| UniProt ID | GFPT1_RAT | |
|---|---|---|
| UniProt AC | P82808 | |
| Protein Name | Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 | |
| Gene Name | Gfpt1 | |
| Organism | Rattus norvegicus (Rat). | |
| Sequence Length | 681 | |
| Subcellular Localization | ||
| Protein Description | Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. Regulates the circadian expression of clock genes ARNTL/BMAL1 and CRY1.. | |
| Protein Sequence | MCGIFAYLNYHVPRTRREILETLIKGLQRLEYRGYDSAGVGLDGGNDKDWEANACKIQLIKKKGKVKALDEEVHKQQDMDLDIEFDVHLGIAHTRWATHGEPSPVNSHPQRSDKNNEFIVIHNGIITNYKDLKKFLESKGYDFESETDTETIAKLVKYMYDNWESQDVSFTTLVERVIQQLEGAFALVFKSVHFPGQAVGTRRGSPLLIGVRSEHKLSTDHIPILYRTGKDKKGSCGLSRVDSTTCLFPVEEKAVEYYFASDASAVIEHTNRVIFLEDDDVAAVVDGRLSIHRIKRTARDHPGRAVQTLQMELQQIMKGNFSSFMQKEIFEQPESVVNTMRGRVNFDDYTVNLGGLKDHIKEIQRCRRLILIACGTSYHAGMATRQVLEELTELPVMVELASDFLDRNTPVFRDDVCFFISQSGETADTLMGLRYCKERGALTVGITNTVGSSISRETDCGVHINAGPEIGVASTKAYTSQFVSLVMFALMMCDDRISMQERRKEIMLGLKRLPDLIKEVLSMDDEIQKLATELYHQKSVLIMGRGYHYATCLEGALKIKEITYMHSEGILAGELKHGPLALVDKLMPVIMIIMRDHTYAKCQNALQQVVARQGRPVVICDKEDTETIKNTKRTIKVPHSVDCLQGILSVIPLQLLAFHLAVLRGYDVDFPRNLAKSVTVE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 48 | Ubiquitination | GLDGGNDKDWEANAC CCCCCCCCCHHHHHH | 69.60 | - | |
| 103 | Phosphorylation | WATHGEPSPVNSHPQ CCCCCCCCCCCCCCC | 36.86 | - | |
| 205 | Phosphorylation | AVGTRRGSPLLIGVR CCCCCCCCCEEEEEE | 15.57 | 23984901 | |
| 235 | Phosphorylation | TGKDKKGSCGLSRVD CCCCCCCCCCCCCCC | 17.56 | 25575281 | |
| 239 | Phosphorylation | KKGSCGLSRVDSTTC CCCCCCCCCCCCCCE | 18.62 | 25575281 | |
| 243 | Phosphorylation | CGLSRVDSTTCLFPV CCCCCCCCCCEEEEC | 23.82 | 23712012 | |
| 244 | Phosphorylation | GLSRVDSTTCLFPVE CCCCCCCCCEEEECC | 19.64 | 23712012 | |
| 245 | Phosphorylation | LSRVDSTTCLFPVEE CCCCCCCCEEEECCH | 15.91 | 27097102 | |
| 257 | Phosphorylation | VEEKAVEYYFASDAS CCHHHHHEEECCCHH | 9.40 | 21373199 | |
| 478 | Phosphorylation | GVASTKAYTSQFVSL CCCCCHHHHHHHHHH | 14.42 | 26022182 | |
| 479 | Phosphorylation | VASTKAYTSQFVSLV CCCCHHHHHHHHHHH | 22.40 | 26022182 | |
| 480 | Phosphorylation | ASTKAYTSQFVSLVM CCCHHHHHHHHHHHH | 14.67 | 26022182 | |
| 484 | Phosphorylation | AYTSQFVSLVMFALM HHHHHHHHHHHHHHH | 19.28 | 26022182 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GFPT1_RAT !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GFPT1_RAT !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GFPT1_RAT !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of GFPT1_RAT !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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