYYALEGSVAIAGAVIRWLRDNLGIIKSSEEIEKLAKEVGTSYGCYFVPAFSGLYAPYWEPSARGIICGLTQFTNKCHIAFAALEAVCFQTREILDAMNRDCGIPLSHLQVDGGMTSNKILMQLQADILYIPVVKPSMPETTALGAAMAAGAAEGVGVWSLEPEDLSAVTMERFEPQINAEESEIRYSTWKKAVMKSIGWVTTQSPESGDPSIFCSLPLGFFIVSSMVMLIGARYISGIP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Ubiquitination	--MAAAKKAVLGPLV --CHHHHHHHHHHHC	38.71	22790023
20	Phosphorylation	VGAVDQGTSSTRFLV CCCCCCCCCCCEEEE	17.55	29472430
21	Phosphorylation	GAVDQGTSSTRFLVF CCCCCCCCCCEEEEE	36.21	30352176
22	Phosphorylation	AVDQGTSSTRFLVFN CCCCCCCCCEEEEEC	24.36	29472430
23	Phosphorylation	VDQGTSSTRFLVFNS CCCCCCCCEEEEECH	25.80	29472430
31	Ubiquitination	RFLVFNSKTAELLSH EEEEECHHHHHHHHC	53.51	22790023
44	Acetylation	SHHQVEIKQEFPREG HCCCEECHHCCCCCC	30.21	23954790
67	S-palmitoylation	ILQSVYECIEKTCEK HHHHHHHHHHHHHHH	2.39	28526873
74	Ubiquitination	CIEKTCEKLGQLNID HHHHHHHHHCCCEEE	61.13	22790023
83	Phosphorylation	GQLNIDISNIKAIGV CCCEEEHHCEEEEEE	28.84	25195567
86	Ubiquitination	NIDISNIKAIGVSNQ EEEHHCEEEEEECCC	37.90	22790023
128	Ubiquitination	STVENLSKRIPGNNN HHHHHHHHCCCCCCC	58.47	22790023
139	Phosphorylation	GNNNFVKSKTGLPLS CCCCCCCCCCCCCHH	30.10	30482847
140	Ubiquitination	NNNFVKSKTGLPLST CCCCCCCCCCCCHHH	40.68	22790023
293	S-palmitoylation	GTGCFLLCNTGHKCV CCCEEEEECCCCCCE	4.69	26165157
299	S-nitrosylation	LCNTGHKCVFSEHGL EECCCCCCEEECCCH	2.87	22178444
308	Phosphorylation	FSEHGLLTTVAYKLG EECCCHHHHHHHHHC	25.02	22871156
313	Ubiquitination	LLTTVAYKLGRDKPV HHHHHHHHHCCCCCE	34.43	22790023
346	Ubiquitination	RDNLGIIKSSEEIEK HHHCCCCCCHHHHHH	46.11	22790023
347	Phosphorylation	DNLGIIKSSEEIEKL HHCCCCCCHHHHHHH	32.35	29899451
348	Phosphorylation	NLGIIKSSEEIEKLA HCCCCCCHHHHHHHH	33.96	27742792
353	Ubiquitination	KSSEEIEKLAKEVGT CCHHHHHHHHHHHCC	60.45	-
353	Malonylation	KSSEEIEKLAKEVGT CCHHHHHHHHHHHCC	60.45	26320211
353	Acetylation	KSSEEIEKLAKEVGT CCHHHHHHHHHHHCC	60.45	23954790
387	S-palmitoylation	PSARGIICGLTQFTN CCCCCEEEECHHHCC	3.27	28526873
510 (in isoform 1)	Phosphorylation	-	30.83	29472430
511	Acetylation	IRYSTWKKAVMKSIG HCHHHHHHHHHHHHC	37.46	15620127
515 (in isoform 1)	Phosphorylation	-	32.11	29472430
516 (in isoform 1)	Phosphorylation	-	14.29	29472430
518 (in isoform 1)	Phosphorylation	-	21.64	29472430
521 (in isoform 1)	Phosphorylation	-	16.77	29472430

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GLPK_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GLPK_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GLPK_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of GLPK_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.