GLIS3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GLIS3_MOUSE
• UniProt AC: Q6XP49
• Protein Name: Zinc finger protein GLIS3
• Gene Name: Glis3 {ECO:0000312|EMBL:AAP59883.1}
• Organism: Mus musculus (Mouse).
• Sequence Length: 780
• Subcellular Localization: Nucleus .
• Protein Description: Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3'..
• Protein Sequence: MMVQRLGPISPPASQVSTACKQISPSLPRAVNAANLNRPPSDTRSVILQESLVSTTLSLTESQSALSVKQEWSQSYRAFPSLSSSHSSQNGTDLGDLLSLPPGTPVSGNSVSNSLPPYLFGMENSHSPYPSPRHSATRAHSTRSKKRALSLSPLSDGIGIDFNTIIRTSPTSLVAYINGPRASPANLSPQSEVYGHFLGVRGSCIPQSCAVASGQKGILVASGGHTLPGYGEDGTLEYERMQQLEHGGLQPGPVNNMVLQPGLPGQDGQTANMLKTERLEEFPASALDLPSALPLPLPPPQGPPPPYHAHPHLHHPELLPHTQSLSLAQTGLEEDGEMEDSGGKHCCRWIDCSALYDQQEELVRHIEKVHIDQRKGEDFTCFWTGCPRRYKPFNARYKLLIHMRVHSGEKPNKCTFEGCKKAFSRLENLKIHLRSHTGEKPYLCQHPGCQKAFSNSSDRAKHQRTHLDTKPYACQIPGCTKRYTDPSSLRKHVKAHSSREQQARKKLRSSTELHPDLLTDCLAVQPLQPATSPGDAADHTVGHSPGPGPGPGPGAELYSAPIFASNHSTRSGTAAGAGPPPHPVSHPSPGHNVQGSPHNPSSQLPPLTAVDAGAERFAPPTPSPHHISPGRVPAPPSLLQRAQAPHSQQPPGSLLKPYQPETNSSFQPNGIHVHGFYGQLQTFCPPHYPDSQRTVPPSGSCSMVPSFEDCLVPTSMGQAGFDVFHRAFSTHSGITVYDLPSASSSLFGESLRSGPEDPTFLQLSAVDRCPSQLSSVYTEG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	VQRLGPISPPASQVS CCCCCCCCCCHHHHH	28.15	26239621
24	Phosphorylation	STACKQISPSLPRAV HHHHHHHCCCCCCHH	13.12	26824392
41	Phosphorylation	ANLNRPPSDTRSVIL HHCCCCCCCCCHHHH	55.06	29550500
43	Phosphorylation	LNRPPSDTRSVILQE CCCCCCCCCHHHHHH	29.22	29550500
124 (in isoform 2)	Phosphorylation	-	35.81	29514104
150	Phosphorylation	RSKKRALSLSPLSDG CCHHCCCCCCCCCCC	26.30	-
152	Phosphorylation	KKRALSLSPLSDGIG HHCCCCCCCCCCCCC	22.03	-
155	Phosphorylation	ALSLSPLSDGIGIDF CCCCCCCCCCCCCCH	36.86	-
165 (in isoform 2)	Phosphorylation	-	1.79	29514104
168	Phosphorylation	DFNTIIRTSPTSLVA CHHHEEECCCCCEEE	28.75	22817900
169	Phosphorylation	FNTIIRTSPTSLVAY HHHEEECCCCCEEEE	19.14	21082442
183	Phosphorylation	YINGPRASPANLSPQ EECCCCCCCCCCCCC	26.31	23984901
188	Phosphorylation	RASPANLSPQSEVYG CCCCCCCCCCHHHHC	22.24	26824392
191	Phosphorylation	PANLSPQSEVYGHFL CCCCCCCHHHHCHHH	32.20	23984901
194	Phosphorylation	LSPQSEVYGHFLGVR CCCCHHHHCHHHCCC	10.79	23984901
585	Phosphorylation	GPPPHPVSHPSPGHN CCCCCCCCCCCCCCC	33.85	25338131
621	Phosphorylation	AERFAPPTPSPHHIS CCCCCCCCCCCCCCC	35.03	26370283
623	Phosphorylation	RFAPPTPSPHHISPG CCCCCCCCCCCCCCC	39.07	26370283
628	Phosphorylation	TPSPHHISPGRVPAP CCCCCCCCCCCCCCC	19.56	29514104

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GLIS3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GLIS3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GLIS3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SUFU_HUMAN	SUFU	physical	21543335

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.