GDIR2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GDIR2_MOUSE
• UniProt AC: Q61599
• Protein Name: Rho GDP-dissociation inhibitor 2
• Gene Name: Arhgdib
• Organism: Mus musculus (Mouse).
• Sequence Length: 200
• Subcellular Localization: Cytoplasm, cytosol .
• Protein Description: Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Regulates reorganization of the actin cytoskeleton mediated by Rho family members..
• Protein Sequence: MTEKDAQPQLEEADDDLDSKLNYKPPPQKSLKELQEMDKDDESLTKYKKTLLGDVPVVADPTVPNVTVTRLSLVCDSAPGPITMDLTGDLEALKKDTFVLKEGIEYRVKINFKVNKDIVSGLKYVQHTYRTGMRVDKATFMVGSYGPRPEEYEFLTPVEEAPKGMLARGTYHNKSFFTDDDKQDHLTWEWNLAIKKDWTE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MTEKDAQPQ ------CCHHHCCHH	52.31	-
19	Phosphorylation	EADDDLDSKLNYKPP HCCCCCHHHCCCCCC	46.47	29514104
20	Acetylation	ADDDLDSKLNYKPPP CCCCCHHHCCCCCCC	40.18	-
23	Phosphorylation	DLDSKLNYKPPPQKS CCHHHCCCCCCCCHH	35.00	25159016
24	Acetylation	LDSKLNYKPPPQKSL CHHHCCCCCCCCHHH	50.39	-
30	Phosphorylation	YKPPPQKSLKELQEM CCCCCCHHHHHHHHC	39.15	27600695
32	Ubiquitination	PPPQKSLKELQEMDK CCCCHHHHHHHHCCC	64.57	22790023
39	Ubiquitination	KELQEMDKDDESLTK HHHHHCCCCCHHHHH	66.81	-
39	Acetylation	KELQEMDKDDESLTK HHHHHCCCCCHHHHH	66.81	-
43	Phosphorylation	EMDKDDESLTKYKKT HCCCCCHHHHHHHHH	48.62	26745281
45	Phosphorylation	DKDDESLTKYKKTLL CCCCHHHHHHHHHHH	41.42	26745281
46	Acetylation	KDDESLTKYKKTLLG CCCHHHHHHHHHHHC	61.44	-
75	Glutathionylation	VTRLSLVCDSAPGPI EEEEEEEECCCCCCE	4.08	24333276
97	Phosphorylation	LEALKKDTFVLKEGI HHHHHHCEEEEECCE	25.23	23140645
101	Acetylation	KKDTFVLKEGIEYRV HHCEEEEECCEEEEE	48.90	-
123	Acetylation	KDIVSGLKYVQHTYR HHHHHCCCEEEEHHC	47.07	22826441
128	Phosphorylation	GLKYVQHTYRTGMRV CCCEEEEHHCCCCCC	9.52	25367039
129	Phosphorylation	LKYVQHTYRTGMRVD CCEEEEHHCCCCCCC	12.21	25367039
137	Ubiquitination	RTGMRVDKATFMVGS CCCCCCCEEEEEEEC	46.60	22790023
139	Phosphorylation	GMRVDKATFMVGSYG CCCCCEEEEEEECCC	20.29	26745281
144	Phosphorylation	KATFMVGSYGPRPEE EEEEEEECCCCCHHH	18.59	25266776
145	Phosphorylation	ATFMVGSYGPRPEEY EEEEEECCCCCHHHC	25.81	26745281
152	Phosphorylation	YGPRPEEYEFLTPVE CCCCHHHCEEEEEHH	15.43	26745281
156	Phosphorylation	PEEYEFLTPVEEAPK HHHCEEEEEHHHCCC	30.52	27600695
174	Acetylation	ARGTYHNKSFFTDDD CCCCCCCCCCCCCCC	35.01	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GDIR2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GDIR2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GDIR2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of GDIR2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.