GDIA_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GDIA_RAT
• UniProt AC: P50398
• Protein Name: Rab GDP dissociation inhibitor alpha
• Gene Name: Gdi1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 447
• Subcellular Localization: Cytoplasm. Golgi apparatus, trans-Golgi network.
• Protein Description: Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes..
• Protein Sequence: MDEEYDVIVLGTGLTECILSGIMSVNGKKVLHMDRNPYYGGESSSITPLEELYKRFQLLEGPPESMGRGRDWNVDLIPKFLMANGQLVKMLLYTEVTRYLDFKVVEGSFVYKGGKIYKVPSTETEALASNLMGMFEKRRFRKFLVFVANFDENDPKTFEGVDPQTTSMRDVYRKFDLGQDVIDFTGHALALYRTDDYLDQPCLETINRIKLYSESLARYGKSPYLYPLYGLGELPQGFARLSAIYGGTYMLNKPVDDIIMENGKVVGVKSEGEVARCKQLICDPSYIPDRVRKAGQVIRIICILSHPIKNTNDANSCQIIIPQNQVNRKSDIYVCMISYAHNVAAQGKYIAIASTTVETAEPEKEVEPALELLEPIDQKFVAISDLYEPIDDGSESQVFCSCSYDATTHFETTCNDIKDIYKRMAGSAFDFENMKRKQNDVFGEADQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDEEYDVI -------CCCCCEEE	15.33	-
54	Ubiquitination	TPLEELYKRFQLLEG CCHHHHHHHHHHHHC	60.40	-
54	Acetylation	TPLEELYKRFQLLEG CCHHHHHHHHHHHHC	60.40	22902405
93	Phosphorylation	QLVKMLLYTEVTRYL CEEEHHHHHHHHHHC	9.26	-
112	Acetylation	VEGSFVYKGGKIYKV EEEEEEEECCEEEEC	56.75	22902405
157	Phosphorylation	FDENDPKTFEGVDPQ CCCCCCCCCCCCCCC	32.10	27115346
174	Acetylation	SMRDVYRKFDLGQDV CHHHHHHHCCCCCCE	26.08	22902405
208	Dimethylation	PCLETINRIKLYSES HHHHHHHHHHHHHHH	24.46	-
208	Methylation	PCLETINRIKLYSES HHHHHHHHHHHHHHH	24.46	-
210	"N6,N6-dimethyllysine"	LETINRIKLYSESLA HHHHHHHHHHHHHHH	37.83	-
210	Methylation	LETINRIKLYSESLA HHHHHHHHHHHHHHH	37.83	12692561
213	Phosphorylation	INRIKLYSESLARYG HHHHHHHHHHHHHHC	31.01	20051515
221	Ubiquitination	ESLARYGKSPYLYPL HHHHHHCCCCCEECC	39.05	-
221	Acetylation	ESLARYGKSPYLYPL HHHHHHCCCCCEECC	39.05	22902405
224	Phosphorylation	ARYGKSPYLYPLYGL HHHCCCCCEECCCCC	26.42	-
226	Phosphorylation	YGKSPYLYPLYGLGE HCCCCCEECCCCCCC	5.83	-
229	Phosphorylation	SPYLYPLYGLGELPQ CCCEECCCCCCCCCC	13.05	-
253	Acetylation	GGTYMLNKPVDDIIM CCCEECCCCHHEEEE	42.32	22902405
264	Methylation	DIIMENGKVVGVKSE EEEEECCEEEEECCC	45.38	12692561
269	Acetylation	NGKVVGVKSEGEVAR CCEEEEECCCCCHHH	36.54	22902405
269	Methylation	NGKVVGVKSEGEVAR CCEEEEECCCCCHHH	36.54	12692561
317	S-nitrosylation	NTNDANSCQIIIPQN CCCCCCCCEEEEEHH	3.19	22178444
317	S-nitrosocysteine	NTNDANSCQIIIPQN CCCCCCCCEEEEEHH	3.19	-
339	Phosphorylation	IYVCMISYAHNVAAQ EEEEEEECCCHHHHC	10.85	-
427	Phosphorylation	IYKRMAGSAFDFENM HHHHHCCCCCCHHHH	19.07	28432305
435	Acetylation	AFDFENMKRKQNDVF CCCHHHHHHHHCCCC	68.94	22902405
435	Ubiquitination	AFDFENMKRKQNDVF CCCHHHHHHHHCCCC	68.94	-
437	Ubiquitination	DFENMKRKQNDVFGE CHHHHHHHHCCCCCC	48.19	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
213	S	Phosphorylation	Kinase	SGK1	O00141	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GDIA_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GDIA_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of GDIA_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.