| UniProt ID | GIMA1_HUMAN | |
|---|---|---|
| UniProt AC | Q8WWP7 | |
| Protein Name | GTPase IMAP family member 1 | |
| Gene Name | GIMAP1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 306 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Single-pass type IV membrane protein. Golgi apparatus membrane. Golgi apparatus . |
|
| Protein Description | May regulate lymphocyte survival. Required for normal levels of mature T-lymphocytes and mature B-cells (By similarity).. | |
| Protein Sequence | MGGRKMATDEENVYGLEENAQSRQESTRRLILVGRTGAGKSATGNSILGQRRFFSRLGATSVTRACTTGSRRWDKCHVEVVDTPDIFSSQVSKTDPGCEERGHCYLLSAPGPHALLLVTQLGRFTAQDQQAVRQVRDMFGEDVLKWMVIVFTRKEDLAGGSLHDYVSNTENRALRELVAECGGRVCAFDNRATGREQEAQVEQLLGMVEGLVLEHKGAHYSNEVYELAQVLRWAGPEERLRRVAERVAARVQRRPWGAWLSARLWKWLKSPRSWRLGLALLLGGALLFWVLLHRRWSEAVAEVGPD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 5 | Ubiquitination | ---MGGRKMATDEEN ---CCCCCCCCCHHH | 35.84 | - | |
| 8 | Phosphorylation | MGGRKMATDEENVYG CCCCCCCCCHHHCCC | 40.21 | 26552605 | |
| 14 | Phosphorylation | ATDEENVYGLEENAQ CCCHHHCCCCHHHHH | 27.81 | 28796482 | |
| 22 | Phosphorylation | GLEENAQSRQESTRR CCHHHHHHHHHHHCE | 33.26 | 26552605 | |
| 40 | Ubiquitination | VGRTGAGKSATGNSI EECCCCCCCCCCCCH | 36.06 | - | |
| 46 | Phosphorylation | GKSATGNSILGQRRF CCCCCCCCHHCCHHH | 22.12 | 24719451 | |
| 61 | Phosphorylation | FSRLGATSVTRACTT HHHCCCCEEEHHCCC | 22.43 | 28857561 | |
| 63 | Phosphorylation | RLGATSVTRACTTGS HCCCCEEEHHCCCCC | 16.59 | 22210691 | |
| 68 | Phosphorylation | SVTRACTTGSRRWDK EEEHHCCCCCCCCCC | 32.80 | 22210691 | |
| 70 | Phosphorylation | TRACTTGSRRWDKCH EHHCCCCCCCCCCCE | 19.31 | 22210691 | |
| 75 | Ubiquitination | TGSRRWDKCHVEVVD CCCCCCCCCEEEEEC | 21.20 | - | |
| 93 | Ubiquitination | IFSSQVSKTDPGCEE HHHHCCCCCCCCCCC | 59.08 | - | |
| 138 | Sulfoxidation | AVRQVRDMFGEDVLK HHHHHHHHHHHHHHH | 3.05 | 21406390 | |
| 154 | Ubiquitination | MVIVFTRKEDLAGGS EEEEEECHHHHCCCC | 53.15 | - | |
| 167 | Phosphorylation | GSLHDYVSNTENRAL CCHHHHHCCHHCHHH | 31.63 | - | |
| 169 | Phosphorylation | LHDYVSNTENRALRE HHHHHCCHHCHHHHH | 27.42 | - | |
| 225 | Phosphorylation | AHYSNEVYELAQVLR CCCCHHHHHHHHHHH | 10.07 | 27642862 | |
| 273 | Phosphorylation | KWLKSPRSWRLGLAL HHHCCCCHHHHHHHH | 21.67 | 24719451 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GIMA1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GIMA1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GIMA1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| MINP1_HUMAN | MINPP1 | physical | 28514442 | |
| CYTS_HUMAN | CST4 | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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