GIT1_RAT - dbPTM
GIT1_RAT - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GIT1_RAT
UniProt AC Q9Z272
Protein Name ARF GTPase-activating protein GIT1
Gene Name Git1
Organism Rattus norvegicus (Rat).
Sequence Length 770
Subcellular Localization Cytoplasm. Cycles between at least 3 distinct intracellular compartments, including focal adhesions, cytoplasmic complexes and membrane protrusions. During cell migration, when cells detach, moves from the adhesions into the cytoplasmic complexes tow
Protein Description GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine-phosphorylated paxillin in cytoplasmic complexes. Involved in the regulation of cytokinesis; the function may involve SDCCAG3 and PTPN13 (By similarity)..
Protein Sequence MSRKGPRAEVCADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLASNGANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGTTPLHVAAKAGQTLQAELLVVYGADPGSPDVNGRTPIDYARQAGHHELAERLVECQYELTDRLAFYLCGRKPDHKNGHYIIPQMADRSRQKCMSQSLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRRENDAVWLATQNHSTLVTERSAVPFLPVNPEYSATRNQGRQKLARFNAREFATLIIDILSEAKRRQQGKSLSSPTDNLELSARNQSDLDDQHDYDSVASDEDTDQEPLPSAGATRNNRARSMDSSDLSDGAVTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRKLQREIHKLQAENLQLRQPPGPVPVPSLPSERAEHTLMGPGGSTHRRDRQAFSMYEPGSALKPFGGAPGDELATRLQPFHSTELEDDAIYSVHVPAGLYRIRKGVSASSVTFTPSSPLLSSSQEGSRHASKLSRHGSGAESDYENTQSGEPLLGLEGKRFLELSKEDELHAELESLDGDPDPGLPSTEDVILKTEQVTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLFPKRPALEPVRSSLRLLNASAYRLQSECRKTVPPEPGAPVDFQLLTQQVIQCAYDIAKAAKQLVTITTREKKQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
49AcetylationGRHISIVKHLRHSAW
HHHHHHHHHHHHCCC		34.9422902405
134PhosphorylationGVTAKDLSKQLHSSV
CCCHHHHHHHHHHHH		28.6123800682
139PhosphorylationDLSKQLHSSVRTGNL
HHHHHHHHHHHHCCH		38.8423800682
224PhosphorylationERLVECQYELTDRLA
HHHHHHHHHHHHHHH		25.27-
293PhosphorylationEELAMDVYDEVDRRE
HHHHHHHHHHHHHHH		11.34-
368PhosphorylationKRRQQGKSLSSPTDN
HHHHCCCCCCCCCCC		40.0627097102
370PhosphorylationRQQGKSLSSPTDNLE
HHCCCCCCCCCCCHH		41.1727097102
371PhosphorylationQQGKSLSSPTDNLEL
HCCCCCCCCCCCHHH		36.7928689409
373PhosphorylationGKSLSSPTDNLELSA
CCCCCCCCCCHHHHH		39.1927097102
379PhosphorylationPTDNLELSARNQSDL
CCCCHHHHHCCCHHC		18.79-
384PhosphorylationELSARNQSDLDDQHD
HHHHCCCHHCCCCCC		43.6328551015
392PhosphorylationDLDDQHDYDSVASDE
HCCCCCCHHHCCCCC		14.1621890632
394PhosphorylationDDQHDYDSVASDEDT
CCCCCHHHCCCCCCC		17.2223298284
397PhosphorylationHDYDSVASDEDTDQE
CCHHHCCCCCCCCCC		39.1023712012
401PhosphorylationSVASDEDTDQEPLPS
HCCCCCCCCCCCCCC		37.2223298284
408PhosphorylationTDQEPLPSAGATRNN
CCCCCCCCCCCCCCC		47.2028689409
412PhosphorylationPLPSAGATRNNRARS
CCCCCCCCCCCCCCC		32.7728689409
419PhosphorylationTRNNRARSMDSSDLS
CCCCCCCCCCHHHCC		26.4223589303
422PhosphorylationNRARSMDSSDLSDGA
CCCCCCCHHHCCCCC		19.6727097102
423PhosphorylationRARSMDSSDLSDGAV
CCCCCCHHHCCCCCE		38.0027097102
426PhosphorylationSMDSSDLSDGAVTLQ
CCCHHHCCCCCEEHH		38.7027097102
431PhosphorylationDLSDGAVTLQEYLEL
HCCCCCEEHHHHHHH		23.3822673903
457PhosphorylationQQLMKVNSSLSDELR
HHHHHHCCHHHHHHH		35.3325575281
458PhosphorylationQLMKVNSSLSDELRK
HHHHHCCHHHHHHHH		27.0425575281
460PhosphorylationMKVNSSLSDELRKLQ
HHHCCHHHHHHHHHH		30.8725575281
500PhosphorylationPSERAEHTLMGPGGS
CCHHCCCCCCCCCCC		15.2225575281
507PhosphorylationTLMGPGGSTHRRDRQ
CCCCCCCCCCCCCCC		27.2727097102
508PhosphorylationLMGPGGSTHRRDRQA
CCCCCCCCCCCCCCC		23.7627097102
517PhosphorylationRRDRQAFSMYEPGSA
CCCCCCCCCCCCCCC		24.3830181290
519PhosphorylationDRQAFSMYEPGSALK
CCCCCCCCCCCCCCC		20.1321890632
523PhosphorylationFSMYEPGSALKPFGG
CCCCCCCCCCCCCCC		40.9430181290
526UbiquitinationYEPGSALKPFGGAPG
CCCCCCCCCCCCCCC		37.71-
545PhosphorylationTRLQPFHSTELEDDA
HHCCCCCCCCCCCCC		24.7728432305
546PhosphorylationRLQPFHSTELEDDAI
HCCCCCCCCCCCCCE		35.7027097102
554PhosphorylationELEDDAIYSVHVPAG
CCCCCCEEEEEECCC		13.3221890632
555PhosphorylationLEDDAIYSVHVPAGL
CCCCCEEEEEECCCH		10.3023984901
563PhosphorylationVHVPAGLYRIRKGVS
EEECCCHHHCCCCCC		11.7727097102
570PhosphorylationYRIRKGVSASSVTFT
HHCCCCCCCCCEEEC		30.9727097102
572PhosphorylationIRKGVSASSVTFTPS
CCCCCCCCCEEECCC		20.1727097102
573PhosphorylationRKGVSASSVTFTPSS
CCCCCCCCEEECCCC		25.5427097102
575PhosphorylationGVSASSVTFTPSSPL
CCCCCCEEECCCCCC		24.6027097102
577PhosphorylationSASSVTFTPSSPLLS
CCCCEEECCCCCCCC		16.9427097102
579PhosphorylationSSVTFTPSSPLLSSS
CCEEECCCCCCCCCC		41.3427097102
580PhosphorylationSVTFTPSSPLLSSSQ
CEEECCCCCCCCCCC		22.2927097102
584PhosphorylationTPSSPLLSSSQEGSR
CCCCCCCCCCCCHHH		35.3127097102
585PhosphorylationPSSPLLSSSQEGSRH
CCCCCCCCCCCHHHH		35.6927097102
586PhosphorylationSSPLLSSSQEGSRHA
CCCCCCCCCCHHHHH		28.9527097102
590PhosphorylationLSSSQEGSRHASKLS
CCCCCCHHHHHHHHH		21.8227097102
597PhosphorylationSRHASKLSRHGSGAE
HHHHHHHHHCCCCCC		26.4323984901
601PhosphorylationSKLSRHGSGAESDYE
HHHHHCCCCCCCCCC		28.8023712012
605PhosphorylationRHGSGAESDYENTQS
HCCCCCCCCCCCCCC		44.9830411139
607PhosphorylationGSGAESDYENTQSGE
CCCCCCCCCCCCCCC		21.9923712012
610PhosphorylationAESDYENTQSGEPLL
CCCCCCCCCCCCCCC		16.5127097102
612PhosphorylationSDYENTQSGEPLLGL
CCCCCCCCCCCCCCC		42.9827097102
628PhosphorylationGKRFLELSKEDELHA
CHHHHHCCCHHHHHH		25.3222673903
639PhosphorylationELHAELESLDGDPDP
HHHHHHHHCCCCCCC		44.3729779826
679PhosphorylationAQEFKHDSFVPCSEK
HHHHCCCCCCCCHHH		28.0625575281
684PhosphorylationHDSFVPCSEKIHLAV
CCCCCCCHHHHHHHH		35.5425575281
709PhosphorylationPALEPVRSSLRLLNA
CCCHHHHHHHHHHCH		33.6822673903
710PhosphorylationALEPVRSSLRLLNAS
CCHHHHHHHHHHCHH		13.6222673903
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
293YPhosphorylationKinaseSRCQ9WUD9
PSP
554YPhosphorylationKinaseSRCQ9WUD9
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GIT1_RAT !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GIT1_RAT !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TGFI1_HUMANTGFB1I1physical
12153727
PAXI_HUMANPXNphysical
12153727
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GIT1_RAT

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Related Literatures of Post-Translational Modification

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