UniProt ID | GIMA1_HUMAN | |
---|---|---|
UniProt AC | Q8WWP7 | |
Protein Name | GTPase IMAP family member 1 | |
Gene Name | GIMAP1 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 306 | |
Subcellular Localization |
Endoplasmic reticulum membrane Single-pass type IV membrane protein. Golgi apparatus membrane. Golgi apparatus . |
|
Protein Description | May regulate lymphocyte survival. Required for normal levels of mature T-lymphocytes and mature B-cells (By similarity).. | |
Protein Sequence | MGGRKMATDEENVYGLEENAQSRQESTRRLILVGRTGAGKSATGNSILGQRRFFSRLGATSVTRACTTGSRRWDKCHVEVVDTPDIFSSQVSKTDPGCEERGHCYLLSAPGPHALLLVTQLGRFTAQDQQAVRQVRDMFGEDVLKWMVIVFTRKEDLAGGSLHDYVSNTENRALRELVAECGGRVCAFDNRATGREQEAQVEQLLGMVEGLVLEHKGAHYSNEVYELAQVLRWAGPEERLRRVAERVAARVQRRPWGAWLSARLWKWLKSPRSWRLGLALLLGGALLFWVLLHRRWSEAVAEVGPD | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
5 | Ubiquitination | ---MGGRKMATDEEN ---CCCCCCCCCHHH | 35.84 | - | |
8 | Phosphorylation | MGGRKMATDEENVYG CCCCCCCCCHHHCCC | 40.21 | 26552605 | |
14 | Phosphorylation | ATDEENVYGLEENAQ CCCHHHCCCCHHHHH | 27.81 | 28796482 | |
22 | Phosphorylation | GLEENAQSRQESTRR CCHHHHHHHHHHHCE | 33.26 | 26552605 | |
40 | Ubiquitination | VGRTGAGKSATGNSI EECCCCCCCCCCCCH | 36.06 | - | |
46 | Phosphorylation | GKSATGNSILGQRRF CCCCCCCCHHCCHHH | 22.12 | 24719451 | |
61 | Phosphorylation | FSRLGATSVTRACTT HHHCCCCEEEHHCCC | 22.43 | 28857561 | |
63 | Phosphorylation | RLGATSVTRACTTGS HCCCCEEEHHCCCCC | 16.59 | 22210691 | |
68 | Phosphorylation | SVTRACTTGSRRWDK EEEHHCCCCCCCCCC | 32.80 | 22210691 | |
70 | Phosphorylation | TRACTTGSRRWDKCH EHHCCCCCCCCCCCE | 19.31 | 22210691 | |
75 | Ubiquitination | TGSRRWDKCHVEVVD CCCCCCCCCEEEEEC | 21.20 | - | |
93 | Ubiquitination | IFSSQVSKTDPGCEE HHHHCCCCCCCCCCC | 59.08 | - | |
138 | Sulfoxidation | AVRQVRDMFGEDVLK HHHHHHHHHHHHHHH | 3.05 | 21406390 | |
154 | Ubiquitination | MVIVFTRKEDLAGGS EEEEEECHHHHCCCC | 53.15 | - | |
167 | Phosphorylation | GSLHDYVSNTENRAL CCHHHHHCCHHCHHH | 31.63 | - | |
169 | Phosphorylation | LHDYVSNTENRALRE HHHHHCCHHCHHHHH | 27.42 | - | |
225 | Phosphorylation | AHYSNEVYELAQVLR CCCCHHHHHHHHHHH | 10.07 | 27642862 | |
273 | Phosphorylation | KWLKSPRSWRLGLAL HHHCCCCHHHHHHHH | 21.67 | 24719451 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GIMA1_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GIMA1_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GIMA1_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
MINP1_HUMAN | MINPP1 | physical | 28514442 | |
CYTS_HUMAN | CST4 | physical | 28514442 |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
There are no disease associations of PTM sites. | ||||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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