GELS_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GELS_RAT
• UniProt AC: Q68FP1
• Protein Name: Gelsolin
• Gene Name: Gsn
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 780
• Subcellular Localization: Isoform 1: Secreted.; Isoform 2: Cytoplasm, cytoskeleton. A cytoplasmic form may also exist..
• Protein Description: Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis (By similarity)..
• Protein Sequence: MAPYCSSLRSALLVLALCALSPSHAATASRGRAQERAPQSRVSETRPSTMVVEHPEFLKAGKEPGLQIWRVEKFDLVPVPPNLYGDFFTGDAYVILKTVQLRNGNLQYDLHYWLGNECSQDESGAAAIFTVQLDDYLNGRAVQHREVQGFESSTFQGYFKSGLKYKKGGVASGFKHVVPNEVVVQRLFQVKGRRVVRATEVPVSWDSFNNGDCFILDLGNNIYQWCGSGSNKFERLKATQVSKGIRDNERSGRAQVHVSEEGSEPEAMLQVLGPKPDLPQGTEDTAKEDAANRRLAKLYKVSNSGGSMSVSLVADENPFAQSALRSEDCFILDHGRDGKIFVWKGKQANMDERKAALKTASDFISKMQYPRQTQVSVLPEGGETPLFKQFFKNWRDPDQTDGPGLSYLSSHIANVERVPFDAATLHTSTAMAAQHGMDDDGTGQKQIWRIEGSNKVLVDPATYGQFYGGDSYIILYNYRHGGRQGQIIYNWQGAQSTQDEVAASAILTAQLDEELGGTPVQSRVVQGKEPAHLMSLFGGKPMIIYKGGTSRDGGQTTPASTRLFQVRASSSGATRAVEVMPKAGALNSNDAFVLKTPSAAYLWVGTGASDAEKTGALELLKVLRAQHVQVEEGSEPDGFWEALGGKTAYRTSPRLKDKKMDAHPPRLFACSNRIGRFVIEEVPGELMQEDLATDDVMLLDTWDQVFVWVGKDSQEEEKTEALTSAKRYIETDPANRDRRTPITVVRQGFEPPSFVGWFLGWDDDYWSVDPLDRALAELAA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
84	Phosphorylation	VPVPPNLYGDFFTGD ECCCCCCCCCCCCCC	22.68	-
175	Ubiquitination	GGVASGFKHVVPNEV CCCCCCCCCCCCCHH	38.73	-
175	Acetylation	GGVASGFKHVVPNEV CCCCCCCCCCCCCHH	38.73	22902405
243	Ubiquitination	LKATQVSKGIRDNER HHHHEECCCCCCCCC	60.54	-
297	Acetylation	AANRRLAKLYKVSNS HHHHHHHHHEEECCC	57.87	22902405
339	Acetylation	LDHGRDGKIFVWKGK EECCCCCEEEEEECC	36.94	22902405
358	Acetylation	DERKAALKTASDFIS HHHHHHHHHHHHHHH	37.00	22902405
366	Ubiquitination	TASDFISKMQYPRQT HHHHHHHHCCCCCCC	25.80	-
366	Acetylation	TASDFISKMQYPRQT HHHHHHHHCCCCCCC	25.80	22902405
388	Acetylation	GGETPLFKQFFKNWR CCCCHHHHHHHHCCC	54.61	22902405
392	Acetylation	PLFKQFFKNWRDPDQ HHHHHHHHCCCCCCC	57.81	22902405
407	Phosphorylation	TDGPGLSYLSSHIAN CCCCCHHHHHHHEEC	18.69	-
463	Phosphorylation	VLVDPATYGQFYGGD EEEEHHHEEEECCCC	15.84	-
546	Acetylation	GKPMIIYKGGTSRDG CCCEEEEECCCCCCC	40.22	22902405
556	Phosphorylation	TSRDGGQTTPASTRL CCCCCCCCCCCEEEE	37.71	25403869
557	Phosphorylation	SRDGGQTTPASTRLF CCCCCCCCCCEEEEE	14.68	22108457
560	Phosphorylation	GGQTTPASTRLFQVR CCCCCCCEEEEEEEE	18.44	25403869
582	Acetylation	RAVEVMPKAGALNSN EEEEECCCCCCCCCC	41.16	22902405
596	Phosphorylation	NDAFVLKTPSAAYLW CCEEEEECCCCEEEE	20.51	23984901
598	Phosphorylation	AFVLKTPSAAYLWVG EEEEECCCCEEEEEE	30.66	23984901
601	Phosphorylation	LKTPSAAYLWVGTGA EECCCCEEEEEECCC	10.79	-
621	Acetylation	TGALELLKVLRAQHV HCHHHHHHHHHHCCE	52.42	22902405
634	Phosphorylation	HVQVEEGSEPDGFWE CEEEECCCCCCCHHH	49.59	23984901
649	Phosphorylation	ALGGKTAYRTSPRLK HCCCCCEECCCCCCC	21.47	-
651	Phosphorylation	GGKTAYRTSPRLKDK CCCCEECCCCCCCCC	30.33	25403869
726	Ubiquitination	TEALTSAKRYIETDP HHHHHHHHHHHHCCC	45.56	-
740	Phosphorylation	PANRDRRTPITVVRQ CCCCCCCCCEEEEEC	21.67	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GELS_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GELS_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GELS_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of GELS_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.