GLI4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GLI4_HUMAN
• UniProt AC: P10075
• Protein Name: Zinc finger protein GLI4
• Gene Name: GLI4
• Organism: Homo sapiens (Human).
• Sequence Length: 376
• Subcellular Localization: Nucleus .
• Protein Sequence: MAALGDIQESPSVPSPVSLSSPGTPGTQHHEPQLHLHGHQHGSPGSSPKVLSQPSDLDLQDVEEVEIGRDTFWPDSEPKPEQAPRSPGSQAPDEGAGGALRSLLRSLPRRARCSAGFGPESSAERPAGQPPGAVPCAQPRGAWRVTLVQQAAAGPEGAPERAAELGVNFGRSRQGSARGAKPHRCEACGKSFKYNSLLLKHQRIHTGEKPYACHECGKRFRGWSGFIQHHRIHTGEKPYECGQCGRAFSHSSHFTQHLRIHNGEKPYKCGECGQAFSQSSNLVRHQRLHTGEKPYACSQCGKAFIWSSVLIEHQRIHTGEKPYECSDCGKAFRGRSHFFRHLRTHTGEKPFACGACGKAFGQSSQLIQHQRVHYRE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
86	Phosphorylation	KPEQAPRSPGSQAPD CCCCCCCCCCCCCCC	32.33	29255136
89	Phosphorylation	QAPRSPGSQAPDEGA CCCCCCCCCCCCCCH	26.93	23927012
102	Phosphorylation	GAGGALRSLLRSLPR CHHHHHHHHHHHCCH	32.38	28674151
106	Phosphorylation	ALRSLLRSLPRRARC HHHHHHHHCCHHHHC	42.57	28674151
125	Dimethylation	GPESSAERPAGQPPG CCCCCCCCCCCCCCC	26.53	-
140	Dimethylation	AVPCAQPRGAWRVTL CCCCCCCCCCEEEEE	35.07	-
206	Phosphorylation	LKHQRIHTGEKPYAC HHCCCCCCCCCCEEE	44.67	28111955
234	Phosphorylation	IQHHRIHTGEKPYEC CCCCCEECCCCCCCC	44.67	28111955
280	Phosphorylation	GQAFSQSSNLVRHQR CCCHHHCCCHHHHCC	26.92	24719451
290	Phosphorylation	VRHQRLHTGEKPYAC HHHCCCCCCCCCEEH	52.18	21857030
318	Phosphorylation	IEHQRIHTGEKPYEC EEECCCCCCCCCEEC	44.67	21712546
321	Ubiquitination	QRIHTGEKPYECSDC CCCCCCCCCEECCCC	55.00	-
330	Ubiquitination	YECSDCGKAFRGRSH EECCCCCHHHCCCCH	51.16	-
344	Phosphorylation	HFFRHLRTHTGEKPF HHHHHHHHCCCCCCC	30.10	-
346	Phosphorylation	FRHLRTHTGEKPFAC HHHHHHCCCCCCCCC	46.56	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GLI4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GLI4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GLI4_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of GLI4_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86, AND MASSSPECTROMETRY.
PubMed: 19690332

"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86, AND MASSSPECTROMETRY.
PubMed: 19369195

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86, AND MASSSPECTROMETRY.
PubMed: 19413330

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86, AND MASSSPECTROMETRY.
PubMed: 18669648

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86, AND MASSSPECTROMETRY.
PubMed: 18691976

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86, AND MASSSPECTROMETRY.
PubMed: 17081983