GIMA1_HUMAN - dbPTM
GIMA1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GIMA1_HUMAN
UniProt AC Q8WWP7
Protein Name GTPase IMAP family member 1
Gene Name GIMAP1
Organism Homo sapiens (Human).
Sequence Length 306
Subcellular Localization Endoplasmic reticulum membrane
Single-pass type IV membrane protein. Golgi apparatus membrane. Golgi apparatus .
Protein Description May regulate lymphocyte survival. Required for normal levels of mature T-lymphocytes and mature B-cells (By similarity)..
Protein Sequence MGGRKMATDEENVYGLEENAQSRQESTRRLILVGRTGAGKSATGNSILGQRRFFSRLGATSVTRACTTGSRRWDKCHVEVVDTPDIFSSQVSKTDPGCEERGHCYLLSAPGPHALLLVTQLGRFTAQDQQAVRQVRDMFGEDVLKWMVIVFTRKEDLAGGSLHDYVSNTENRALRELVAECGGRVCAFDNRATGREQEAQVEQLLGMVEGLVLEHKGAHYSNEVYELAQVLRWAGPEERLRRVAERVAARVQRRPWGAWLSARLWKWLKSPRSWRLGLALLLGGALLFWVLLHRRWSEAVAEVGPD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
5Ubiquitination---MGGRKMATDEEN
---CCCCCCCCCHHH
35.84-
8PhosphorylationMGGRKMATDEENVYG
CCCCCCCCCHHHCCC
40.2126552605
14PhosphorylationATDEENVYGLEENAQ
CCCHHHCCCCHHHHH
27.8128796482
22PhosphorylationGLEENAQSRQESTRR
CCHHHHHHHHHHHCE
33.2626552605
40UbiquitinationVGRTGAGKSATGNSI
EECCCCCCCCCCCCH
36.06-
46PhosphorylationGKSATGNSILGQRRF
CCCCCCCCHHCCHHH
22.1224719451
61PhosphorylationFSRLGATSVTRACTT
HHHCCCCEEEHHCCC
22.4328857561
63PhosphorylationRLGATSVTRACTTGS
HCCCCEEEHHCCCCC
16.5922210691
68PhosphorylationSVTRACTTGSRRWDK
EEEHHCCCCCCCCCC
32.8022210691
70PhosphorylationTRACTTGSRRWDKCH
EHHCCCCCCCCCCCE
19.3122210691
75UbiquitinationTGSRRWDKCHVEVVD
CCCCCCCCCEEEEEC
21.20-
93UbiquitinationIFSSQVSKTDPGCEE
HHHHCCCCCCCCCCC
59.08-
138SulfoxidationAVRQVRDMFGEDVLK
HHHHHHHHHHHHHHH
3.0521406390
154UbiquitinationMVIVFTRKEDLAGGS
EEEEEECHHHHCCCC
53.15-
167PhosphorylationGSLHDYVSNTENRAL
CCHHHHHCCHHCHHH
31.63-
169PhosphorylationLHDYVSNTENRALRE
HHHHHCCHHCHHHHH
27.42-
225PhosphorylationAHYSNEVYELAQVLR
CCCCHHHHHHHHHHH
10.0727642862
273PhosphorylationKWLKSPRSWRLGLAL
HHHCCCCHHHHHHHH
21.6724719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GIMA1_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GIMA1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GIMA1_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MINP1_HUMANMINPP1physical
28514442
CYTS_HUMANCST4physical
28514442

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GIMA1_HUMAN

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Related Literatures of Post-Translational Modification

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