GGT7_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GGT7_RAT
• UniProt AC: Q99MZ4
• Protein Name: Glutathione hydrolase 7
• Gene Name: Ggt7
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 662
• Subcellular Localization: Membrane; Single-pass type II membrane protein.
• Protein Description: Cleaves glutathione conjugates..
• Protein Sequence: MAAENEASQESALGAYSPVDYMSITSFPRLPEDEPAPAAPLRGRKDEDAFLGDPDTDPDSFLKSARLQRLPSSSSEMGSQDGSPLRETRKDPFSAAAAECSCRQDGLTVIVTACLTFATGVTVALVMQIYFGDPQIFQQGAVVTDASCCTALGMEVLSKQGSSVDAAVAAALCLGIVAPHSSGLGGGGVMLVHDIRRNESHLIDFRESAPGALREEALQRSWDTKPGLLVGVPGMVKGLYEAHQLYGRLPWSQVLAFAAAVAQDGFNVTHDLAHALAEQLPPNASDRFLETFLPLGHPPLPGSLLRRPDLAEVLDILGISGPAAFYNGGNLTLEMVAEVQHAGGVMTEEDFSNYSALTEKPVCGVYRGHLVLSPPPPHTGPALISALNILEGFNLTSLVSREQALHWVAETLKIALALASRLGDPVYDSTISESMDDMLSKVEAANFRGHISDSQAAPAPLLPVYELDGAPTAAQVLVMGPDDFIVAMVSSLNRPFGSGLLTPSGILLNSQMLDFSWPNRTANHSAPSLENSVQPGKRPLSFLLPTVVRPAEGLCGTYLALGANGAARGLSGLTQVLLNVLTLNRNLSDSLARGRLHPDLQSNVLQVDSEFTEEEIEFLEARGHHVEKVDVLSWVHGSRRTNNFIIGVKDPRSLDATGASIL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	ESALGAYSPVDYMSI HHHCCCCCCCCCEEC	20.22	30240740
45	Ubiquitination	AAPLRGRKDEDAFLG CCCCCCCCCCCCCCC	69.19	-
56	Phosphorylation	AFLGDPDTDPDSFLK CCCCCCCCCHHHHHH	55.61	28432305
60	Phosphorylation	DPDTDPDSFLKSARL CCCCCHHHHHHHHHH	37.56	28432305
72	Phosphorylation	ARLQRLPSSSSEMGS HHHHCCCCCCHHCCC	47.66	27097102
73	Phosphorylation	RLQRLPSSSSEMGSQ HHHCCCCCCHHCCCC	35.62	27097102
74	Phosphorylation	LQRLPSSSSEMGSQD HHCCCCCCHHCCCCC	34.35	27097102
75	Phosphorylation	QRLPSSSSEMGSQDG HCCCCCCHHCCCCCC	33.28	27097102
79	Phosphorylation	SSSSEMGSQDGSPLR CCCHHCCCCCCCCCC	24.64	27097102
83	Phosphorylation	EMGSQDGSPLRETRK HCCCCCCCCCCCCCC	29.11	27097102
198	N-linked_Glycosylation	LVHDIRRNESHLIDF EEEECCCCCCCEEEH	45.32	-
267	N-linked_Glycosylation	AVAQDGFNVTHDLAH HHHCCCCCCHHHHHH	43.22	-
283	N-linked_Glycosylation	LAEQLPPNASDRFLE HHHHCCCCHHHHHHH	50.57	-
330	N-linked_Glycosylation	AAFYNGGNLTLEMVA EEEECCCCEEEEEEE	31.11	-
353	N-linked_Glycosylation	MTEEDFSNYSALTEK CCHHHHCCCHHCCCC	34.47	-
394	N-linked_Glycosylation	LNILEGFNLTSLVSR HHHHHCCCCHHHCCH	53.95	-
519	N-linked_Glycosylation	MLDFSWPNRTANHSA CCCCCCCCCCCCCCC	47.91	-
523	N-linked_Glycosylation	SWPNRTANHSAPSLE CCCCCCCCCCCCCHH	29.09	24090084
586	N-linked_Glycosylation	NVLTLNRNLSDSLAR HHHHHCCCHHHHHHH	42.71	24090084

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GGT7_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GGT7_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GGT7_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of GGT7_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.