GFAP_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GFAP_RAT
• UniProt AC: P47819
• Protein Name: Glial fibrillary acidic protein
• Gene Name: Gfap
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 430
• Subcellular Localization: Cytoplasm. Associated with intermediate filaments..
• Protein Description: GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells..
• Protein Sequence: MERRRITSARRSYASSETMVRGHGPTRHLGTIPRLSLSRMTPPLPARVDFSLAGALNAGFKETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLADVYQAELRELRLRLDQLTTNSARLEVERDNLTQDLGTLRQKLQDETNLRLEAENNLAVYRQEADEATLARVDLERKVESLEEEIQFLRKIHEEEVRELQEQLAQQQVHVEMDVAKPDLTAALREIRTQYEAVATSNMQETEEWYRSKFADLTDVASRNAELLRQAKHEANDYRRQLQALTCDLESLRGTNESLERQMREQEERHARESASYQEALARLEEEGQSLKEEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENRITIPVQTFSNLQIRETSLDTKSVSEGHLKRNIVVKTVEMRDGEVIKESKQEHKDVM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MERRRITSARRSYA -CCCHHHHHHHHHHH	17.96	-
11	Methylation	RRITSARRSYASSET HHHHHHHHHHHCCCC	33.46	-
12	Phosphorylation	RITSARRSYASSETM HHHHHHHHHHCCCCC	21.35	27097102
13	Phosphorylation	ITSARRSYASSETMV HHHHHHHHHCCCCCC	14.53	25403869
21	Methylation	ASSETMVRGHGPTRH HCCCCCCCCCCCCCC	22.14	-
34	Citrullination	RHLGTIPRLSLSRMT CCCCCCCCCCCCCCC	32.81	-
34	Citrullination	RHLGTIPRLSLSRMT CCCCCCCCCCCCCCC	32.81	-
36	Phosphorylation	LGTIPRLSLSRMTPP CCCCCCCCCCCCCCC	26.11	22673903
38	Phosphorylation	TIPRLSLSRMTPPLP CCCCCCCCCCCCCCC	19.34	22673903
41	Phosphorylation	RLSLSRMTPPLPARV CCCCCCCCCCCCCEE	22.20	25403869
80	Phosphorylation	ELNDRFASYIEKVRF HHHHHHHHHHHHHHH	24.75	22673903
84	Acetylation	RFASYIEKVRFLEQQ HHHHHHHHHHHHHHH	29.20	3325223
84	Ubiquitination	RFASYIEKVRFLEQQ HHHHHHHHHHHHHHH	29.20	-
93	Ubiquitination	RFLEQQNKALAAELN HHHHHHHHHHHHHHH	40.20	-
93	Acetylation	RFLEQQNKALAAELN HHHHHHHHHHHHHHH	40.20	22902405
108	Phosphorylation	QLRAKEPTKLADVYQ HHHCCCCCCHHHHHH	39.52	-
109	Ubiquitination	LRAKEPTKLADVYQA HHCCCCCCHHHHHHH	53.01	-
109	Acetylation	LRAKEPTKLADVYQA HHCCCCCCHHHHHHH	53.01	22902405
143	Phosphorylation	EVERDNLTQDLGTLR HHHHHHHHCHHHHHH	26.71	-
148	Phosphorylation	NLTQDLGTLRQKLQD HHHCHHHHHHHHHHH	26.51	27097102
152	Acetylation	DLGTLRQKLQDETNL HHHHHHHHHHHHHHC	41.50	22902405
187	Acetylation	ARVDLERKVESLEEE HHHHHHHHHHHHHHH	40.76	22902405
200	Ubiquitination	EEIQFLRKIHEEEVR HHHHHHHHHCHHHHH	51.03	-
258	Ubiquitination	TEEWYRSKFADLTDV HHHHHHHHHHCHHHH	35.26	-
258	Acetylation	TEEWYRSKFADLTDV HHHHHHHHHHCHHHH	35.26	25786129
263	Phosphorylation	RSKFADLTDVASRNA HHHHHCHHHHHHHHH	29.04	22673903
267	Phosphorylation	ADLTDVASRNAELLR HCHHHHHHHHHHHHH	26.39	22673903
268	Citrullination	DLTDVASRNAELLRQ CHHHHHHHHHHHHHH	36.32	-
268	Citrullination	DLTDVASRNAELLRQ CHHHHHHHHHHHHHH	36.32	-
291	Phosphorylation	RRQLQALTCDLESLR HHHHHHHHCCHHHHC	13.64	-
300	Phosphorylation	DLESLRGTNESLERQ CHHHHCCCCHHHHHH	29.40	28432305
303	Phosphorylation	SLRGTNESLERQMRE HHCCCCHHHHHHHHH	37.29	25403869
321	Phosphorylation	RHARESASYQEALAR HHHHHHHHHHHHHHH	36.31	25403869
322	Phosphorylation	HARESASYQEALARL HHHHHHHHHHHHHHH	15.30	25403869
337	Acetylation	EEEGQSLKEEMARHL HHHHHHHHHHHHHHH	57.80	22902405
337	Ubiquitination	EEEGQSLKEEMARHL HHHHHHHHHHHHHHH	57.80	-
366	Acetylation	IEIATYRKLLEGEEN HHHHHHHHHHCCCCC	47.19	22902405
366	Ubiquitination	IEIATYRKLLEGEEN HHHHHHHHHHCCCCC	47.19	-
381	Phosphorylation	RITIPVQTFSNLQIR CEEEEEEEECCCEEE	29.30	25403869
383	Phosphorylation	TIPVQTFSNLQIRET EEEEEEECCCEEEEC	39.76	25403869
395	Ubiquitination	RETSLDTKSVSEGHL EECCCCCCCCCCCCC	48.83	-
403	Ubiquitination	SVSEGHLKRNIVVKT CCCCCCCCCCEEEEE	37.41	-
404	Citrullination	VSEGHLKRNIVVKTV CCCCCCCCCEEEEEE	44.46	-
404	Citrullination	VSEGHLKRNIVVKTV CCCCCCCCCEEEEEE	44.46	-
409	Acetylation	LKRNIVVKTVEMRDG CCCCEEEEEEECCCC	35.64	22902405
414	Citrullination	VVKTVEMRDGEVIKE EEEEEECCCCCCHHH	34.96	-
414	Citrullination	VVKTVEMRDGEVIKE EEEEEECCCCCCHHH	34.96	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
7	T	Phosphorylation	Kinase	AURKB	O55099	Uniprot
7	T	Phosphorylation	Kinase	ROCK1	Q63644	Uniprot
36	S	Phosphorylation	Kinase	AURKB	O55099	Uniprot
36	S	Phosphorylation	Kinase	ROCK1	Q63644	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GFAP_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GFAP_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of GFAP_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.