| UniProt ID | GGA1_MOUSE | |
|---|---|---|
| UniProt AC | Q8R0H9 | |
| Protein Name | ADP-ribosylation factor-binding protein GGA1 | |
| Gene Name | Gga1 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 635 | |
| Subcellular Localization |
Golgi apparatus, trans-Golgi network membrane Peripheral membrane protein. Endosome membrane Peripheral membrane protein. |
|
| Protein Description | Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif (By similarity).. | |
| Protein Sequence | MEPAMEPETLEARINRATNPLNKELNWASINSFCEQLNEDFEGPPLATRLLAHKIQSPQEWEAIQALTVLETCMKSCGKRFHDEVGKFRFLNELIKVVSPKYLGSRTSEKVKSKILELLYSWTVCLPEEVKIAEAYQMLKKQGIVKSDPKLPEDAIFPLPPPRPKNVIFEDEEKSKMLARLLKSSHPEDLRAANKLIKEMVQEDQKRMEKISKRVNAIEEVNNNVKLLTEMVMSHSQGAASSSSEDLMKELYQRCERMRPTLFRLASDTEDNDEALAEILQANDNLTQVINLYKQLVRGEEVNGDATASSIPGSTSALLDLSGLDLPPPGTTQPATPTRPGNQSSPEQLSASVSLLDDELMSLGLSDPTPPSGTSSDSVGWDNFQSSDGTESSVPPPAQAPSMDCRPPAQAPPPTSSGLDDLDLLGKTLMQQALPPEAQQVRWEKQQPAPRLTLRDLQSKSSSPSPGAASLLHTTSPEPPGPPPQATPTEFSLTSITVPLESIKPSSILPVTVYDQHGFRVLFHFARDPLPGRSDVLVVVVSMLSTAPQPIRNIVFQSAVPKVMKVRLQPPSGTELPAFNPIVHPSAITQVLLLANPQKEKVRLRYKLIFTMGDQTYNEMGDVDQFPPPETWGSL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Acetylation | -------MEPAMEPE -------CCCCCCHH | 14.54 | - | |
| 23 | Ubiquitination | RATNPLNKELNWASI HHCCHHHHHCCHHHH | 71.86 | - | |
| 101 | Malonylation | LIKVVSPKYLGSRTS HHHHHCHHHCCCCCC | 45.67 | 26320211 | |
| 101 | Ubiquitination | LIKVVSPKYLGSRTS HHHHHCHHHCCCCCC | 45.67 | - | |
| 174 | Ubiquitination | VIFEDEEKSKMLARL CCCCCHHHHHHHHHH | 54.02 | 22790023 | |
| 183 | Ubiquitination | KMLARLLKSSHPEDL HHHHHHHHCCCHHHH | 55.28 | 22790023 | |
| 184 | Phosphorylation | MLARLLKSSHPEDLR HHHHHHHCCCHHHHH | 33.57 | 29176673 | |
| 185 | Phosphorylation | LARLLKSSHPEDLRA HHHHHHCCCHHHHHH | 41.28 | 29176673 | |
| 198 | Ubiquitination | RAANKLIKEMVQEDQ HHHHHHHHHHHHHHH | 50.63 | 22790023 | |
| 206 | Ubiquitination | EMVQEDQKRMEKISK HHHHHHHHHHHHHHH | 67.06 | 27667366 | |
| 267 | Phosphorylation | PTLFRLASDTEDNDE HHHHHHHCCCCCCHH | 50.05 | 23737553 | |
| 269 | Phosphorylation | LFRLASDTEDNDEAL HHHHHCCCCCCHHHH | 42.62 | 23737553 | |
| 354 | Phosphorylation | EQLSASVSLLDDELM HHHHHHEEHHCHHHH | 22.25 | - | |
| 417 | Phosphorylation | QAPPPTSSGLDDLDL CCCCCCCCCCCHHHH | 45.94 | - | |
| 445 | Malonylation | AQQVRWEKQQPAPRL HHHHHHHHCCCCCCE | 47.47 | 26320211 | |
| 445 | Ubiquitination | AQQVRWEKQQPAPRL HHHHHHHHCCCCCCE | 47.47 | 27667366 | |
| 451 | Dimethylation | EKQQPAPRLTLRDLQ HHCCCCCCEEHHHHH | 42.27 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GGA1_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GGA1_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GGA1_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of GGA1_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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